Journals / Tüberküloz ve Toraks / 2006 / Cilt: 54 - Sayı: 1

C-reactive protein, leukocyte count and ESR in the assessment of severity of community-acquired pneumonia

Toplum kökenli pnömonilerin ağırlığının değerlendirilmesinde C-reaktif protein, lökosit sayısı ve eritrosit sedimentasyon hızının yeri

Pages
22–29
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is considered that CRP, a powerful marker of inflammation, is related with severity of pneumonia and a high level of CRP may be useful to make a decision about hospitalisation.

📌 3 Key Takeaways

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Objective & Hypothesis:This study aimed to evaluate the relations between the levels of CRP, leukocyte count and ESR on admission and the severity of pneumonia according to the criteria of Turkish Thoracic Society (TTS) and British Thoracic Society (BTS) CAP guidelines.
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Key Findings & Data:This study included the adult patients with CAP admitted to our clinic between the years 2003-2005.
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Conclusion & Impact:It is considered that CRP, a powerful marker of inflammation, is related with severity of pneumonia and a high level of CRP may be useful to make a decision about hospitalisation.
🔬Design:Research Article
📍Scope:2003-2005 Verileri
⚙️Variables:Domain Parameters

Abstract

This study aimed to evaluate the relations between the levels of CRP, leukocyte count and ESR on admission and the severity of pneumonia according to the criteria of Turkish Thoracic Society (TTS) and British Thoracic Society (BTS) CAP guidelines. This study included the adult patients with CAP admitted to our clinic between the years 2003-2005. The history, physical findings, hemogram, ESR, the levels of CRP and the results of other laboratory investigations were obtained from the medical records. The patients were grouped according to BTS and TTS guidelines. The mean age was 47.2 years; 70 patients (75.3%) were male and 23 patients (24.7%) were female. The severity of pneumonia according to BTS criteria was correlated with the levels of CRP and leukocyte count (p= 0.037, p= 0.01, respectively). The severity of pneumonia according to TTS criteria was correlated with the levels of CRP, leukocyte count and ESR (p= 0.000, p= 0.014, p= 0.015, respectively). Among TTS pneumonia groups, there were statistically significant differences between groups 1 and 3; groups 1 and 4; groups 2 and 3 (p= 0.006, p= 0.041, p= 0.05, respectively) for mean CRP levels. The mean levels of CRP (10^3.2 ± 76.4 mg/L), leukocyte count (19.8 ± 9.5 x 10^3/ìL) and ESR (57.2 ± 26.8 mm/hour) were statistically significantly higher in inpatients than the mean levels of CRP (53.2 ± 52.8 mg/dL), leukocyte count (14.6 ± 5.4 x 10^3/ìL) and ESR (43.1 ± 25.9 mm/hour) in outpatients (p= 0.000, p= 0.001, p= 0.012, respectively) according to TTS. It is considered that CRP, a powerful marker of inflammation, is related with severity of pneumonia and a high level of CRP may be useful to make a decision about hospitalisation.

Özet

Bu çalışmada, İngiliz Toraks Derneği (BTS) ve Türk Toraks Derneği (TTD) toplum kökenli pnömoni (TKP) tanı ve tedavi kılavuzlarına göre değerlendirilen olgularda, başvuru anındaki ortalama C-reaktif protein (CRP) düzeyi, lökosit sayısı ve eritrosit sedimentasyon hızı (ESH) değerleri ile pnömoni şiddeti arasındaki ilişkinin incelenmesi amaçlandı. Çalışmaya 2003-2005 yılları arasında kliniğimize başvuran erişkin yaştaki TKP olguları alındı. Başvuru anındaki öyküleri, fizik muayene bulguları, hemogram, ESH, CRP düzeyleri ve diğer tetkik sonuçları hasta dosyalarından sağlandı. Hastalar BTS ve TTD kılavuzlarına göre gruplandırıldı. Hastaların 70 (%75.3)’i erkek, 23 (%24.7)’ü kadındı (ortalama yaş: 47.2 yıl). BTS’ye göre pnömoni şiddeti ile CRP ve lökosit sayısı (sırasıyla p= 0.037, p= 0.01), TTD’ye göre pnömoni şiddeti ile CRP, lökosit sayısı ve ESH düzeyleri (sırasıyla p= 0.000, p= 0.014, p= 0.015) arasında pozitif korelasyon olduğu bulundu. TTD pnömoni gruplarında, ortalama CRP düzeyi yönünden grup 1 ve 3 arasında; grup 1 ve 4 arasında; grup 2 ve 3 arasında (sırasıyla p= 0.006, p= 0.041, p= 0.05) istatistiksel olarak anlamlı farklılık saptandı. TTD’ye göre hastanede yatarak tedavi uygulanan hastalarda ortalama CRP (103.2 ± 76.4 mg/L), lökosit (19.8 ± 9.5 x 10^3/µL) ve ESH (57.2 ± 26.8 mm/saat) değerlerinin ayakta tedavi uygulanan hastalardaki ortalama CRP (53.2 ± 52.8 mg/dL), lökosit (14.6 ± 5.4 x 10^3/µL ) ve ESH (43.1 ± 25.9 mm/saat) değerlerinden istatistiksel olarak anlamlı düzeyde yüksek oldukları tespit edildi (sırasıyla p= 0.000, p= 0.001, p= 0.012). İnflamasyonun kuvvetli bir göstergesi olan CRP düzeyinin pnömoninin şiddeti ile ilişkili olduğu ve yüksek düzeylerinin hastaneye yatış kararında yararlı olabileceği düşünüldü.

