Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2014 / Cilt: 48 - Sayı: 1

Effectsofnarrowband UVB, UVA1 and PUVA treatments on dermoscopic features of melanocytic nevi

Darbant UVB, UVA1 ve PUVA tedavilerinin melanositik nevusların dermoskopik bulguları üzerine etkileri

Pages
26–30
Publication Date
2022-11-05
DOI
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Conclusion: Narrowband UVB, UVA1 and PUVA therapies have significant effects on dermoscopic features of melanocytic nevi. (Turk­derm 2014; 48: 26-30)

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Design: Ultraviolet (UV) radiation can affect dermoscopic features of melanocytic nevi by inducing melanin synthesis or melanocyte proliferation.
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Key Findings & Data:The present study was designed to determine the effects of narrowband UVB, UVA1 and psoralen and UVA (PUVA) treatments on dermoscopic features of melanocytic nevi.
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Conclusion & Impact:Conclusion: Narrowband UVB, UVA1 and PUVA therapies have significant effects on dermoscopic features of melanocytic nevi. (Turk­derm 2014; 48: 26-30)
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Background and Design: Ultraviolet (UV) radiation can affect dermoscopic features of melanocytic nevi by inducing melanin synthesis or melanocyte proliferation. Despite widespread use of UV radiation in the treatment of several skin diseases, there have been only a few studies on its effects on the dermoscopic features of melanocytic nevi. The present study was designed to determine the effects of narrowband UVB, UVA1 and psoralen and UVA (PUVA) treatments on dermoscopic features of melanocytic nevi. Material and Method: A total of 55 patients, who were referred to our phototherapy unit for the treatment of various skin disorders, were enrolled in this prospective study. Twenty-one patients underwent narrowband UVB, 18 patients underwent UVA1 and 16 patients underwent PUVA treatment. Dermoscopic images of 233 nevi in narrowband UVB group, 233 nevi in UVA1 group and 229 nevi in PUVA group were evaluated for the alterations in dermoscopic structures at the end of three months. Total dermoscopic scores (TDSs) of melanocytic nevi were calculated according to the ABCD rule. Results: There was no statistically significant inrease in the size of melanocytic nevi in the therapy groups. Narrowband UVB, UVA1, and PUVA resulted in statistically significant changes in the dermoscopic structures of melanocytic nevi. In narrowband UVB therapy group, de novo dot formation was documented (p=0.002). Only in narrowband UVB group, de novo dot formation was observed. There was no statistically significant change in the mean TDS. Conclusion: Narrowband UVB, UVA1 and PUVA therapies have significant effects on dermoscopic features of melanocytic nevi. (Turk­derm 2014; 48: 26-30)

Özet

Amaç: Ultraviyole (UV) ışınları melanin sentezini veya melanosit proliferasyonunu arttırarak melanositik nevuslarda dermoskopik değişikliklere neden olabilmektedir. UV ışınlarının dermatolojide foto(kemo)terapi amacıyla yaygın kullanımına rağmen melanositik nevusların dermoskopik özelliklerine etkileriyle ilgili az sayıda çalışma bulunmaktadır. Bu çalışmada dar bant UVB (dbUVB), UVA1, psoralen ve ultraviyole A (PUVA) tedavilerinin melanositik nevusların dermoskopik bulguları üzerine etkilerini saptamayı amaçladık. Gereç ve Yöntem: Çalışmamıza çeşitli endikasyonlarda fototerapi ünitemizde dar bant UVB tedavisi başlanan 21 hasta, UVA1 tedavisi başlanan 18 hasta ve PUVA tedavisi başlanan 16 hasta olmak üzere toplam 55 hasta dahil edilmiştir. Dar bant UVB grubunda toplam 233, UVA1 grubunda toplam 233 ve PUVA grubunda toplam 229 melanositik nevus, tedavinin 3. ayında dermoskopik değişiklikler yönünden değerlendirilmiştir. Tüm melanositik nevuslar ABCD kuralına göre değerlendirilmiş ve toplam dermoskopi skoru (TDS) hesaplanmıştır. Bulgular: Dar bant UVB, UVA1 ve PUVA tedavilerinin melanositik nevusların büyüklüğünde istatistiksel olarak anlamlı artış saptanmamıştır. Dar bant UVB, UVA1 ve PUVA tedavileri melanositik nevuslarda izlenen dermoskopik yapılarda istatistiksel anlamlı değişikliğe neden olmuştur. Dar bant UVB grubunda melanositik nevuslarda de novo nokta yapısı izlenmiştir. TDSde istatistiksel olarak anlamlı derecede değişiklik saptanmamıştır. Sonuç: dbUVB, UVA1 ve PUVA tedavilerinin melanositik nevusların dermoskopik bulgularında anlamlı derecede değişikliklere neden olmuştur. (Türk­derm 2014; 48: 26-30)

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Cite This Article

KARACA, F., ÖZTAŞ, M., GÜRER, M. A. (2022). Effectsofnarrowband UVB, UVA1 and PUVA treatments on dermoscopic features of melanocytic nevi. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 48 - Sayı: 1, 26–30. https://ajindex.com/articles/621829

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