Journals / Tüberküloz ve Toraks / 2008 / Cilt: 56 - Sayı: 4

Churg-Strauss syndrome associated with montelukast

Montelukast ile ilişkili Churg Strauss sendromu

Pages
434–438
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We present this case of CSS associated with montelukast in whom spontaneous remission was observed without using corticosteroids and cytotoxic agents.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A 47 year old woman who had a history of asthma for 15 years referred to our hospital because of infiltrates on her chest radiograph that not responded to antibiotic treatment.
📊
Key Findings & Data:We found that she had eosinophilia in peripheral blood (38%) and bronchoalveolar lavage (54%), nasal polyposis, and transient pulmonary infiltrates, and in the base of these findings we diagnosed as Churg-Strauss Syndrome (CSS).
💡
Conclusion & Impact:We present this case of CSS associated with montelukast in whom spontaneous remission was observed without using corticosteroids and cytotoxic agents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A 47 year old woman who had a history of asthma for 15 years referred to our hospital because of infiltrates on her chest radiograph that not responded to antibiotic treatment. We found that she had eosinophilia in peripheral blood (38%) and bronchoalveolar lavage (54%), nasal polyposis, and transient pulmonary infiltrates, and in the base of these findings we diagnosed as Churg-Strauss Syndrome (CSS). She has been using montelukast for 2 years. By examining her previous medical records, we observed that while eosinophil rates in peripheral blood were normal before montelukast usage, after this therapy eosinophil rates were greater 10 percent. Therefore, we thought that CSS was to be associated with montelukast usage. After just montelukast therapy was discontinued, clinical and radyographic parameters and the eosinophil counts (20%) improved. We present this case of CSS associated with montelukast in whom spontaneous remission was observed without using corticosteroids and cytotoxic agents.

Özet

On beş yıldır astım öyküsü olan 47 yaşında bir kadın hasta antibiyotik tedavisine yanıt vermeyen radyolojik infiltrasyonu nedeniyle hastanemize sevkedildi. Hasta 2 yıldır montelukast kullanıyordu. Periferik kanda eozinofili (%38), bronkoalveoler lavajda eozinofili (%54), nazal polip, akciğer grafisinde geçici infiltrasyonlar saptanması üzerine Churg-Strauss Sendromu (CSS) tanısı koyduk. Hastanın montelukast kullanmadan önceki periferik kan incelemelerindeki eozinofil oranları normal iken, ilacı kullanmaya başladıktan sonra eozinofil oranlarının %10’un üzerinde seyrettiği eski kayıtların incelenmesi ile öğrenildi. Bu hastada CSS’nin montelukast kullanımı ile ilişkili olduğu düşünüldü. Sadece montelukast tedavisinin kesilmesi ile hastanın klinik ve radyolojik bulgularında, eozinofil sayısında düzelme (%20) sağlandı. Kortikosteroid veya sitotoksik tedavi vermeksizin iyileşme gösteren montelukast kullanımı ile ilişkili CSS’li bu olguyu sunmayı uygun bulduk.

🔖

Cite This Article

ESKİTÜTÜNCÜ, B., SOY, M., KURTAR, N., ÖZDEMİR, L., ÖZLEN, B., ÇEVİRME, L., HATİPOĞLU, N. O. (2022). Churg-Strauss syndrome associated with montelukast. Tüberküloz ve Toraks, Cilt: 56 - Sayı: 4, 434–438. https://ajindex.com/articles/619018

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (19)

  1. Cordier JF. Pulmonary vasculitis. In: Olivieri D, duBois RM (eds). Interstitial Lung Diseases. EMonograph of European Respiratory 2000; 14: 226-43
  2. Lynch III JP, Leatherman JW. Alveolar hemorrhage. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM (eds). Fishman’s Pulmonary Diseases and Disorders. 3rd ed. New York: McGraw-Hill, 1998: 1193-210
  3. O’Byrne PO, Israel E, Drazen JM. Antileukotriene in the treatment of asthma. Ann Intern Med 1997; 127: 472-80
  4. Green R, Vayonis AG. Churg-Strauss syndrome after zafirlukast in two patients not receiving systemic steroid treatment. Lancet 1999; 353: 725-6
  5. Rochester CL. The eosinophilic pneumonias. In: Fishman AP (ed). Fishman’s Pulmonary Diseases and Disorders. M New York: Mc Graw-Hill Company, 1998: 1133-50
  6. Allen JN, Davis WB. Eosinophilic lung diseases. Am J Respir Crit Care Med 1994; 50: 1423-38
  7. Chumbley LC, Harrison EG Jr, DeRemee RA. Allergic granulomatosis and angiitis (Churg-Strauss syndrome): Report and analysis of 30 cases. Mayo Clin Proc 1977; 52: 477-84
  8. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis and periarteritis nodosa. Am J Pathol 1951; 27: 277-301
  9. Katzenstein AL. Diagnostic features and differential diagnosis of Churg-Strauss syndrome in the lung. Am J Clin Pathol 2000; 114: 767-72
  10. Sullivan EJ, Hoffman GS.Pulmonary vasculitis. Clin Chest Med 1998; 19: 759-76
  11. Guillevin L, Cohen P, Gayraud M, et al. Churg-Strauss syndrome. Clinical study and long-term follow up of 96 patients. Medicine 1999; 78: 26-37
  12. Ramakrishna G, Connolly HM, Tazelaar HD, Mullany CJ, Midthun DE. Churg-Strauss syndrome complicated by eosinophilic endomyocarditis. Mayo Clin Proc 2000; 75: 631-5
  13. Cottin V, Cordier JF. Churg-Strauss syndrome. Allergy 1999; 54: 535 51
  14. Çildağ O, Polatlı M, Karadağ F ve ark. Churg Strauss sendromu: Klaritromisin tetikleyici faktör mü? Toraks Dergisi 2000; 3: 56-66
  15. Lipworth BJ. Leukotriene-receptor antagonists. Lancet 1999; 353: 57-62
  16. Wechsler ME, Garpestad E, Flier SR, et al. Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA 1998; 279: 455-7
  17. Honsinger RW. Zafirlukast and Churg-Strauss syndrome. JAMA 1998; 279: 1949
  18. Franco J, Artés MJ. Pulmonary eosinophilia associated with montelukast. Thorax 1999; 54: 558-60
  19. Stirling RG, Chung KF. Leukotriene antagonists and Churg-Strauss syndrome: The smoking gun.