Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2013 / Cilt: 47 - Sayı: 3

Herpes zoster in cancer patientsafter radiotherapy

Kanserlihastalarda radyoterapi sonrasıherpes zoster

Pages
170–175
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is possible to reduce the risk of morbidity and mortality with early treatment or varicella vaccine. (Turkderm 2013; 47: 170-5)

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Herpes Zoster (HZ) results from reactivation of the varicella-zoster virus.
📊
Key Findings & Data:Materials and Methods: We retrospectively analyzed the data of patients, who had a diagnosis of HZ after radiotherapy between June 2005 and September 2012.
💡
Conclusion & Impact:It is possible to reduce the risk of morbidity and mortality with early treatment or varicella vaccine. (Turkderm 2013; 47: 170-5)
🔬Design:Research Article
📍Scope:2005 Verileri
⚙️Variables:Domain Parameters

Abstract

Background and Design: Herpes Zoster (HZ) results from reactivation of the varicella-zoster virus. It occurs with increasing frequency in the elderly and encountered especially in immünosuppressed patients. The aim of this retrospective study was to analyze the pathogenesis, epidemiological, clinical and therapeutic profiles of HZ after radiotherapy. Materials and Methods: We retrospectively analyzed the data of patients, who had a diagnosis of HZ after radiotherapy between June 2005 and September 2012. Results: A HZ after completion of radiotherapy occurred in 30 of 6784 patients mostly within the first 2-46 months (mean 25). Fifteen patients were men and the mean age of the patients was 58 years. Twelve patients had breast cancer, seven patients had lung cancer and, five patients had prostate cancer. Twenty-six patients were distressed and 4 patients had physical trauma. The most frequent complaints were pain and burning (54.2%). All infections remained localized (60% thoracic) and there was no evidence of systemic infections. Three patients had an eruption involvement in the radiotherapy area. Duration of symptoms ranged from 1 to 7 days. All patients were treated with oral acyclovir. Postherpetic neuralgia developed in nine patients. Conclusion: HZ is more common in immünocompromised cancer patients especially after radiotherapy. It is possible to reduce the risk of morbidity and mortality with early treatment or varicella vaccine. (Turkderm 2013; 47: 170-5)

Özet

Amaç: Herpes zoster (HZ) suçiçeği virüsünün reaktivasyonu ile oluşur. Genellikle erişkin çağda görülür. Hücresel bağışıklığın azalması ile görülme sıklığı artar. Bu çalışmanın amacı, radyoterapi sonrası görülen HZ olgularının etyolojisi, patogenezi, klinik bulguları ve tedavi yaklaşımlarını değerlendirmektir. Gereç ve Yöntem: Haziran 2005 ve Eylül 2012 tarihleri arasında radyoterapi sonrası HZ tanısı konulan hastaların verileri retrospektif olarak incelendi. Bulgular: HZ tanılı 6784 hastanın sadece 30unda radyoterapi sonrası 2-46 ay (ortalama 25) tanı konuldu. Olguların 15i erkek hasta ve yaş ortalaması 58 idi. On iki hasta meme, 7si akciğer, 5i prostat kanseriydi. Olguların 26sında stres, 4ünde travma öyküsü vardı. En sık görülen semptomlar ağrı ve yanma idi. Tüm hastalarda lokalize (%60 torakal) tutulum var iken sistemik tutulum hiçbir hastada görülmedi. Üç hastada radyoterapi alanında döküntü gelişti. Semptom süresi 1-7 gün arasındaydı. Hastaların hepsine oral asiklovir verildi. Dokuz hastada postherpetik nevralji gelişti. Sonuç: HZ, radyoterapi sonrası bağışıklık sistemi zayıflamış olan kanser hastalarında daha çok görülebilen bir hastalıktır. Bu hastalarda tedaviye erken başlanılması veya HZ virüs aşılarının kullanılması ile morbidite ve mortaliteyi azaltmak mümkündür. (Türk­derm 2013; 47: 170-5)

🔖

Cite This Article

TURASAN, A., BENDERLİ, Y. C. (2022). Herpes zoster in cancer patientsafter radiotherapy. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 47 - Sayı: 3, 170–175. https://ajindex.com/articles/621883

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Straus SE, Oxman MN, Schmader KE: Varicella and herpes zoster. Dermatology in general medicine. Ed: Wolff K, Goldsmith LA, Katz SI, et al. Seventh edition. New York, McGraw-Hill Companies, 2008;1885-98. Whitley RJ: Varicella-zoster virus infections. Ed. Kasper LD, Braunwald E, Fauci SA, Hauser LS, Longo LD, Jameson LJ. Harrison’s Principles Internal Medicine.16th ed. United States of America, McGraw-Hill, 2005;1042-5.
  2. Yawn BP, Saddier P, Wollan PC, et al: A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc 2007;82:1341-9.
  3. Yavaşoğlu İ, Arslan E, Gök M, Kurna R: Erişkin zona: olgu serisi ve derleme. Uludağ Üniversitesi Tıp Fakültesi Dergisi 2008;34:123-5.
  4. Donahue JG, Choo PW, Manson JE, Platt R: The incidence of herpes zoster. Arch Intern Med 1995;155:1605-9.
  5. Rusthoven JJ, Ahlgren P, Elhakim T, et al: Varicella-zoster infection in adult cancer patients. A population study. Arch Intern Med 1988;148:1561-6. Arvin AM: Varicella-zoster virus. Clin Microbiol Rev 1996;9:361-81.
  6. Bayram HG, Özcan H, Bayındır Y: Rekürren herpes zoster olgusunda profilaktik antiviral tedavi. Turkderm 2011;45:111-4.
  7. Çölgeçen E, Küçük Ö, Balcı M: Çocukluk çağı herpes zoster infeksiyonun klinik özellikleri. Turkderm 2012;46:26-8.
  8. Hata A, Kuniyoshi M, Ohkusa Y: Risk of Herpes zoster in patients with underlying diseases: a retrospective hospital-based cohort study. Infection 2011;39:537-44.
  9. Ragozzino MW, Melton LJ 3rd, Kurland LT, Chu CP, Perry HO: Risk of cancer after herpes zoster: a population-based study. N Engl J Med 1982;307:393-7.
  10. Guinee VF, Guido JJ, Pfalzgraf KA, et al: The incidence of herpes zoster in patients with Hodgkin's disease. An analysis of prognostic factors. Cancer 1985;56:642-8.
  11. Soyuncu S, Berk Y, Eken C, Gulen B, Oktay C: Herpes zoster as a useful clinical marker of underlying cell-mediated immüne disorders. Ann Acad Med Singapore 2009;38:136-8.
  12. Schimpff S, Serpick A, Stoler B, et al: Varicella-Zoster infection in patients with cancer. Ann Intern Med 1972;76:241-54.
  13. Smith JB, Fenske NA: Herpes zoster and internal malignancy. South Med J 1995;88: 1089-92.
  14. Levin MJ, Hayward AR: The varicella vaccine. Prevention of herpes zoster. Infect Dis Clin North Am 1996;10:657-75.
  15. Hambleton S, Gershon AA: Preventing varicella-zoster disease. Clin Microbiol Rev 2005;18:70-80.
  16. Ahmed AM, Brantley JS, Madkan V, Mendoza N, Tyring SK: Managing herpes zoster in immünocompromised patients. Herpes 2007;14:32-6