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Cite This Article

AKKAYA, A., GÖKIRMAK, M., KAYA, Ö., ÖZTÜRK, Ö., ŞAHİN, Ü., BİRCAN, A. (2022). C-reactive protein, leukocyte count and ESR in the assessment of severity of community-acquired pneumonia. Tüberküloz ve Toraks, Cilt: 54 - Sayı: 1, 22–29. https://ajindex.com/articles/619143

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References (16)

  1. loachimescu OC, loachimescu AG, lannini PB. Severity scoring in community-acquired pneumonia caused by Streptococcus pneumonia: a 5-year experience. Int J Antimicrob Agents 2004
  2. British Thoracic Society Research Committee. Community-acquired pneumonia in adults in British hospitals in 1982-83: A survey of aetiology, mortality, prognostic factors and outcome. Q J Med 1987
  3. Fine MJ, Smith MA, Carson CA, et al. Prognosis and out­comes of patients with community-acquired pneumonia. JAMA 1996
  4. Requilme R, Torres A, El-Elbiary M, et al. Community-ac­quired pneumonia in the elderly. A multivariate analysis of risk and prognostic factor. Am J Respir Crit Care Med 1996
  5. American Thoracic Society. Guidelines for the manage­ment of adults with community-acquired pneumonia: diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 2001
  6. British Thoracic Society Standards of Care Committee. BTS guidelines for the management of community-acquired pneumonia in adults. Thorax 2001
  7. 56 (Suppl IV): 1-64. 7.Fine MJ, Auble TE, Yealy DM, et al. A prediction rule toidentify low-risk patients with community-acquired pneumonia. N Engl J Med 1997
  8. Toraks Derneği. Erişkinlerde toplum kökenli pnömoni tanı ve tedavi rehberi. Toraks Dergisi 2002
  9. 3 (Ek 3): 1-15. 9.Stahl WM. Acute phase protein response to tissue injury. Crit Care Med 1987
  10. Vazquez GE, Martinez JA, Mensa J, et al. C-reactive protein levels in community-acquired pneumonia. Eur Respir J 2003
  11. Ay M, Gürbilek M, Vatansev H. Akut faz proteinleri. Genel Tıp Dergisi 1998
  12. Castel JV, Gomez-Lechon MJ, David M, et al. Acute phase response of human hepatocytes: Regulation of acutephase protein synthesis by interleukin-6. Hepatology 1990
  13. Hansson LO, Lindquist L C-reactive protein: It's role in the diagnosis and follow-up of infectious diseases. Curr Opin Infect Dis 1997
  14. Almirall J, Bolibar I, Toran P, et al. Community-Acquired Pneumonia Maresme Study Group. Contribution of C-reactive protein to the diagnosis and assessment of severity of community-acquired pneumonia. Chest 2004
  15. Lehtomaki K, Leinonen M, Takala A, et al. Etiological diagnosis of pneumonia in military conscripts by combined use of bacterial culture and serological methods. Eur J Clin Microbiol Infect Dis 1988
  16. Smith RP, Lip worth