Journals / Türk Beyin Damar Hastalıkları Dergisi / 2000 / Cilt: 6 - Sayı: 3

The relationship between serum magnesium level and atherosclerosis of carotid arteries in ischemic stroke cases

İskemik inmeli olgularda serum magnezyum düzeyi ile karotis aterosklerotik lezyonu arasındaki ilişki

Pages
71–76
Publication Date
2022-11-04
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In order to see the consistency and the nature of the association new studies are needed.

📌 3 Key Takeaways

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Objective & Hypothesis:This study was performed to investigate the relationship between serum magnesium level and atherosclerosis of carotid arteries in ischemic stroke cases.
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Key Findings & Data:Eighty-five patients with ischemic stroke (48 females, 37 males) were included in the study.
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Conclusion & Impact:In order to see the consistency and the nature of the association new studies are needed.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was performed to investigate the relationship between serum magnesium level and atherosclerosis of carotid arteries in ischemic stroke cases. Eighty-five patients with ischemic stroke (48 females, 37 males) were included in the study. In all patients serum magnesium levels were measured and color Doppler ultrasonographic evaluation of bilateral carotid arteries was performed. While 56 cases having progressive intimal hyperplasie and plaque and/or stenosis of carotid arteries formed the case group, 29 patients having minimal intimal hyperplasie the control group. The independent variables other than serum magnesium levels were as follows: Age, gender, serum LDL and HDL cholesterol levels, hypertension, smoking habit and diabetes mellitus. Data were analyzed in computer with SPSS programme. Multiple logistic regression technic was used in the analysis of the association. All independent variables mentioned above were entered in the logistic regression model. In order to express the odds ratio more meaningfully, magnesium and HDL cholesterol levels were considered as cathegoric variables. In the categorizations of magnesium values, the patients were divided into two groups: while in one group magnesium levels were between 1.2 and 1.7 mg/dl, in the other group magnesium levels were higher than 1.7 mg/dl. As a result of study, serum magnesium level was found to be negatively associated with carotid atherosclerosis. Those having serum magnesium levels higher than 1.7 mg/dl had an odds ratio of 0.11 22 for carotid atherosclerosis (p= 0.0007, 95% confidence interval: 0.0315- 0.3992, referent category included those having serum magnesium levels between 1.2-1.7 mg/dl). In order to see the consistency and the nature of the association new studies are needed.

Özet

Bu çalışma, iskemik inmeli hastalarda serum magnezyum düzeyi ile karotid arterlerdeki ateroskleroz arasında bir ilişkinin var olup olmadığını araştırmak amacı ile yapıldı. Çalışmaya iskemik inmeli 85 hasta dahil edildi (48 kadın, 37 erkek). Tüm hastalarda serum magnezyum düzeyleri ölçüldü ve bilateral karotis arterlerde renkli Doppler ultrasonografi incelemesi yapıldı.. Renkli Doppler ultrasonografi inceleme ile karotis arterlerde ileri intimal hiperplazi, plâk ve/veya stenozu olan 56 hasta vaka grubunu, normal bulunanlar ile minimal intimal hiperplazi saptanan 29 hasta ise kontrol grubunu oluşturdu. Serum magnezyum düzeyinin dışında dikkate alınan diğer bağımsız değişkenler: Yaş, cinsiyet, serumda LDL ve HDL kolesterol düzeyleri, hipertansiyon, sigara kullanım durumu ve diabetten oluşmaktaydı. Veriler SPSS yazılım programı aracılığı ile bilgisayarda analiz edildi, ilişki analizinde çoklu (multiple) lojistik regresyon tekniği kullanıldı.Yukarıda belirtilen tüm değişkenler lojistik regresyon modeline dahil edildi, ilgili odds ratio'u anlaşılır ifade ile sunabilmek için Mg ve HDL-kolesterol düzeyleri kategorik değişkenler olarak ele alındı. Mg düzeyi 1.2 ile 1.7 mg/dl arasında olan 42 kişi bir grup, 1.7 mg/dl'den yüksek olan 43 kişi diğer grup olacak şekilde gruplandırıldı. Referans kategori serum Mg düzeyi 1.2- 1.7 mg/dl iken serum Mg düzeyi 1.7 mg/dl'den yüksek olanlar için karotis aterosklerozu odds ratio'su: 0.1122 olarak hesaplandı (p=0.0007, %95 güven aralığı: 0.0315-0.3992 ). Serum magnezyum düzeyi ve karotis aterosklerozu arasında saptanan bu negatif (ters yönlü) ilişkinin, kararlılığını ve tabiatını ortaya koyacak yeni çalışmalara gereksinim vardır.

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Cite This Article

TOPAKTAŞ, S., SEZER, E., TAŞ, A., TAŞ, F. (2022). The relationship between serum magnesium level and atherosclerosis of carotid arteries in ischemic stroke cases. Türk Beyin Damar Hastalıkları Dergisi, Cilt: 6 - Sayı: 3, 71–76. https://ajindex.com/articles/620340

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