Montelukast ile ilişkili Churg-Strauss sendromu

A young male with complaints of cough, dyspnea and hemoptysis was admitted. He was using fluticasone propionate and salmeterol for two years for his asthma. Leukotriene receptor antagonist was prescribed two weeks prior to his admission and no reduction of his inhaled steroid therapy was performed. Eosinophil count was detected as 1460/mm3 (15%) and immunoglobulin E level was 547 IU/mL. Thorax computerized tomography revealed patchy infiltration. Increased eosinophilic inflammation were detected in bronchoalveolar lavage fluid and transbronchial biopsy. He received prednisolone treatment for Churg-Strauss syndrome. Improvement was observed on three months follow up period. He has no complaint in his follow up.

Özet

Beş gündür öksürük, nefes darlığı ve kan tükürme yakınması başlayan erkek hasta iki yıldır astım bronşiyale tanısıyla flutikazon propionat ve salmeterol tedavisi kullanmaktaydı. İki hafta önce mevcut tedavisine inhaler steroid dozu azaltılmadan montelukast eklendiğini belirtti. Hastanın serum eozinofil sayısı 1460/mm3 (%15) ve immünglobulin E düzeyi 547 IU/mL idi. Toraks bilgisayarlı tomografisinde yamalı infiltrasyonlar saptanan hastanın bronkoalveoler lavaj sıvısında ve transbronşiyal biyopside eozinofilik inflamasyon tespit edildi. Churg-Strauss sendromu tanısıyla prednizolon tedavisi baş- lanan hastada üç aylık tedavi sonrasında tam yanıt elde edildi. Hasta halen flutikazon propionat ve salmeterol tedavisi altında sorunsuz izlenmektedir.

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Cite This Article

UYAR, M., BAKIR, K., ELBEK, O., BAYRAM, N., DİKENSOY, Ö., KİBAR, Y. (2022). Montelukast ile ilişkili Churg-Strauss sendromu. Tüberküloz ve Toraks, Cilt: 60 - Sayı: 1, 56–58. https://ajindex.com/articles/618699

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References (15)

Jamaleddine G, Diab K, Tabbarah Z, et al. Leukotriene antagonists and the Churg-Strauss syndrome. Semin Arthritis Rheum 2002; 31: 218-27
Michael AB, Murphy D. Montelukast-associated Churg-Strauss syndrome. Age Ageing 2003; 32: 551-2
Solans R, Bosch JA, Selva A, et al. Montelukast and ChurgStrauss syndrome. Thorax 2002; 57: 183-5
Boccagni C, Tesser F, Mittino D, et al. Churg-Strauss syndrome associated with the leukotriene antagonist montelukast. Neurol Sci 2004; 25: 21-2
Kalyoncu AF, Karakaya G, Sahin AA, Artvinli M. Experience of 10 years with Churg-Strauss syndrome: an accompaniment to or a transition from aspirin-induced asthma? Allergol Immunopathol (Madr) 2001; 5: 185-90
Weller PF, Plaut M, Taggart V, Trontell A. The relationship of asthma therapy and Churg-Strauss syndrome: NIH workshop summary report. J Allergy Clin Immunol 2001; 108: 175-83
Ozlen B, Ozdemir L, Eskitutuncu B, Cevirme L, Kurtar N, Soy M, et al. Churg-Strauss syndrome associated with montelukast. Tuberk Toraks 2008; 56: 434-8
Kaliterna DM, Perkovic D, Radic M. Churg-Strauss syndrome associated with montelukast therapy. J Asthma 2009; 46: 604-5
Mc Dannel DL, Muller BA. The linkage between Churg-Strauss syndrome and leukotriene receptor antagonists: Fact or fiction? Ther Clin Risk Manag 2005; 2: 125-40
Nathani N, Little MA, Kunst H, Wilson D, Thickett DR.ChurgStrauss syndrome and leukotriene antagonist use: a respiratory perspective. Thorax 2008; 63: 883-8
Katz RS, Papernik M. Zafirlukast and Churg-Strauss syndrome. JAMA 1998; 279: 1949-50
Tuggey JM, Hosker HS. Churg-Strauss syndrome associated with montelukast therapy. Thorax 2000; 55: 805-6
Soy M, Ozer H, Canataroglu A, Gumurdulu D, Erken E. Vasculitis induced by zafirlukast therapy. Clin Rheumatol 2002; 21: 328-9
Guilpain P, Viallard JF, Lagarde P, Cohen P, Kambouchner M, Pellegrin JL, et al. Churg-Strauss syndrome in two patients receiving montelukast. Rheumatology (Oxford) 2002; 41: 535-9
Lilly CM, Churg A, Lazarovich M, Pauwels R, Hendeles L, Rosenwasser LJ, et al. Asthma therapies and Churg-Strauss syndrome. J Allergy Clin Immunol 2002; 109: 1-19.