Journals / Tüberküloz ve Toraks / 2009 / Cilt: 57 - Sayı: 2

Current strategies for the diagnosis and treatment of acute respiratory distress syndrome

Akut solunum sıkıntısı sendromu tanısı ve tedavisinde güncel yaklaşımlar

Pages
228–236
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fluid restriction and immunonutrition should be considered when these patients are being cared for.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Acute respiratory distress syndrome is a frequently encountered condition in the intensive care units, with high mortality rates despite cumulating knowledge on its pathogenesis.
📊
Key Findings & Data:Different mechanical ventilation strategies, as well as agents for the control of inflammation are being tested.
💡
Conclusion & Impact:Fluid restriction and immunonutrition should be considered when these patients are being cared for.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Acute respiratory distress syndrome is a frequently encountered condition in the intensive care units, with high mortality rates despite cumulating knowledge on its pathogenesis. It is important that cardiac pulmonary edema should be ruled out for diagnosis. Different mechanical ventilation strategies, as well as agents for the control of inflammation are being tested. Currently, low tidal volume ventilation with high PEEP and plateau pressures below 30 cmH2O is the only intervention that has been shown to improve survival significantly. Low dose steroids, nitric oxide inhalation, surfactant, antioxidants, β2 adrenergic agents, HMG-CoA reductase inhibitors are promising agents. Fluid restriction and immunonutrition should be considered when these patients are being cared for.

Özet

Akut solunum sıkıntısı sendromu yoğun bakımlarda sık karşılaşılan, patogeneziyle ilgili geniş bilgi birikimine rağmen hala etkin tedavisi gösterilememiş mortalitesi yüksek bir durumdur. Ayırıcı tanısında kardiyojenik pulmoner ödemin dışlanması önemlidir. Tedavisinde farklı mekanik ventilasyon uygulamaları ve inflamasyonun kontrolünü sağlayacak değişik ajanlar denenmektedir. Bugün için düşük tidal volüm ve 30 cmH2O’nun altında plato basınçları ile yapılan ventilasyonun, sağkalımı anlamlı olarak artırdığı gösterilmiş tek yaklaşımdır. Düşük doz steroid verilmesi, nitrik oksit inhalasyonu, sürfaktan uygulanması, çeşitli antioksidanlar, β2 adrenerjik ajanlar, HMG-CoA redüktaz inhibitörleri etkin olabileceği düşünülen ajanlardır. Bu hastaları izlerken sıvı kısıtlaması uygulanması ve immünnütrisyonun dikkate alınması önerilmektedir.

🔖

Cite This Article

ALTINTAŞ, D. N., İSKİT, T. A. (2022). Current strategies for the diagnosis and treatment of acute respiratory distress syndrome. Tüberküloz ve Toraks, Cilt: 57 - Sayı: 2, 228–236. https://ajindex.com/articles/618944

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-49
  2. Bernard GR, Artigas A, Brigham KL, et al. The American- European consensus conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-24
  3. Piantadosi CA, Schwartz DA. The acute respiratory distress syndrome. Ann Intern Med 2004; 141: 460-70
  4. Connors AF Jr, Speroff T, Dawson NV, et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT investigators. JAMA 1996; 276: 889-97
  5. Mueller C, Scholer A, Laule-Kilian K, et al. Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea. N Engl J Med 2004; 350: 647-54
  6. Aybar M, Altıntaş ND, İskit AT. Kardiyojenik ve nonkardiyojenik pulmoner ödem ayırıcı tanısında BNP ve pro-BNP’nin rolü
  7. Ulusal Dahili ve Cerrahi Bilimler Yoğun Bakım Sempozyumu. Yoğun Bakım Dergisi 2005; 5(Ek 1): 28
  8. Türkoğlu M. Kardiyojenik ve nonkardiyojenik pulmoner ödemin ayırıcı tanısında beyin natriüretik peptid ve Nterminal pro-beyin natriüretik peptidin rolü (tez). Yoğun Bakım Uzmanlık Tezi, Ankara: 2007
  9. Jain R, DalNogare A. Pharmacological therapy for acute respiratory distress syndrome. Mayo Clin Proc 2006; 81: 205-12
  10. Ranieri VM, Suter PM, Tortorella C, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial. JAMA 1999; 282: 54-61
  11. Ricard JD, Dreyfuss D, Saumon G. Ventilator-induced lung injury. Curr Opin Crit Care 2002; 8: 12-20
  12. Belperio JA, Keane MP, Lynch JP 3rd, Strieter RM. The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med 2006; 27: 350-64
  13. Slutsky AS, Tremblay LN. Multiple system organ failure. Is mechanical ventilation a contributing factor? Am J Respir Crit Care Med 1998; 157: 1721-5
  14. Santos CC, Zhang H, Liu M, Slutsky AS. Bench-to-bedside review: Biotrauma and modulation of the innate immune response. Crit Care (London, England) 2005; 9: 280-6
  15. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301-8
  16. Hager DN, Krishnan JA, Hayden DL, et al. Tidal volume reduction in patients with acute lu