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Journals / Tüberküloz ve Toraks / 2016 / Cilt: 64 - Sayı: 3

Sepsis nedeniyle yoğun bakıma alınan hastalarda adrenal yetmezlik varlığında adrenomedullin mortalite ilişkisi

Level of adrenomedullin in cases with adrenal defficiency and its relation to mortality in patients with sepsis

Baran BALCAN
Türkay AKBAŞ
Emel ERYÜKSEL
Sait KARAKURT
Şehnaz OLGUN
Pages
191–197
Publication Date
2022-11-05
DOI
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Conclusion: Without evaluation of adrenal function adrenomedullin should not be used, in predicting mortality of sepsis.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: The aim of this study was to determine the prognostic value of adrenomedullin, after evaluation of adrenal function in sepsis patients.
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Key Findings & Data:We enrolled 48 patients, who were admitted to the intensive care unit due to sepsis according to surviving sepsis campaign criteria.
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Conclusion & Impact:Conclusion: Without evaluation of adrenal function adrenomedullin should not be used, in predicting mortality of sepsis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: The aim of this study was to determine the prognostic value of adrenomedullin, after evaluation of adrenal function in sepsis patients. We also evaluated other prognostic factors such as APACHE II score, proBNP, and CRP and their prediction in mortality. Materials and Methods: This is a prospective, observational study. We enrolled 48 patients, who were admitted to the intensive care unit due to sepsis according to surviving sepsis campaign criteria. Results: ADM median value was 60.8 ng/L in patients with normal adrenal function, and 20.1 ng/L in patients who had adrenal deficiency. With adequate adrenal response there was a linear and statistically significant relationship between adrenomedullin and mortality (p 30.19 ng/L (sensitivity: 73.0%, specificity: 100%), APACHE II score was > 21 (sensitivity: 93.3%, specificity: 84.8%), and proBNP > 3736 pg/mL (sensitivity: 73.3%, specificity: 93.9%). Conclusion: Without evaluation of adrenal function adrenomedullin should not be used, in predicting mortality of sepsis.

Özet

Giriş: Bu çalışmanın amacı, sepsis hastalarında adrenal fonksiyonu değerlendirdikten sonra adrenomedullin ile mortalite arasında ilişki kurmaktır. Bunun yanında APACHE II skoru, proBNP ve C-reaktif protein (CRP) gibi diğer markerlar ile mortalite arasındaki ilişki değerlendirilmiştir.Bulgular: Median adrenomedüllin (ADM) değeri adrenal yanıtı tam olan hastalarda 60.8 ng/L olarak bulunmuş, adrenal yetmezlikli hastalarda 20.1 ng/L olarak tespit edilmiştir. Yeterli adrenal yanıtın olduğu hastalarda adrenomedullin ile mortalite arasında doğrusal ve anlamlı bir ilişki tespit edilmiştir (p 30.19 ng/L, APACHE II skoru > 21 ve proBNP > 3736 pg/mL olan hastalarda mortalitenin anlamlı ölçüde yüksek olduğu tespit edilmiştir.Sonuç: Hastalarda mortalite ve adrenomedullin arasında ilişki kurmadan önce adrenal fonksiyonun yeterli olup olmadığı değerlendirilmelidir

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Cite This Article

BALCAN, B., AKBAŞ, T., ERYÜKSEL, E., KARAKURT, S., OLGUN, Ş. (2022). Sepsis nedeniyle yoğun bakıma alınan hastalarda adrenal yetmezlik varlığında adrenomedullin mortalite ilişkisi. Tüberküloz ve Toraks, Cilt: 64 - Sayı: 3, 191–197. https://ajindex.com/articles/618528

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