AI Summary & Key Takeaways
AI InsightWe found that the mean value of triglyceride levels was statistically higher in the psoriasis group (p
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Abstract
Background and Design: Psoriasis is one of the chronic inflammatory systemic diseases, such as rheumatoid arthritis, systemic lupus erythematosus and Crohn's disease, in which the inflammation is responsible for the pathogenesis. Recently, some studies reported the importance of chronic inflammation in the pathogenesis of atherosclerosis and an association of chronic inflammatory systemic diseases with atherosclerosis and metabolic syndrome. The aim of this study is to determine coexistence of psoriasis vulgaris with various severity and metabolic syndrome. Material and Method: One hundred psoriasis vulgaris patients and one hundred sex- and age-matched healthy controls were included in this study. The Psoriasis Area and Severity Index (PASI) was used for evaluating the disease severity in psoriasis patients. A PASI score below 7 was accepted as mild, between 7-12 as moderate, and above 12 as severe. We evaluated metabolic syndrome in both patient and control groups by using the Adult Treatment Panel III (ATP III) metabolic syndrome criteria. SPSS 10.0 for Windows was used in analyzing data. For comparison, the student’s-t test, the Mann-Whitney U test and the chi-square test were used. A p-value less than 0.05 was considered statistically significant. Results: Metabolic syndrome, hypertension, elevated fasting plasma glucose and triglyceride levels, high waist circumference and lower high-density lipoprotein levels were more common in patients with psoriasis than in controls. However, there was no statistically significant difference in these parameters between these two groups (p>0.05). We found that the mean value of triglyceride levels was statistically higher in the psoriasis group (p
Özet
Amaç: Psoriasis; romatoid artrit, sistemik lupus eritematozus, Crohn hastalığı gibi patogenezinde inflamasyonun rol oynadığı kronik inflamatuvar sistemik hastalıklar grubunda yer almaktadır. Son zamanlarda kronik inflamasyonun ateroskleroz patogenezinde önemine ve kronik inflamatuvar hastalıklar ile ateroskleroz-metabolik sendrom birlikteliğine değinen çalışmalar bulunmaktadır. Bu çalışmanın amacı değişik şiddetteki psoriasis vulgarisli hastalarda metabolik sendrom birlikteliğini araştırmaktı. Gereç ve Yöntem: Çalışmaya 100 psoriasis vulgarisli hasta, yaş ve cinsiyeti hasta grubuyla uyumlu 100 sağlıklı kontrol alındı. Psoriasisli hastalarda hastalığın şiddetinin değerlendirilmesinde PAŞİ kullanıldı. PAŞİ değeri 7’nin altında olanlar hafif, 7-12 arası orta ve 12’nin üzerinde olanlar şiddetli olarak kabul edildi. Hasta ve kontrol grubunda ATP III metabolik sendrom kriterleri kullanılarak metabolik sendrom araştırıldı. Verilerin değerlendirilmesinde SPSS for windows 10.0 istatistik paket programı kullanıldı. Karşılaştırmalarda student’s t, Mann Whitney U, ki-kare testleri kullanıldı. p0,05). Psoriasis grubunun ortalama trigliserid düzeyi kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek saptandı (p