Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2006 / Cilt: 40 - Sayı: 3

Hand-foot syndrome due to capecitabine therapy: Case report

Kapesitabin tedavisi alan hastada gelişen el-ayak sendromu

Pages
105–107
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We report an 68 year old woman with breast carcinoma who developed diffuse erythematous and edematous plaques on her hands and feet due to capecitabine therapy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hand-foot syndrome, also known as palmar-plantar dysestesia is a drug reaction which is characterized by dysestesia, erythema, and edema desquamation in palms of hands and soles of the feet.
📊
Key Findings & Data:Cytarabine, doxorubicine, capecitabine, epirubicin, fluorodeoxyuridine, hydroxyurea, mercaptopurine, cyclophosphamide, docetaxel, vinorelbine and 5-FU are the drugs related with hand-foot syndrome.
💡
Conclusion & Impact:We report an 68 year old woman with breast carcinoma who developed diffuse erythematous and edematous plaques on her hands and feet due to capecitabine therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Hand-foot syndrome, also known as palmar-plantar dysestesia is a drug reaction which is characterized by dysestesia, erythema, and edema desquamation in palms of hands and soles of the feet. Cytarabine, doxorubicine, capecitabine, epirubicin, fluorodeoxyuridine, hydroxyurea, mercaptopurine, cyclophosphamide, docetaxel, vinorelbine and 5-FU are the drugs related with hand-foot syndrome. We report an 68 year old woman with breast carcinoma who developed diffuse erythematous and edematous plaques on her hands and feet due to capecitabine therapy.

Özet

Palmar plantar eritrodizestezi sendromu olarak da bilinen el-ayak sendromu, çeşitli kemoterapi ilaçlarının kullanımı sırasında oluşan bir ilaç reaksiyonudur. Palmar ve plantar bölgelerde çeşitli derecelerde dizestezi, eritem ve ödemle beraber deskuamasyon izlenir. El-ayak sendromuyla ilişkili ilaçlar; sitarabin, doksorubisin, kapesitabin, epirubisin, florodeoksiüridin, hidroksiüre, merkaptopürin, siklofosfamid, dosetaksel, vinorelbin ve 5-FU'i içermektedir. Bu yazıda meme karsinomu nedeniyle kapesitabin tedavisi almaktayken palmar ve plantar bölgelerde diffüz eritemli ve ödemli plaklar gelişen 68 yaşında kadın hasta bildirilmektedir.

🔖

Cite This Article

ŞENDUR, N., KARAMAN, G., ŞAVK, E., MEYDAN, N., USLU, M., USLU, G. (2022). Hand-foot syndrome due to capecitabine therapy: Case report. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 40 - Sayı: 3, 105–107. https://ajindex.com/articles/622162

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Elasmar SA, Saad ED, Hoff PM: Case report: hand-foot syndrome induced by the oral fluoropyrimidine S-1. Jpn J Clin Oncol 2001; 31: 172-174
  2. Budman DR: Capecitabine. Invest New Drugs 2000; 18: 355-363
  3. Chen GY, Chen YH, Hsu MML, Tsao CJ, Chen WC: Onychomadesis and onicholysis associated with capecitabine. Br J Dermatol 2001; 145: 521-523
  4. Gerbrect BM: Current Canadian experience with capecitabine: partnering with patients to optimize therapy. Cancer Nurs 2003; 26: 161-167 (Abstract)
  5. Liu X, Song S, Guan Z, Wu S: Capecitabine (xeloda) in the treatment of relapsed and metastatic breast cancer. Zhonghua Zhong Liu Za Zhi 2002; 24: 71-73 (Abstract)
  6. Nishida M: Pharmalogical and clinical properties of xeloda (capecitabine), a new oral active derivative of fluoropyrmidine. Nippon Yakurigaku Zasshi 2003; 122: 549-553
  7. Smorenburg CH, Bontenbal M, Verweij J: Capecitabine in breast cancer: current status. Clin Breast Cancer 2001; 1: 288-293 (Abstract)
  8. Vivier A: Atlas of Clinical Dermatology
  9. Baskı. Spain, Elsevier Science Limited, 2002: 405-411
  10. Risum S, Langer SW: Plantar-palmar erythrodysesthesia. A new and relatively frequent side effect in antineoplastic treatment. Ugeskr Laeger 2003; 165: 3161-3162 (Abstract)
  11. Lin E, Morris JS, Ayers GD: Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. Oncology 2002; 16:31-37
  12. Abushullaih S, Saad ED, Munsell M: Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single institution experience. Cancer Invest 2002; 20: 3-10
  13. Maino KL, Norwood C, Stashower ME: Onycholysis with the appereance of a "sunset" secondary to capecitabine. Cutis 2003; 72:234-236.