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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2005 / Cilt: 39 - Sayı: 3

A vulvocrural localized Hailey-Hailey case responsive to methotrexate treatment

Metotreksat tedavisine yanıt veren vulvokrual yerleşimli bir hailey-hailey olgusu

Nermin KARAHAN
Vahide BAYSAL
Yüksel Pınar BAŞAK
Öztürk Hümeyra TENEKECİ
Pages
208–210
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No recurrence was observed within four months after cessation of treatment.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hailey-Hailey disease is an autosomai dominant inherited dermatosis characterized by vesicular and crusted lesions in the intertriginous regions.
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Key Findings & Data:The treatment alternatives include classical treatment choices like oral and topical corticosteroides, antibiotics, dapsone, cryosurgery, surgical excision and new treatment alternatives like botulinum toxin, dermabrasion with carbon dioxide laser, photodynamic therapy, topical tacrolimus, topical tacal-citol and methotrexate.
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Conclusion & Impact:No recurrence was observed within four months after cessation of treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hailey-Hailey disease is an autosomai dominant inherited dermatosis characterized by vesicular and crusted lesions in the intertriginous regions. The treatment alternatives include classical treatment choices like oral and topical corticosteroides, antibiotics, dapsone, cryosurgery, surgical excision and new treatment alternatives like botulinum toxin, dermabrasion with carbon dioxide laser, photodynamic therapy, topical tacrolimus, topical tacal-citol and methotrexate. This Hailey-Hailey case is presented because of improvement with methotrexate therapy applied for five months. No recurrence was observed within four months after cessation of treatment.

Özet

Hailey-Hailey hastalığı, intertrijinöz bölgelerde yerleşen veziküller veya krutlanmış erode lezyonlarla karakterize, kronik seyidi, otozomal dominant geçişli bir dermatozdur. Tedavi seçenekleri arasında klasik tedavi yöntemleri olan oral ve topikal kortikosteroidler, antibiyotikler, dapson, kriyoterapi, cerrahi eksizyon ve yeni tedavi alternatifleri olarak da botulinum toksini, karbondioksit lazerle dermabrazyon, fotodinamik tedavi, topikal takrolimus, topikal takalsitol ve metotreksat kullanımı bulunmaktadır. Hailey-Hailey tanısı almış olgu, beş ay süreyle uygulanan metot-reksat tedavisine iyi yanıt vermesi ve dört aylık takibinde rekürrens izlenmemesi nedeniyle sunulmuştur.

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Cite This Article

KARAHAN, N., BAYSAL, V., BAŞAK, Y. P., TENEKECİ, Ö. H. (2022). A vulvocrural localized Hailey-Hailey case responsive to methotrexate treatment. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 39 - Sayı: 3, 208–210. https://ajindex.com/articles/622205

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References (14)

  1. Burge SM: Hailey-Hailey disease: the clinical features, response to treatment and prognosis. Br J Dermatol 1992;126:275-82
  2. Palmer DD, Perry HO: Benign familial chronic pemphigus. Arch Dermatol 1962;86:153-62
  3. Michel B: Commentary: Hailey-Hailey disease. Arch Dermatol 1982;118:781-3
  4. Krishnan RS, Ledbetter LS, Reed JA, Hsu S: Acantholytic dermatosis of the vulvocrural area. Cutis 2001;67:217-20
  5. Galimberti RL, Kowalczuk AM, Bianchi O, Bonino MV, Garcia AG: Chronic benign familial pemphigus. Int J Dermatol 1988;27:495-500
  6. Ikeda S, Ogawa H: Effects of steroid, retinoid, and protease inhibitors on the formation of acantholysis induced in organ culture of skins from patients with benign familial chronic pemphigus. J Invest Dermatol 1991;97:644-8
  7. Lapiere JH, Hirsh A, Gordon KB, Cook B, Montalvo A: Botilinum toxin type A for the treatment of axillary Hailey-Hailey disease. Dermatol Surg 2000;26:371-4
  8. Don PC, Carney PS, Lynch WS, Zaim MT, Hassan MO: Carbon dioxide laser abrasion: a new approach to management of familial benign chronic pemphigus. J Dermatol Surg Oncol 1987;13:1187-94
  9. Fairris GM, White JE, Leppard BJ, Goodwin PG: Methotrexate for intractable benign familial chronic pemphigus. Br J Dermatol 1986;115:640
  10. Roos DE, Reid CM: Benign familial pemphigus: little benefit from superficial radiotherapy. Australas J Dermatol. 2002 Nov;43(4):305-8
  11. Ruiz-Rodriguez R, Alvarez JG, Jaen P, Acevedo A, Cordoba S: Photodynamic therapy with 5-aminolevulinic acid for recalcitrant familial benign pemphigus (Hailey-Hailey disease). J Am Acad Dermatol. 2002 Nov;47(5):740-2
  12. Wieselthier JS, Pincus SH: Hailey-Hailey disease of the vulva. Arch Dermatol 1993;129:1344-5
  13. Sand C, Thomsen HK. Topical tacrolimus ointment is an effective therapy for Hailey-Hailey disease. Arch Dermatol. 2003 Nov; 139(11):1401-2
  14. Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S. 1 alpha, 24 dihydroxyvitamin D3 (tacalitrol) is effective against Hailey-Hailey disease both in vivo and in vitro. Br J Dermatol. 1998 Nov; 139(5): 897-901.