Journals / Tüberküloz ve Toraks / 2018 / Cilt: 66 - Sayı: 2

The role of F-18 FDG PET/CT in differentiating benign from malignant pulmonary masses and accompanying lymph nodes

Akciğer kitleleri ve eşlik eden lenf nodlarının benign/malign ayırımında F-18 FDG PET/BT’nin rolü

Pages
130–135
Publication Date
2022-11-05
DOI
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The sensitivity was 87% and specificity was 45% for the lesion sizes indifferentiation of the malignant and benign lesions.Conclusion: There are significant overlaps between benign and malignant lesions and specialists must be aware of the various pathological conditions that can give false positives and negatives.

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Objective & Hypothesis:The role of F-18 FDG PET/CT in differentiating benign from malignant pulmonary masses and accompanying lymph nodesIntroduction: The aim of this study was to evaluate the usefulness of SUVmax and lesion size to differentiate benign and malignantlesions of the lung and accompanying mediastinal lymph node on F-18 FDG PET/CT imaging.Materials and Methods: A retrospective analysis was carried out on 100 patients with suspected lung cancer who were recommendedfor PET/CT scans for diagnosis and staging.
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Key Findings & Data:Lymphnodes greater than 1 cm in patients with benign pathology wereevaluated and the SUVmax values were recorded.Results: Of the 100 patients, 38 were found to have benign, whereas 62 had malignant on histopathology.
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Conclusion & Impact:The sensitivity was 87% and specificity was 45% for the lesion sizes indifferentiation of the malignant and benign lesions.Conclusion: There are significant overlaps between benign and malignant lesions and specialists must be aware of the various pathological conditions that can give false positives and negatives.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The role of F-18 FDG PET/CT in differentiating benign from malignant pulmonary masses and accompanying lymph nodesIntroduction: The aim of this study was to evaluate the usefulness of SUVmax and lesion size to differentiate benign and malignantlesions of the lung and accompanying mediastinal lymph node on F-18 FDG PET/CT imaging.Materials and Methods: A retrospective analysis was carried out on 100 patients with suspected lung cancer who were recommendedfor PET/CT scans for diagnosis and staging. The results of theSUVmax, lesion size and patient’s age were compared withhistopathology which was considered to be the ’gold standard’ andsensitivity and specificity were calculated respectively. Lymphnodes greater than 1 cm in patients with benign pathology wereevaluated and the SUVmax values were recorded.Results: Of the 100 patients, 38 were found to have benign, whereas 62 had malignant on histopathology. The SUVmax was significantly more elevated in malign masses (13.1 ± 6.4) than in benign masses (8 ± 5.7) (p< 0.05). The dimensions of malignant masses(4.5 ± 2.5 cm) were larger than benign ones (3 ± 1.6 cm) (p< 0.05). SUVmax of 7.6 was determined as the cut-off value, while thesensitivity and specificity were 82% and 55% respectively. The sensitivity was 87% and specificity was 45% for the lesion sizes indifferentiation of the malignant and benign lesions.Conclusion: There are significant overlaps between benign and malignant lesions and specialists must be aware of the various pathological conditions that can give false positives and negatives.

Özet

Giriş: Bu çalışmada, akciğerde kitle ve eşlik eden mediastinal lenf nodu saptanan hastalarda F-18 FDG pozitron emisyon tomografi/ bilgisayarlı tomografi (PET/BT) görüntülemesinde elde edilen SUVmax değerinin ve lezyon çapının benign ve malign kitleleri ayırt etmedeki rolünü belirlemek amaçlanmıştır. Materyal ve Metod: Akciğerde kitle nedeniyle tanı ve evreleme amaçlı PET/BT yapılan ve biyopsi veya kitle rezeksiyonu ile histopatolojik sonuçlarına ulaşılan 100 hasta çalışmaya dahil edildi. SUVmax değerleri, lezyon boyutu ve hasta yaşı, altın standart kabul edilen histopatolojik sonuçlar ile karşılaştırılarak duyarlılık ve özgüllük değerleri hesaplandı. Benign patolojilere eşlik eden 1 cm’den büyük lenf nodları değerlendirilerek SUVmax ölçümleri kaydedildi. Bulgular: Histopatolojik olarak 62 lezyon malign, 38 lezyon benign olarak saptandı. Malign kitlelerdeki SUVmax değerleri (13.1 ± 6.4) benign kitlelerin SUVmax değerinden (8 ± 5.7) istatistiksel anlamlı olarak yüksek idi (p< 0.05). Malign kitlelerde boyut (4.5 ± 2.5 cm ), benign kitlelerden (3 ± 1.6 cm) istatistiksel anlamlı olarak artmış saptandı (p< 0.05). Malign ve benign kitleleri ayırt etmede lezyon SUVmax değeri için sensitivite %82, spesifisite %55, lezyon boyutu için sensitivite %87, spesifisite %45 olarak saptandı. Sonuç: Malign ve benign akciğer kitlelerinin değerlendirilmesinde önemli düzeyde birbiri ile çakışan değerler olabilmektedir. Uzmanlar değerlendirmelerinde yanlış pozitif ve yanlış negatif sonuçları göz önünde bulundurmalıdır.

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Cite This Article

DERTSİZ, L., CENGİZ, A., BOZ, A., AYDIN, F., GÜNGÖR, F., ERKILIÇ, M., ÖZBİLİM, G., SİPAHİ, M., BOZKURT, S. (2022). The role of F-18 FDG PET/CT in differentiating benign from malignant pulmonary masses and accompanying lymph nodes. Tüberküloz ve Toraks, Cilt: 66 - Sayı: 2, 130–135. https://ajindex.com/articles/618454

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