Journals / Türk Beyin Damar Hastalıkları Dergisi / 2021 / Cilt: 27 - Sayı: 3

RELATIONSHIP BETWEEN INTRACRANIAL ARTERIAL CALCIFICATION AND SERUM ALKALINE PHOSPHATASE LEVELS

İNTRAKRANİYAL ARTERİYEL KALSİFİKASYON İLE SERUM ALKALEN FOSFATAZ SEVİYELERİNİN İLİŞKİSİ

Pages
200–209
Publication Date
2022-11-06
DOI
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RESULTS: In this study, the average ALP level of the group with calcification (88,2 ± 28 U/L) was higher than the group of without calcification (60,4 ± 17,2 U/L) (p

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Objective & Hypothesis:INTRODUCTION: In this study, whether there is a relationship between serum ALP levels and intracranial arterial calcification was investigated.
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Key Findings & Data:METHODS: Here, 504 patients who applied to our hospital were included.
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Conclusion & Impact:RESULTS: In this study, the average ALP level of the group with calcification (88,2 ± 28 U/L) was higher than the group of without calcification (60,4 ± 17,2 U/L) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: In this study, whether there is a relationship between serum ALP levels and intracranial arterial calcification was investigated. METHODS: Here, 504 patients who applied to our hospital were included. These patients were divided into two main groups by whether they had intracranial arterial calcification (IAC) or not. Those with calcifications were divided into two subgroups (mild-moderate and severe calcifications) according to the their IAC burden. To calculate IAC burden on non- contrast brain CT, calcifications that were less than 50% of the intracranial vessels wall were assigned one point; and calcifications that were equal to or more than 50% were assigned two points for each artery (ICA, MCA, ACA, PCA, VA and BA) evaluated. Those with IAC burden less than three points were interpreted as mild-to-moderate calcification and those with more than or equal to 3 points were interpreted as severe calcification. Demographic characteristics, stroke risk factors, ALP levels and IAC burden of all groups were compared. The results were evaluated with chi-square, two independent samples t-test, Mann-Whitney U, Kruskal Wallis and Spearman’s rho tests. Binary logistic regression analysis was also performed. RESULTS: In this study, the average ALP level of the group with calcification (88,2 ± 28 U/L) was higher than the group of without calcification (60,4 ± 17,2 U/L) (p

Özet

GİRİŞ ve AMAÇ: Bu çalışmada, intrakraniyal arteriyel kalsifikasyon (İAK) ile serum ALP seviyeleri arasında bir ilişki olup olmadığı incelendi. YÖNTEM ve GEREÇLER: Burada, çeşitli sebeplerle iki yıl boyunca hastanemize başvurmuş olan 504 hastanın verileri incelendi. Hastalar İAK olanlar ve olmayanlar olarak iki ana gruba ayrıldı. Ayrıca kalsifikasyonu olanlar İAK yüküne göre “hafif-orta ve ciddi kalsifikasyonları olanlar” şeklinde iki alt gruba ayrıldı. İAK yükünü hesaplamak için kontrastsız beyin BT’de intrakraniyal damar duvarında %50’den az olan kalsifikasyonlara bir puan; %50 veya daha fazla olan kalsifikasyonlara iki puan verildi. Sonra bu puanlar toplanarak İAK yükü hesaplandı. İAK yükü üç puanın altında olanlar hafif-orta kalsifikasyon; üç ve üzerinde puanı olanlar ciddi kalsifikasyon olarak yorumlandı. Tüm grupların demografik özellikleri, inme risk faktörleri, ALP düzeyleri ve İAK yükü karşılaştırıldı. Bulgular ki-kare, bağımsız iki örneklem t testi, Mann-Whitney U, Kruskal Wallis ve Spearman’s rho testleri ile değerlendirildi. Regresyon analiz yöntemi olarak binary logistik regresyon analizi uygulandı. BULGULAR: Bu çalışmada, kalsifikasyonu olan grubun ALP ortalaması (88,2 ± 28 U/L); kalsifikasyonu olmayan grubun (60,4 ± 17,2 U/L) ALP ortalamasından daha yüksek bulundu (p

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Cite This Article

GÖKÇE, M., ŞAHİN, H. (2022). RELATIONSHIP BETWEEN INTRACRANIAL ARTERIAL CALCIFICATION AND SERUM ALKALINE PHOSPHATASE LEVELS. Türk Beyin Damar Hastalıkları Dergisi, Cilt: 27 - Sayı: 3, 200–209. https://ajindex.com/articles/620297

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