Journals / Türk Dermatoloji Dergisi / 2018 / Cilt: 12 - Sayı: 1

Psoriasisin Doğal Seyrinin Tanımlanması: 100 Hastadan Oluşan Tek-Merkezli Bir Kohort Çalışması

Defining the Natural Course of Psoriasis: A Single-Center Cohort Study of 100 Patients

Pages
33–37
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Over time, the number of comorbidities accompanying psoriasis increases.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study is to determine chronologically the occurrence of clinical forms and individual lesions of psoriasis patients.Methods: A total of 100 patients (mean age 42.07±16.12 years) were included in this retrospective cohort study.
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Key Findings & Data:The patients were also assessed for accompanying comorbidities during the course of disease.Results: Skin manifestations were the most frequent observed onset area of the disease (95%) and the most common clinical morphology at the onset of the disease was psoriasis vulgaris (92%).
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Conclusion & Impact:Over time, the number of comorbidities accompanying psoriasis increases.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to determine chronologically the occurrence of clinical forms and individual lesions of psoriasis patients.Methods: A total of 100 patients (mean age 42.07±16.12 years) were included in this retrospective cohort study. Individual lesions and changes in clinic forms recorded chronologically. The patients were also assessed for accompanying comorbidities during the course of disease.Results: Skin manifestations were the most frequent observed onset area of the disease (95%) and the most common clinical morphology at the onset of the disease was psoriasis vulgaris (92%). Scalp (19%) was the most frequent onset area of the disease. Clinical morphologic changes were detected in 26 patients during the course of the disease. The most common clinical morphological change was guttate psoriasis (n=17). In survival analysis, average time between the appearance of the first symptom and skin involvement, nail involvement, and articular involvement was calculated as 0.23±0.106, 5.89±1.07 and 2.25±1.10 (mean ± standard error) years, respectively. During the average 11-year disease course, two-fold increase observed in accompanying diseases.Conclusion: Our study shows that psoriasis starts with the skin involvement, nail and joint involvement develop later. Psoriasis vulgaris is the most frequently observed clinical morphology; scalp is the most commonly affected skin area at the onset of the disease. Over time, the number of comorbidities accompanying psoriasis increases.

Özet

Amaç: Bu çalışmanın amacı, psoriasis hastalarının klinik form ve bireysel lezyonlarınınortaya çıkışının kronolojik olarak belirlenmesidir.Yöntemler: Bu retrospektif kohort çalışmasına toplam 100 hasta (ortalama yaş42,07±16,12 yıl) dahil edildi. Bireysel lezyonlar ve klinik formlardaki değişim kronolojikolarak kaydedildi. Hastalar aynı zamanda hastalık süresince eşlik eden ek hastalıklaraçısından da değerlendirildi.Bulgular: Deri belirtileri hastalığın en sık gözlemlenen başlangıç alanıydı (%95) ve hastalığınbaşlangıcında en sık gözlenen klinik morfoloji psoriasis vulgaristi (%92). Hastalığın ensık gözlenen başlangıç yeri saçlı deriydi (%19). Hastalığın seyrinde toplam 26 hastadaklinik morfolojide değişiklikler saptandı. En sık gözlenen klinik morfoloji değişikliği guttatpsoriasisteydi (n=17). Sağkalım analizi sonucunda; başlangıç semptomunu takibenderi belirtilerinin çıkması için geçen ortalama süre 0,23±0,106 yıl, tırnak için 5,89±1,07 yılve eklem için ise 2,25±1,10 yıl idi. Ortalama 11 yıllık hastalık süresi boyunca eşlik edenhastalıklarda iki kat artış gözlendi.Sonuç: Çalışmamız psoriasisin en sık deri tutulumu ile başladığını, tırnak ve eklemtutulumlarının daha sonra geliştiğini göstermektedir. Psoriasis vulgaris en sık gözlenenklinik morfoloji; saçlı deri ise hastalığın başlangıcında en çok etkilenen deri alanıdır.Psoriasiste zamanla eşlik eden ek hastalıkların sayısı artmaktadır.

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Cite This Article

ALPSOY, E., DÖNMEZ, L., NAZLIM, B., KURT, B. Ö., BOZKURT, S., YILMAZ, E., KARAKAŞ, A. A. (2022). Psoriasisin Doğal Seyrinin Tanımlanması: 100 Hastadan Oluşan Tek-Merkezli Bir Kohort Çalışması. Türk Dermatoloji Dergisi, Cilt: 12 - Sayı: 1, 33–37. https://ajindex.com/articles/621560

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