Journals / Türk Beyin Damar Hastalıkları Dergisi / 2021 / Cilt: 27 - Sayı: 2

TIME TO DIAGNOSIS OF CANCER IN STROKE PATIENTS

İNME HASTALARINDA KANSER TANI ZAMANI

Pages
160–168
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Particular consideration should be given to the potential diagnosis of cancer in the 1- year follow-up of patients after having a stroke.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:INTRODUCTION: Stroke and cancer are diseases that lead to disability and mortality in society.
📊
Key Findings & Data:We aimed to identify the clinical characteristics of patients who had a stroke under a known cancer diagnosis and stroke patients who were found to have cancer at the same time or during the 1-year post-stroke follow-up period.
💡
Conclusion & Impact:Particular consideration should be given to the potential diagnosis of cancer in the 1- year follow-up of patients after having a stroke.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: Stroke and cancer are diseases that lead to disability and mortality in society. We aimed to identify the clinical characteristics of patients who had a stroke under a known cancer diagnosis and stroke patients who were found to have cancer at the same time or during the 1-year post-stroke follow-up period. Stroke patients with cancer were compared with non-cancerous stroke patients. (not diagnosed with cancer during a 5-year follow-up) METHODS: Age, sex, subtype of stroke, conventional risk factors (CRF), localization, cancer types, presence of metastasis, duration between cancer-stroke diagnoses, mortality, and stroke-death periods were analysed. RESULTS: Fifty-seven stroke patients (35M, 22F) with cancer and 295 stroke patients (154F, 141M) without cancer were included. Ischemic stroke was most common subtypes in stroke patients with cancer (89.4%). The presence of CRF and the comorbidity of diabetes mellitus and coronary artery disease in the patients without cancer was determined to be significantly higher compared to with cancer.(p=0.000,p=0.038,p=0.000) Bilateral hemisphere involvement was detected to be significantly higher in the stroke with cancer.(p=0.012) Forty-two of the stroke patients with cancer were diagnosed with cancer before (25.9±32.4months), and 15 of them were diagnosed with cancer after the diagnosis of stroke (5.2±4.9months). Six of 15 patients were diagnosed with the cancer at the same time with the diagnosis of the stroke, while 9 of them were diagnosed with cancer during the post-stroke 1-year follow-up. The rate of females was determined to be significantly higher in the group diagnosed with cancer before having a stroke compared to after having a stroke.(p=0.003) 40.4% of stroke patients with cancer died in 6.7±12.3months. DISCUSSION AND CONCLUSION: The absence of CRF and bilateral hemisphere involvement should make us think of the coexistence of cancer and stroke. Particular consideration should be given to the potential diagnosis of cancer in the 1- year follow-up of patients after having a stroke.

Özet

GİRİŞ ve AMAÇ: İnme ve kanser hastalıkları toplumda engelliğe ölüm yol açan hastalıklardır. Bilinen bir kanser tanısı altında inme geçiren hastalar ile aynı zamanda veya inme sonrası 1 yıllık takip döneminde kanser tespit edilen inme hastalarının klinik özelliklerini belirlemeyi amaçladık. Kanserli olan inme hastaları, kanserli olmayan inme hastaları (5 yıllık takipte kanser tanısı almayan) ile karşılaştırıldı. YÖNTEM ve GEREÇLER: Yaş, cinsiyet, inme alt tipi, geleneksel risk faktörleri (GRF), lokalizasyon, kanser tipleri, metastaz varlığı, kanser inme teşhisleri arasındaki süre, mortalite ve inme-ölüm arası süreler değerlendirildi. BULGULAR: Kanserli inme olan 57 hasta (35E, 22K), kansersiz inme tanısı olan 295 hasta (154K, 141E) alındı. İskemik inme, kanserli inmelerde en sık görülen alt tip idi. (%89.4) Kansersiz inme grubunda, GRF varlığı ve diabetes mellitus, koroner arter hastalığı komorbiditeleri kanserli inme grubundan anlamlı olarak yüksek saptandı.(p=0.000,p=0.038, p=0.000) Kanserli inme olan grupta bilateral hemisfer tutulum oranı kansersiz inmelere göre anlamlı düzeyde yüksek saptandı.(p=0.012) Kanserli inme olan hastaların 42’sinin daha önce kanser tanısı (25.9±32.4ay) aldığı, 15’inin inme tanısından sonra kanser tanısı (5.2±4.9ay) aldığı tespit edildi. Onbeş hastanın 6’sının inme ile aynı zamanda, 9’unun ise inme sonrası izlemde kanser tanısı aldığı kaydedildi. İnme öncesi kanser tanısı alan grupta kadın cinsiyetin inme sonrası kanser tanısı alan gruba göre anlamlı düzeyde yüksek olduğu saptandı.(p=0.003) Kanserli inme hastalarının %40.4’ünün inmeden sonra 6.7±12.3 ayda eksitus oldu. TARTIŞMA ve SONUÇ: GRF'nin olmaması ve bilateral hemisfer tutulumu bize kanser ve inmenin birlikteliğini düşündürmelidir. Özellikle hastaların inme sonrası 1 yıllık izlemlerinde potansiyel kanser tanısı açısından dikkatli olunmalıdır.

