SavedAdd your journal

Journals / Tüberküloz ve Toraks / 2018 / Cilt: 66 - Sayı: 2

The role of endobronchial and endoscopic ultrasound guided fine needle aspiration for mediastinal nodal staging of non-small-cell lung cancer

Küçük hücreli dışı akciğer kanserinde endobronşiyal ve endoskopik ultrason rehberliğinde ince iğne aspirasyonunun mediastinal nodal evrelemedeki rolü

Işın GÜNEŞ
Ömer ÖNAL
Nuri TUTAR
İnci GÜLMEZ
Şebnem GÜRSOY
Alper YURCİ
Özlem CANÖZ
Pages
85–92
Publication Date
2022-11-04
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thesensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography with computed tomography (PET-CT),EBUS-TBNA, EUS-FNA and combined EBUS-TBNA and EUS-FNA were 100%, 33.3%, 64.7%, 100% and 70.0%; 81.8%, 100%,100%, 81.8% and 90%; 81.8%, 100%, 100%, 75% and 88.2%; 90.9%, 100%, 100%, 90.0% and 95.0%, respectively.Conclusion: The combined EBUS-TBNA and EUS-FNA technique is a successful procedure for nodal staging in potentially operableNSCLC patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Mediastinal and hilar nodal staging is one of the key points for differentiating treatment modalities in patients with nonsmall-cell lung cancer (NSCLC).
📊
Key Findings & Data:The aim of the present study was to determinate the diagnostic yields of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) andcombined EBUS-TBNA and EUS-FNA modalities for nodal staging in potentially operable NSCLC patients.Materials and Methods: Twenty consecutive patients were prospectively enrolled in the study between March 2014 andNovember 2015.
💡
Conclusion & Impact:Thesensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography with computed tomography (PET-CT),EBUS-TBNA, EUS-FNA and combined EBUS-TBNA and EUS-FNA were 100%, 33.3%, 64.7%, 100% and 70.0%; 81.8%, 100%,100%, 81.8% and 90%; 81.8%, 100%, 100%, 75% and 88.2%; 90.9%, 100%, 100%, 90.0% and 95.0%, respectively.Conclusion: The combined EBUS-TBNA and EUS-FNA technique is a successful procedure for nodal staging in potentially operableNSCLC patients.
🔬Design:Research Article
📍Scope:2014 Verileri
⚙️Variables:Domain Parameters

Abstract

Introduction: Mediastinal and hilar nodal staging is one of the key points for differentiating treatment modalities in patients with nonsmall-cell lung cancer (NSCLC). The aim of the present study was to determinate the diagnostic yields of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) andcombined EBUS-TBNA and EUS-FNA modalities for nodal staging in potentially operable NSCLC patients.Materials and Methods: Twenty consecutive patients were prospectively enrolled in the study between March 2014 andNovember 2015. All patients had a potentially operable NSCLCdiagnosis before endosonographic procedures.Results: Thirty lymph nodes were sampled by EBUS-TBNA and 17lymph nodes were sampled by EUS-FNA in all 20 patients. Thesensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography with computed tomography (PET-CT),EBUS-TBNA, EUS-FNA and combined EBUS-TBNA and EUS-FNA were 100%, 33.3%, 64.7%, 100% and 70.0%; 81.8%, 100%,100%, 81.8% and 90%; 81.8%, 100%, 100%, 75% and 88.2%; 90.9%, 100%, 100%, 90.0% and 95.0%, respectively.Conclusion: The combined EBUS-TBNA and EUS-FNA technique is a successful procedure for nodal staging in potentially operableNSCLC patients.

