Journals / Türkderm-Deri Hastalıkları ve Frengi Arşivi / 2018 / Cilt: 52 - Sayı: 1

Antioxidant activity in melasma

Melazmada antioksidan aktivite

Pages
33–36
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Serum trolox equivalent antioxidant capacity (TEAC), total antioxidant activity (TAOA), and ferric reducing power (FRAP) were evaluated in patients and controls by spectrophotometric method.Results: TEAC levels were higher in patients than in controls (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background and Design: Melasma is a common, symmetric hypermelanosis characterized by irregular brown to gray-brown macules on the face.
📊
Key Findings & Data:To investigate serum antioxidant capacity in patients with melasma and relationship between antioxidant levels and melasma severity.Materials and Methods: Forty-nine cases of melasma and 35 controls were included in the study.
💡
Conclusion & Impact:Serum trolox equivalent antioxidant capacity (TEAC), total antioxidant activity (TAOA), and ferric reducing power (FRAP) were evaluated in patients and controls by spectrophotometric method.Results: TEAC levels were higher in patients than in controls (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background and Design: Melasma is a common, symmetric hypermelanosis characterized by irregular brown to gray-brown macules on the face. It is frequently associated with pregnancy and oral contraceptive consumption. Sunlight and genetic factors play major roles in the pathogenesis of melasma. Human skin exposed to ultraviolet light or environmental oxidizing pollutants become a preferred target of oxidative stress. Topical and oral antioxidants are used to treat melasma. To investigate serum antioxidant capacity in patients with melasma and relationship between antioxidant levels and melasma severity.Materials and Methods: Forty-nine cases of melasma and 35 controls were included in the study. Each patient’s skin pigmentation was assessed using the Melasma Area Severity Index (MASI) and mexameter reading. Serum trolox equivalent antioxidant capacity (TEAC), total antioxidant activity (TAOA), and ferric reducing power (FRAP) were evaluated in patients and controls by spectrophotometric method.Results: TEAC levels were higher in patients than in controls (p

Özet

Amaç: Melazma sık görülen, yüzde kahverengiden gri-kahverengiye değişen düzensiz şekilli maküllerle karakterize simetrik bir hipermelanozisdir. Çoğunlukla gebelik periyodu ve oral kontraseptif ilaç kullanımı ile ilişkilidir. Güneş ışığı ve genetik faktörler melazma patogenezinde önemli rol oynamaktadır. Deri ultraviyole ışığı ve çevresel okside edici etmenlere maruz kalarak oksidatif stresin hedefi haline gelmektedir. Topikal ve oral antioksidanlar melazma tedavisinde kullanılmaktadır. Bu araştırmada amaç, melazmalı hastalarda serum antioksidan kapasitesini saptamak ve antioksidan düzeyleri ile melazma şiddeti arasındaki ilişkiyi belirlemektir. Gereç ve Yöntem: Kırk dokuz melazma hastası ve 35 kontrol çalışmaya dahil edildi. Her hastada derideki pigmentasyon düzeyi Melazma Alan Şiddet İndeksi (MAŞİ) ve meksametre skoru kullanılarak değerlendirildi. Serum troloks eşdeğeri antioksidan kapasite (TEAC), total antioksidan aktivite (TAOA), demir iyonu indirgeyici antioksidan güç yöntemi (FRAP) düzeyleri spektrofotometrik olarak hasta ve kontrol grubunda değerlendirildi. Bulgular: TEAC düzeyi hastalarda kontrol grubuna göre daha yüksek idi (p

🔖

Cite This Article

ÜNAL, İ., SÖZMEN, E. Y., AKÇAY, Y., ERTAN, İ., ÖZKAPU, T. (2022). Antioxidant activity in melasma. Türkderm-Deri Hastalıkları ve Frengi Arşivi, Cilt: 52 - Sayı: 1, 33–36. https://ajindex.com/articles/621694

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Hayakawa R, Ueda H, Nozaki T, et al: Effects of combination treatment with vitamin E and C on chloasma and pigmented contact dermatitis. A double blind controlled clinical trial. Acta Vitaminol Enzymol 1981
  2. Alvin G, Catambay N, Vergara A, Jamora MJ: A comparative study of the safety and efficacy of 75% mulberry (Morus alba) extract oil versus placebo as a topical treatment for melasma: a randomized, single-blind, placebo-controlled trial. J Drugs Dermatol 2011
  3. Ni Z, Mu Y, Gulati O: Treatment of melasma with Pycnogenol. Phytother Res 2002
  4. Huh CH, Seo KI, Park JY, Lim JG, Eun HC, Park KC: A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melasma. Dermatology 2003
  5. Astaneh R, Farboud E, Nazemi MJ: 4% hydroquinone versus 4% hydroquinone, 0.05% dexamethasone and 0.05% tretinoin in the treatment of melasma: a comparative study. Int J Dermatol 2005
  6. Pulido R, Bravo L, Saura-Calixto F: Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J Agric Food Chem 2000
  7. Yıldırım HK, Akçay YD, Güvenç U, Altındişli A, Sözmen EY: Antioxidant Activities Of Organic Grape, Pomace, Juice, Must, Wine And Their Correlation With Phenolic Content. Int J Food Sci and Tech 2005
  8. RE R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C: Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999
  9. Hwang SW, Oh DJ, Lee D, Kim JW, Park SW: Clinical efficacy of 25% L-ascorbic acid (C'ensil) in the treatment of melasma. J Cutan Med Surg 2009
  10. Cook-Bolden FE, Hamilton SF: An open-label study of the efficacy and tolerability of microencapsulated hydroquinone 4% and retinol 0.15% with antioxidants for the treatment of hyperpigmentation. Cutis 2008
  11. Lee GS: Intravenous vitamin C in the treatment of post-laser hyperpigmentation for melasma: a short report. J Cosmet Laser Ther 2008
  12. Espinal-Perez LE, Moncada B, Castanedo-Cazares JP: A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. Int J Dermatol 2004
  13. Yamakoshi J, Sano A, Tokutake S,et al: Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 2004
  14. Chang MW: Disorders of hyperpigmentation. In Dermatology, Ed. Bolognia JL, Jorizzo JL, Schaffer JV. S