🔖

Cite This Article

AYAS, Z. Ö., UNCU, G. (2022). TIME TO DIAGNOSIS OF CANCER IN STROKE PATIENTS. Türk Beyin Damar Hastalıkları Dergisi, Cilt: 27 - Sayı: 2, 160–168. https://ajindex.com/articles/620293

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Grisold W, Oberndorfer S, Struhal W. Stroke and cancer: A review. Acta Neurol Scand 2009; 119(1): 1-16
  2. Taccone FS, Jeangette SM. Blecic SA. First-ever stroke as initial presentation of systemic cancer. J Stroke Cerebrovasc Dis 2008; 17(4):169-174
  3. Dipasco PJ, Misra S, Koniaris LG, et al. Thrombophilic state in cancer, part I: Biology, incidence and risk factors. J Surg Oncol 2011; 104(3): 316-322
  4. Graus F, Rogers LR, Posner JB. Cerebrovascular complications in patients with cancer. Medicine (Baltimore) 1985; 64: 16-35
  5. Kneihsl M, Enzinger C, Wünsch G, et al. Poor short-term outcome in patients with ischaemic stroke and active cancer. J Neurol 2016; 263(1): 150-156
  6. Cerrahoğlu T Ş, Güler A, Şirin H, et al. Stroke and cancer association: Analysis of 30 patients. Ege Journal of Medicine 2013; 52(3): 155-159
  7. Zaorsky NG, Zhang Y, Tchelebi LT, et al. Stroke among cancer patients. Nat Commun. 2019; 10(1): 5172
  8. Rogers LR. Cerebrovascular complications in patients with cancer. Semin Neurol. 2010; 30(3): 311-319
  9. Dardiotis E, Alozou AM, Markoula S, et al. Cancerassociated stroke: Pathophysiology, detection and management (Review). Int J Oncol 2019; 54(3): 779-796
  10. Nazlıel B. Cancer, paraneoplastic syndromes and stroke. Turkiye Klinikleri J Neurol-Special Topics 2014; 7(4): 125- 131
  11. Aarnio K, Joensuu H, Haapaniemi E, et al. Cancer in young adults with ischemic stroke. Stroke 2015; 46(6): 1601- 1606
  12. Katz JM, Segal AZ. Incidence and etiology of cerebrovascular disease in patients with malignancy. Curr Atheroscler Rep 2005; 7(4): 280-288
  13. Bang YO, Chung JW, Lee MJ, et al. Cancer-Related Stroke: An emerging subtype of ischemic stroke with unique pathomechanisms. J Stroke 2020; 22(1): 1-10
  14. Grazioli S, Paciaroni M, Agnelli G, et al. Cancer-associated ischemic stroke: A retrospective multicentre cohort study. Thromb Res. 2018; 165: 33-37
  15. Nilsson G, Holmberg L, Garmo H, et al. Increased incidence of stroke with breast cancer. Eur J Cancer 2005; 41(3): 423- 429
  16. Newton HB: Neurologic complications of systemic cancer. Am Fam Physician 1999; 59(4): 878-886
  17. Arboix A: Cerebrovascular disease in the cancer patient. Rev Neurol 2000; 31(12): 1250-1252. Diagnosis of cancer in stroke patients 18. Chaturvedi DM, Ansell J, Recht L. Should cerebral ischemic events in cancer patients be considered a manifestation of hypercoagulability? Stroke 1994; 25(6): 1215-1218
  18. Stefan O, Vera N, Otto B, et al. Stroke in cancer