Journals / Türk Beyin Damar Hastalıkları Dergisi / 2022 / Cilt: 28 - Sayı: 1

ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE

COVİD-19 HASTALARINDA İSKEMİK İNME: TEK MERKEZİN BİR YILLIK TECRÜBESİ

Pages
23–30
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Moreover, higher age, women gender, LVO in neuroimagining, high CRP, Ferritin, D-dimer levels, COVID-19 RT-PCR positivity, presence of hypertension and atrial fibrillation comorbidities showed poor outcome.

📌 3 Key Takeaways

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Objective & Hypothesis:INTRODUCTION: The clinical presentation of COVID-19 varies greatly.
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Key Findings & Data:We aim to describe the features of COVID-19 positive ischemic stroke patients of 1-year experiences of a single center.
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Conclusion & Impact:Moreover, higher age, women gender, LVO in neuroimagining, high CRP, Ferritin, D-dimer levels, COVID-19 RT-PCR positivity, presence of hypertension and atrial fibrillation comorbidities showed poor outcome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: The clinical presentation of COVID-19 varies greatly. Even though, disease cause predominantly respiratory manifestations, because of the inflammatory nature of the disease, it also triggers thromboembolic conditions. We aim to describe the features of COVID-19 positive ischemic stroke patients of 1-year experiences of a single center. METHODS: A total of 258 patients, diagnosed with ischemic cerebrovascular disease (25 patients of with strokes had respiratory symptoms at initial presentation and COVID-19 diagnosis), were evaluated retrospectively during the study period. RESULTS: A majority of these patients strokes were in anterior circulation territory and most of them were large vessel occlusion. Eighteen of the patients had positive COVID-19 RT-PCR results, while 7 of the patients had negative results but their thorax CTs made the diagnosis of COVID-19. Hypertension (56%), diabetes (44%), and atrial fibrillation (44%) were the most comorbidities. Thirteen patients stroke etiology was cardioembolism, 9 had atherosclerosis. Fourteen of the patients NIHSS were >10, and 13 of them died. Patients with high levels of CRP (13/25), D-Dimer (15/25) and Ferritin (14/25) had mRS>3 at admission. Most of the patients (19/25) had CO-RADS 5 scores at admission. Two patients had mRS 4-5, 9 patients had mRS 0-3 at the discharge period. Fourteen patients died at the hospital period. DISCUSSION AND CONCLUSION: The admission NIHSS scores determined significantly the prognosis. Moreover, higher age, women gender, LVO in neuroimagining, high CRP, Ferritin, D-dimer levels, COVID-19 RT-PCR positivity, presence of hypertension and atrial fibrillation comorbidities showed poor outcome.

Özet

GİRİŞ ve AMAÇ: COVİD-19’un klinik özellikleri değişkenlik göstermektedir. Hastalık sıklıkla solunum sistemi semptomları ile prezente olmakla birlikte hastalığın inflamatuar doğası sonucu tromboembolik olaylar da tetiklenebilmektedir. Çalışmamızda bir yıl içerisinde merkezimizde tanı alan ve COVİD-19 ile birliktelik gösteren iskemik inme hastalarının klinik özelliklerini tanımlamayı amaçladık. YÖNTEM ve GEREÇLER: Kliniğimizde bir yıl boyunca iskemik serebrovasküler hastalık tanısı konulan toplam 258 hasta geriye dönük olarak tarandı. Bu hastaların klinik, laboratuar ve görüntüleme bulguları retrospektif olarak değerlendirildi. Toplam 25 hasta COVİD-19 tanısı almış olup, çalışmaya dahil edilmiştir. BULGULAR: Hastalardan 18'inin COVID-19 RT-PCR sonucu pozitif olarak, 7'sinin ise negatif olmasına rağmen toraks BT'lerinde tipik COVID-19 pnömoni bulguları olması nedeniyle klinik ve radyolojik olarak tanı konulmuştur. Hastaların çoğunluğunda anterior dolaşımda, geniş damar oklüzyonu sonucu enfarkt oluşumu gözlenmiştir. En sık eşlik eden hastalıklar hipertansiyon (%56), diyabet (%44) ve atriyal fibrilasyon (%44) olarak belirlenmiştir. On üç hastada kardiyoembolizm, 9 hastadaysa ateroskleroz inme etyolojisi olarak tespit edilmiştir. NIHSS skoru 10’un üzerinde olan 14 hastadan 13’ü mortal seyretmiştir. CRP (13/25), D-Dimer (15/25) ve Ferritin (14/25) düzeyleri yüksek olan hastalarda mRS>3 bulunmuştur. Hastaların çoğunda (19/25) Toraks BT görüntüleme bulgusu CORADS 5 olarak değerlendirilmiştir. Taburculuk döneminde iki hastada mRS 4-5, 9 hastada mRS 0-3 şeklindedir. Toplamda 14 hasta ise mortal seyretmiştir. TARTIŞMA ve SONUÇ: Prognozu belirlemede önemli parametrelerden biri ilk değerlendirmedeki NIHSS skorları olduğu düşünülmektedir. Ayrıca, ileri yaş, kadın cinsiyet, beyin görüntülemede geniş damar oklüzyonu varlığı, yüksek CRP, Ferritin, D-dimer seviyeleri, COVID-19 RT-PCR pozitifliği, hipertansiyon ve atriyal fibrilasyon komorbiditeleri olan hastaların prognozu kötü seyretmiştir.

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Cite This Article

ÇUBUK, H. S., ÇUBUK, C., ALTIPARMAK, T. (2022). ISCHEMIC STROKE IN COVID-19 PATIENTS: SINGLE CENTER, ONE YEAR EXPERIENCE. Türk Beyin Damar Hastalıkları Dergisi, Cilt: 28 - Sayı: 1, 23–30. https://ajindex.com/articles/620273

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