Journals / Tüberküloz ve Toraks / 2014 / Cilt: 62 - Sayı: 1

Treatment of severe asthma: Expert opinion

Ağır astım tedavisi: Uzman görüşü

Pages
51–67
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In th is paper takin g into account th e con ditions of our country,current literature was reviewed an d treatment options was discussed an d graded recommen dations are made for daily clinical practice in patients with severe treatment-refractory asthma.

📌 3 Key Takeaways

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Objective & Hypothesis:Severe asth matics account 10% of th e all asth matic po pulation.
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Key Findings & Data:New th erapeutic options were tried in th ose patients wh ose asth ma was uncontrolled with stan dart h igh dose in haledcorticosteroid and lon g actin gbeta-2 a gonsit combination therapy.
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Conclusion & Impact:In th is paper takin g into account th e con ditions of our country,current literature was reviewed an d treatment options was discussed an d graded recommen dations are made for daily clinical practice in patients with severe treatment-refractory asthma.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Severe asth matics account 10% of th e all asth matic po pulation. Th ose asth matics wh ose disease is inadequately controlled accoun tfor up to half of th e cost for asth ma, because th ey h ave more emer gency room visits, more h ospital admission an d greater absentee-ism from work. New th erapeutic options were tried in th ose patients wh ose asth ma was uncontrolled with stan dart h igh dose in haledcorticosteroid and lon g actin gbeta-2 a gonsit combination therapy. In th is paper takin g into account th e con ditions of our country,current literature was reviewed an d treatment options was discussed an d graded recommen dations are made for daily clinical practice in patients with severe treatment-refractory asthma.

Özet

Ağır astım tüm astımlı hasta popülasyonunun yakla ş ık %10'unuo lu şturur. Astım kontro lünün sorun o ldu ğu b u grup h asta larda acilservis b a şvuru ları, h astane yatışları, iş- güç kayıpları yü kse k oran larda görülür. Dolayısıyla tedavi maliyetleri çok yüksektir ve tümastım maliyetinin %50'si bu grup için h arcanmaktadır. Genellikle yüksek doz in h aler steroid ve uzun etkili beta-2 agonist kombinas-yonu ile kontrol altına alınamayan bu grup h astalarda farklı tedavi seçenekleri denenmektedir. Bu kısa raporda güncel literatür veri-leri derlenerek stan dart tedaviye dirençli a ğır astımlı h astalarda tedavi seçenekleri ülkemiz koşulları da göz önüne alınarak tartışılmışve gün lük klinik pratik için önerilerde bulunulmuştur.

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Cite This Article

POLATLI, M., BAVBEK, S., GEMİCİOĞLU, B., YILDIRIM, N., DEMİR, T., MUNGAN, D., KIYAN, E., ELİK, G., YILDIZ, F., SARYAL, S., YORGANCIOĞLU, A., ŞEN, E., GÜNEN, H., TÜRKTAŞ, H., OĞUZÜLGEN, İ. K., SAYINER, A. (2022). Treatment of severe asthma: Expert opinion. Tüberküloz ve Toraks, Cilt: 62 - Sayı: 1, 51–67. https://ajindex.com/articles/618618

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References (11)

  1. Sch ünemann HJ, Jaeschke R, Coo k DJ, Bria WF, El-So lh AA, Ernst A, et a l. An official ATS statement: grading th e quality of evidence an d stren gth of recommen dations in ATS guidelines an d recommen dations. Am J Respir Crit Care Med 2006;174(5):605-14
  2. Ch un g KF, Wenze l SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. Internationa l ERS/ATS guide lines on definition, eva luation an d treatment of severe asth ma. Eur Respir J 2014;43(2):343-73
  3. Ch un g KF. New treatments for severe treatment-resistan t asth ma: targetin g th e righ t patient. Lancet Respir Me d 201 3;1:84-90
  4. Virchow JC Jr, Prasse A, Na ya I, Summerton L, Harris A. Zafirlu k ast improves asth ma contro l in patients receivin g h igh -dose in h aled corticosteroids. Am J Respir Crit Care Me d 2000;162(2 Pt 1):578-85
  5. Ducharme FM, Lasserson TJ, Cates CJ. Lon g-acting beta2 - agonists versus antileu kotrienes as add-on th erapy to inhaled corticosteroids for chronic asthma. Cochrane Datab ase Sy st Rev 2006(4):CD003137
  6. Lemansk e RF Jr, Mau ger DT, Sorkness CA, Jac kson DJ, Boe h mer SJ, Martinez FD, et a l. Step-u p th erapy for ch il- dren wit h uncontro lled asth ma receivin g in ha le d corticos - teroids. N En gl J Med 2010;362(11):975-85
  7. Dahlén B, Nizan k owska E, Szcze klik A, Zetterström O, Bochenek G, Kumlin M, et al. Benefits from addin g the 5-lipoxygenase in h ib itor zileuton to conventional th erapy in aspirin-into lerant asth matics. Am J Respir Crit Care Med 1998;157(4 Pt 1 ):1187-94
  8. Da hlén SE, Malmström K, Nizan kows ka E, Dahlén B, Kuna P, Kowa ls ki M, et al. Im provement of as pirin-into leran t asth ma b y montelu kast, a leu k otriene antagonist: a ran d- omized, dou ble-blin d, placeb o-contro lled trial. Am J Respir Crit Care Med 2002;165(1):9-14
  9. Evans DJ, Taylor DA, Zetterstrom O, Ch ung KF, O'Connor BJ, Barnes PJ. A com parison of low-dose in h a le d b u deso- n ide plus th eoph y lline an d h igh -dose in h aled b udesonide for mo derate asth ma. N Engl J Med 1997;337(20):1412-8
  10. Ukena D, Harnest U, Sakalauskas R, Ma gyar P, Vetter N, Steffen H, et al. Com parison of addition of theo ph y lline to in h ale d steroid with dou blin g of th e dose of in h aled steroid in asth ma. Eur Respir J 1997;10(12):2754-60
  11. Spears M, Donnelly I, Jo lly L, Brannigan M, Ito K, McSh arry C, et al. Effect of low-dose th eo phylline plus b ec lometa - sone on lun g function in smo k ers with asth ma: a pilo t stu dy. E