Özet

Giriş: Küçük hücreli dışı akciğer kanseri (KHDAK) hastalarında değişik tedavi modalitelerini değerlendirmek için anahtar noktalardan birisi mediastinal ve hiler nodal evrelemedir. Bu çalışmanın amacı endobronşiyal ultrason rehberliğinde transbronşiyal iğne aspirasyonu (EBUS-TBİA), endoskopik ultrason rehberliğinde ince iğne aspirasyonu (EUS-İİA) ve kombine EBUS-TBİA ile EUS-İİA’nın potansiyel olarak ameliyat edilebilecek hastalarda nodal evrelemedeki tanı başarısını saptamaktır. Materyal ve Metod: Mart 2014 ve Kasım 2015 tarihleri arasında ardı ardına 20 hasta çalışmaya dahil edildi. Tüm hastalar endosonografik işlemler öncesi potansiyel olarak ameliyat olabilecek KHDAK tanısı almıştı. Bulgular: Yirmi hastada EBUS-TBİA ile 30 lenf nodu, EUS-İİA ile 17 lenf nodu örneklendi. F-18 florodeoksiglukoz pozitron emisyon tomografi-bilgisayarlı tomografi (PET-BT), EBUS-TBİA, EUS-İİA ve kombine EBUS-TBİA ile EUS-İİA’nın sensitivite, spesifite, pozitif tahmini değer, negatif tahmini değer ve tanı başarısı sırasıyla %100, %33.3, %64.7, %100 ve %70.0; %81.8, %100, %100, %81.8 ve %90; %81.8, %100, %100, %75 ve %88.2; %90.9, %100, %100, %90.0 ve %95.0’dı. Sonuç: Kombine EBUS-TBİA ile EUS-İİA tekniği potansiyel olarak ameliyat olabilecek KHDAK hastalarının nodal evrelemesinde başarılı bir yöntemdir.

🔖

Cite This Article

GÜNEŞ, I., ÖNAL, Ö., TUTAR, N., GÜLMEZ, İ., GÜRSOY, Ş., YURCİ, A., CANÖZ, Ö. (2022). The role of endobronchial and endoscopic ultrasound guided fine needle aspiration for mediastinal nodal staging of non-small-cell lung cancer. Tüberküloz ve Toraks, Cilt: 66 - Sayı: 2, 85–92. https://ajindex.com/articles/618468

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (7)

  1. Silvestri GA, Gonzalez AV, Jantz MA, Margolis ML, Gould MK, Tanoue LT, et al. Methods for staging non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013;143(5 Suppl):e211S-50S. Harders SW, Madsen HH, Hjorthaug K, Arveschoug AK, Rasmussen TR, Meldgaard P, et al. Mediastinal staging in Non-Small-Cell Lung Carcinoma: computed tomography versus F-18-fluorodeoxyglucose positron-emission tomography and computed tomography. Cancer Imaging 2014;14:23. Toloza EM, Harpole L, McCrory DC. Non-inva sive staging of non-small cell lung cancer: a review of the current evidence. Chest 2003;123:137S-46S. De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, RamiPorta R, et al. Preoperative mediastinal lymph node staging for nonsmall cell lung cancer: 2014 update of the 2007 ESTS guidelines. Transl Lung Cancer Res 2014;3:225-33.
  2. Herth FJ, Krasnik M, Kahn N, Eberhardt R, Ernst A. Combined endoscopic-endobronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes through a single bronchoscope in 150 patients with suspected lung cancer. Chest 2010;138:790-4. Annema JT, van Meerbeeck JP, Rintoul RC, Dooms C, Deschepper E, Dekkers OM, et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: arandomized trial. JAMA 2010;304:2245-52.
  3. Berania I, Kazakov J, Khereba M, Goudie E, Ferraro P, Thiffault V, et al. Endoscopic Mediastinal Staging in Lung Cancer is Superior to “Gold Standard” Surgical Staging. Ann Thorac Surg 2016;101:547-50.
  4. Zhang R, Ying K, Shi L, Zhang L, Zhou L. Combined endobronchial and endoscopic ultrasoundguided fine needle aspiration formediastinal lymph node staging of lung cancer: a meta-analysis. Eur J Cancer 2013;49:1860-7. Mountain CF. Revisions in the International System for Staging Lung Cancer. Chest 1997;111:1710-7.
  5. Dhooria S, Aggarwal AN, Gupta D, Behera D, Agarwal R. Utility and Safety of Endoscopic Ultrasound With Bronchoscope-Guided Fine-Needle Aspiration in Mediastinal Lymph Node Sampling: Systematic Review and Meta-Analysis. Respir Care 2015;60:1040-50.
  6. Colella S, Vilmann P, Konge L, Clementsen PF. Endoscopic ultrasound in the diagnosis and staging of lung cancer. Endosc Ultrasound 2014;3:205-212.
  7. Ozgül MA, Cetinkaya E, Tutar N, Ozgül G, Onaran H, Bilaceroglu S. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrathoracic lymphadenopathy in patients wi