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Journals / Tüberküloz ve Toraks / 2006 / Cilt: 54 - Sayı: 2

Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers

Stabil kronik obstrüktif akciğer hastalığı olan hastalar ile sigara içenlerde hava yolu inflamasyonu ve lenfosit alt tiplerinin analizi

Taci Nevin HOCA
Filiz ÇİMEN
Şükran ATİKCAN
Melike ATASEVER
Mustafa BALCI
Tuğrul ŞİPİT
Ahmet Selim YURDAKUL
Pages
122–127
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, the most marked cellular change in BAL of subjects with stable COPD is the increase in neutrophils and decrease in macrophages, suggesting a very important role in the chronic airflow limitation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Chronic airway inflammation is reported to have an important role for the development of chronic obstructive pulmonary disease (COPD), in addition to smoking, genetic and environmental factors.
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Key Findings & Data:A total of 35 subjects (18 patients with COPD and 17 healthy smokers) were enrolled in this study.
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Conclusion & Impact:As a result, the most marked cellular change in BAL of subjects with stable COPD is the increase in neutrophils and decrease in macrophages, suggesting a very important role in the chronic airflow limitation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Chronic airway inflammation is reported to have an important role for the development of chronic obstructive pulmonary disease (COPD), in addition to smoking, genetic and environmental factors. The present study was aimed to investigate whether the airway inflammation differed in subjects with stable COPD and healthy smokers. A total of 35 subjects (18 patients with COPD and 17 healthy smokers) were enrolled in this study. Bronchoalveolar lavage (BAL) was performed via fiberoptic bronchoscope in all subjects and cell counts and profiles and lymphocyte subset were analyzed in BAL fluids. The number of neutrophils in BAL of subjects with stable COPD was significantly higher than that of the healthy smokers (p 0.05). As a result, the most marked cellular change in BAL of subjects with stable COPD is the increase in neutrophils and decrease in macrophages, suggesting a very important role in the chronic airflow limitation.

Özet

Kronik obstrüktif akciğer hastalığı (KOAH) gelişiminde, sigara içimi, genetik ve çevresel etkenlerin yanında, hava yollarında oluşan kronik inflamasyonun da rolü olduğu belirtilmektedir. Bu çalışmada, KOAH’ı olan olgular ile sigara içen sağlıklı kişiler arasında hava yollarında oluşan inflamasyonun farklı olup olmadığını araştırmak amaçlandı. Çalışmaya KOAH tanısı konulan 18 hasta ile sigara içen, ancak KOAH gelişmemiş 17 kişi olmak üzere toplam 35 olgu alındı. Olguların tümüne fiberoptik bronkoskopi (FOB) uygulanarak bronkoalveoler lavaj (BAL) alındı. BAL sıvılarında hücre sayımı ve dağılımı ile lenfosit alt tiplerinin analizi yapıldı. Stabil KOAH’lı olguların BAL sıvısındaki nötrofil sayısının sağlıklı sigara içen gruba göre anlamlı düzeyde yüksek olduğu (p 0.05). Sonuç olarak; stabil KOAH’lı olguların BAL sıvısındaki en önemli hücresel değişiklik, kronik hava akımı kısıtlamasında çok önemli bir rolü olan nötrofillerin artış göstermesi ve makrofajların azalmasıdır.

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Cite This Article

HOCA, T. N., ÇİMEN, F., ATİKCAN, Ş., ATASEVER, M., BALCI, M., ŞİPİT, T., YURDAKUL, A. S. (2022). Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers. Tüberküloz ve Toraks, Cilt: 54 - Sayı: 2, 122–127. https://ajindex.com/articles/619155

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