SavedAdd your journal

Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2006 / Cilt: 40 - Sayı: 4

G-CSF-induced atypical pyoderma gangrenosum in a patient with acute myeloid leukemia

Akut miyeloid lösemili bir olguda G-CSF’e bağlı atipik piyoderma gangrenozum

Işıl KÜÇÜKYILMAZ
Özlem YEREBAKAN
Ayşe AKMAN
M. Akif ÇİFTÇİOĞLU
Pages
139–141
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present a case with AML to emphasize that G-CSF administration may lead to atypical bullous pyoderma gangrenosum (PG) by stimulatory effect of AML.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is produced in humans by a variety of cells including fibroblasts, endothelial cells, macrophages, acute myeloid leukemia (AML) cells or recombinant DNA techniques.
📊
Key Findings & Data:Since it stimulates the proliferation of neutrophils, G-CSF has been used for the amelioration of chemotheraphy-induced neutropenia or other neutrophenic conditions.
💡
Conclusion & Impact:We present a case with AML to emphasize that G-CSF administration may lead to atypical bullous pyoderma gangrenosum (PG) by stimulatory effect of AML.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is produced in humans by a variety of cells including fibroblasts, endothelial cells, macrophages, acute myeloid leukemia (AML) cells or recombinant DNA techniques. Since it stimulates the proliferation of neutrophils, G-CSF has been used for the amelioration of chemotheraphy-induced neutropenia or other neutrophenic conditions. Several cutaneous reactions have been reported due to the use of G-CSF. We present a case with AML to emphasize that G-CSF administration may lead to atypical bullous pyoderma gangrenosum (PG) by stimulatory effect of AML.

Özet

Granülosit koloni uyarıcı faktör (G-CSF), insanlarda fibroblastlar, endotel hücreleri, makrofajlar, akut myeloid lösemi (AML) hücreleri gibi çeşitli hücreler tarafından veya rekombinant DNA teknikleri ile üretilen bir hematopoetik büyüme faktörüdür. Nötrofil yapımını uyardığı için, kemoterapiye bağlı nötropeniyi veya diğer nötropenik durumları iyileştirmek için kullanılmaktadır. G-CSF kullanımına bağlı farklı deri reaksiyonları bildirilmiştir. Burada AML'li olgu, G-CSF kullanımının AML'nin uyarıcı etkisiyle atipik piyoderma gangrenozum (PG) geliştirebileceğine dikkat çekmek için sunulmuştur.

🔖

Cite This Article

KÜÇÜKYILMAZ, I., YEREBAKAN, Ö., AKMAN, A., ÇİFTÇİOĞLU, M. A. (2022). G-CSF-induced atypical pyoderma gangrenosum in a patient with acute myeloid leukemia. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 40 - Sayı: 4, 139–141. https://ajindex.com/articles/622172

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (9)

  1. Oppenheim JJ, Ruscetti FW, Faltynek C: Cytokins. Basic and Clinical Immunology. Ed. Stites DP, Terr Al. East Norwalk, Appleton & Lange 1991; 78-100
  2. Shirafuji N, Asano S, Kozai K, Takahashi S, Matsuda S, Takaku F, Na-gata S: Production of granulocyte colony-stimulating factor by acute myelomonocytic leukemia cells. Leuk Res 1988; 12: 745-50
  3. Glass LF, Fotopoulos T, Messina JL: A generalized cutaneous reaction induced by granulocte colony-stimulating factor. J Am Acad Dermatol 1996; 43: 455-9
  4. Johnson ML, Grimwood RE: Leukocyte colony-stimulating factors. A review of associated neutrophilic dermatoses and vasculitides. Arch Dermatol 1994; 130: 77-81
  5. Komamura H, Higashiyama M, Hashimoto K, Takeda K, Kimura H, Tani Y, Ogawa H, Yoshikawa K: Three cases of chemotherapy-induced acral erythema. J Dermatol 1995; 22: 116-21
  6. Su WP, Davis MD, Weenig RH, Powell FC, Perry HO: Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria. Int J Dermatol 2004; 43: 790-800
  7. Powell FC, Su WP, Perry HO: Pyoderma gangrenosum: classification and management. J Am Acad Dermatol 1996; 34: 395-409
  8. Bennett ML, Jackson JM, Jorizzo JL, Fleischer AB Jr, White WL, Callen JP: Pyoderma gangrenosum. A comparison of typical and atypical forms with an emphasis on time to remission. Case review of 86 patients from 2 institutions. Medicine 2000; 79: 37-46
  9. Klaus Wolff, Georg Stingl: Pyoderma gangrenosum. Fitzpatrick's Dermatology in General Medicine. Ed. Freedberg İM, Eisen AZ, Wolf K, Austen KF, Goldssmith LA, Kaltz SI, Fitzpatrick TB. 5'inci baskı. New York, Mc Graw-Hill 1999; 1140-8.