Impaired myocardial performance in sarcoidosis

Objective & Hypothesis:Despite myocardial sarcoid involvement has been reported in 20 27% in autopsy series, only 5% of the patients are clinically symptomatic.

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Key Findings & Data:Seventy-two patients under follow-up for sarcoidosis without cardiac involvement (53 women, 19 men; mean age 49.1 ± 10.3 years) and nineteen age-matched healthy control subjects (14 women, 5 men; mean age 48.7 ± 6.5 years) were enrolled in the study.

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Conclusion & Impact:This can be related to a subclinical involvement of sarcoidosis.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Despite myocardial sarcoid involvement has been reported in 20 27% in autopsy series, only 5% of the patients are clinically symptomatic. This study was planned to evaluate right and left ventricular functions in patients with early stage sarcoidosis (stage I and II) without any findings of cardiac involvement with Tei index which globally shows systolic and diastolic functions of the ventricles was used. Seventy-two patients under follow-up for sarcoidosis without cardiac involvement (53 women, 19 men; mean age 49.1 ± 10.3 years) and nineteen age-matched healthy control subjects (14 women, 5 men; mean age 48.7 ± 6.5 years) were enrolled in the study. All subjects were evaluated with two-dimensional and Doppler echocardiography. Right and left ventricle Tei indices (myocardial performance index) were calculated from measured Doppler parameters. Peak velocity of the mitral A wave (A) was higher, peak velocity of the mitral E wave, E/A ratio were lower; and ejection time was shorter in patients with sarcoidosis (p 0.05). Left ventricular myocardial performance is disturbed in patients with early stage sarcoidosis. This can be related to a subclinical involvement of sarcoidosis.

Özet

Otopsi serlerinde %20-27 sıklıkta miyokardiyal sarkoid tutulum raporlanmasına rağmen olguların sadece %5inde klinik bulgular ortaya çıkmaktadır. Bu çalışma, kardiyak tutulumu bulunmayan evre I-II pulmoner sarkoidozlu olgularda, ventriküllerin sistolik ve diyastolik fonksiyonlarını global olarak gösteren Tei indeksi ile hem sağ hem de sol ventrikül fonksiyonlarını değerlendirmek amacıyla planlandı. Çalışmaya sarkoidoz nedeniyle takip edilmekte olan, kardiyak tutulumu olmayan 72 (53 kadın, 19 erkek; ortalama yaş 49.1 ± 10.3 yıl) hasta ve hastane personelinden yaşı uyumlu 19 sağlıklı gö- nüllü (14 kadın, 5 erkek; ortalama yaş 48.7 ± 6.5 yıl) dahil edildi. Olguların tümüne iki boyutlu ve Doppler ekokardiyografik değerlendirme yapıldı. Ölçülen Doppler parametrelerinden sol ve sağ ventrikül Tei indeksleri (miyokard performans indeksi) hesaplandı. Sarkoidozlu olgularda mitral A dalgasının zirve hızı (A) daha yüksek, mitral E dalgasının zirve hızı (E), E/A oranı daha düşük ve ejeksiyon zamanı daha kısa idi (p 0.05). Erken evre kardiyak tutulum olmayan sarkoidozlu olgularda sol ventrikülde miyokard performansı bozulmuştur. Bu durum subklinik bir sarkoid tutulumla ilişkili olabilir

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Cite This Article

COŞKUN, F., UZASLAN, E., YILMAZ, D., AYDIN, A. K., GÜLLÜLÜ, S. (2022). Impaired myocardial performance in sarcoidosis. Tüberküloz ve Toraks, Cilt: 58 - Sayı: 4, 401–407. https://ajindex.com/articles/618833

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References (15)

Handa T, Nagai S, Miki S, et al. Incidence of pulmonary hypertension and its clinical relevance in patients with Sarcoidosis. Chest 2006; 129: 1246-52
Musellim B, Kumbasar OO, Ongen G, et al. Epidemiological features of Turkish patients with sarcoidosis. Respir Med 2009; 103: 907-12
Fahy GJ, Marwick T, McCreery CJ, et al. Doppler echocardiographic detection of left ventricular diastolic dysfunction in patients with pulmonary Sarcoidosis. Chest 1996; 109: 62-6
Mikami R, Sekiguchi M, Ryuzin Y, et al. Changes in the peripheral vasculature of various organs in patients with sarcoidosis: possible role of microangiopathy. Heart Vessels 1986; 2: 129-39
Matsui Y, Iwai K, Tachibana T, et al. Clinicopathological study of fatal myocardial sarcoidosis. Ann NY Acad Sci 1976; 278: 455-69
Mayock RL, Bertrand P, Morrison CE. Manifestations of sarcoidosis. Am J Med 1963; 35: 67-89
Yazaki Y, Isobe M, Hiroe M, et al. Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol 2001; 88: 1006-10
Fleming HA, Bailey SM. The prognosis of sarcoid heart disease in the United Kingdom. Ann NY Acad Sci 1986; 465: 543-50
Vignaux O, Dhote R, Duboc D, et al. Clinical significance of myocardial magnetic resonance abnormalities in patients with sarcoidosis: a 1-year follow-up study. Chest 2002; 122: 1895-901
Shammas RL, Movahed A. Sarcoidosis of the heart. Clin Cardiol 1993; 16: 462-72
Tei C, Ling LH, Hodge DO, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function a study in normals and dilated cardiomyopathy. J Cardiol 1995; 26: 357-66
Poulsen SH, Jensen SE, Nielsen JC, et al. Serial changes and prognostic implications of a Doppler-derived index of combined left ventricular systolic and diastolic myocardial performance in acute myocardial infarction. Am J Cardiol 2000; 85: 19-25
Örem C, Küçükosmanoglu M, Hacihasanoglu A, et al. Association of Doppler-derived myocardial performance index with albuminuria in patients with diabetes. J Am Soc Echocardiogr 2004; 17: 1185-90
Yeo TC, Dujardin KS, Tei C, et al. Value of Doppler-derived index combining systolic and diastolic time intervals in predicting outcome in primary pulmonary hypertension. Am J Cardiol 1998; 81: 1157-61
Yilmaz R, Gencer M, Ceylan E, et al. Impact of chronic obstructive pulmonary disease with pulmonary hypertension on