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Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2013 / Cilt: 47 - Sayı: 4

Investigation of adenosine deaminase activity in patients with mycosis fungoides

Mikozis fungoidesli hastalarda adenozin deaminaz aktivitesinin araştırılması

Ayten FERAHBAŞ
Demet KARTAL
Cevat YAZICI
Yılmaz ULAŞ
Pages
227–231
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Results: Patients with MF had more significantly elevated plasma and tissue ADA activity levels than those of controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Mycosis fungoides (MF) is a cutaneous T cell lymphoma.
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Key Findings & Data:Materials and Methods: The levels of ADA activities in both plasma and tissue were spectrophotometrically measured in 40 patients with MF and compared to those of 33 healthy subjects.
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Conclusion & Impact:Results: Patients with MF had more significantly elevated plasma and tissue ADA activity levels than those of controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Mycosis fungoides (MF) is a cutaneous T cell lymphoma. The clinical and histopathological diagnosis of early mycosis fungoides is usually difficult. There is no special laboratory method for the diagnosis of MF and this is the most important problem in diagnosis and follow up the effectiveness of treatment. Adenosine deaminase (ADA) activity is a non-specific marker of T cell activation. In the present study, we aimed to investigate the levels of plasma and tissue ADA in patients with mycosis fungoides and to determine if ADA is an activation criterion for this disease. Materials and Methods: The levels of ADA activities in both plasma and tissue were spectrophotometrically measured in 40 patients with MF and compared to those of 33 healthy subjects. Moreover, a subgroup analysis regarding ADA activities was performed in 17 patients who achieved complete remission after different kinds of treatments. Results: Patients with MF had more significantly elevated plasma and tissue ADA activity levels than those of controls (p

Özet

Amaç: Mikozis fungoides (MF) derinin T hücreli lenfomasıdır. Primer olarak deride gelişme gösteren malin T hücreler çeşitli klinik bulgulara yol açarlar. Erken dönem mikozis fungoides tanısını koyabilmek klinik ve histopatolojik olarak çoğu zaman zordur. Tanı ve takibinde karşılaşılan orluklardan en önemlisi; aktivitesini belirtecek özel bir laboratuvar yönteminin olmamasıdır. Adenozin deaminaz (ADA) T lenfosit aktivasyonun özgün olmayan bir göstergesi olarak kabul edilir. Bu çalışmada; MFli hastalarda plazma ve doku ADA düzeylerinin ölçülmesi ve ADAnın bu hastalık için bir aktivasyon kriteri olup olmadığının araştırılması amaçlandı. Gereç ve Yöntem: Çalışmada 40 MF ve 33 kontrol olgusunda spektrofotometrik yöntem kullanılarak plazma ve doku ADA aktiviteleri ölçüldü. Ayrıca hasta grubu içerisinden takipler sonucunda remisyon kriterlerini tamamlayan ve remisyon olarak kabul edilen 17 hastanın bu dönemde değerlendirmeleri yapıldı. Bulgular: Plazma ve doku ADA düzeyleri MFli hastalarda kontrol grubuna göre anlamlı derecede yüksek bulundu (sırasıyla, p

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Cite This Article

FERAHBAŞ, A., KARTAL, D., YAZICI, C., ULAŞ, Y. (2022). Investigation of adenosine deaminase activity in patients with mycosis fungoides. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 47 - Sayı: 4, 227–231. https://ajindex.com/articles/621904

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