Journals / Tüberküloz ve Toraks / 2019 / Cilt: 67 - Sayı: 2

Value of cardiopulmonary exercise testing in the diagnosis of coronary artery disease

Kardiyopulmoner egzersiz testlerinin koroner arter hastalığındaki tanısal değeri

Pages
102–107
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion parameters obtained during the test that are not influenced by patient’s effort mightincrease the value of CPET in the diagnosis CAD.

📌 3 Key Takeaways

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Objective & Hypothesis:Introduction: Respiratory and cardiac functions in association with skeletaland neurophysiologic systems can be evaluated with cardiopulmonaryexercise testing (CPET).
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Key Findings & Data:Oxygen consumption (VO2), carbondioxide production(VCO2), minute ventilation (VE), maximum work rate (WR), DVO2/DWR andO2 pulse (VO2/HR) values were calculated.
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Conclusion & Impact:In conclusion parameters obtained during the test that are not influenced by patient’s effort mightincrease the value of CPET in the diagnosis CAD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Introduction: Respiratory and cardiac functions in association with skeletaland neurophysiologic systems can be evaluated with cardiopulmonaryexercise testing (CPET). Compared to treadmill exercise test, CPET providesmore comprehensive data about the hemodynamic response to exercise.Materials and Methods: We aimed to evaluate the relationship with CPETfindings and coronary lesions identified on angiography in patients withangina pectoris who underwent teradmill exercise, CPET and coronaryangiography (CAG). By this way we sought to examine the CPET parametersthat might be predictive for coronary artery disease (CAD) before diagnosticexercise test results and ischemia symptoms develop. Thirty patients in whomCAG was planned because of symptoms and exercise test results wereenrolled in the study. Oxygen consumption (VO2), carbondioxide production(VCO2), minute ventilation (VE), maximum work rate (WR), DVO2/DWR andO2 pulse (VO2/HR) values were calculated. Significant CAD was defined as≥ 50% narrowing in at least one of the coronary arteries.Results: The mean age was 60.4 ± 8.9 years ve 21 (65.6%) of subjects weremale. On CAG, CAD was detected in 19 (59.4%) patients. Maximum heartrate, heart rate reserve (HRR), VE/VCO2 measured at anaerobic threshold(AT) and VO2(mL/kg/min) were significantly differed in patients with CAD than those without (p= 0.031; p= 0.041; p= 0.028; p=0.03 respectively). Peak VO2, VO2/WR and O2 pulse values were higher in patients with normal angiographic results than those withCAD but the difference did not reach to statistical significance.Conclusion: The findings of our study indicate that among CPET parameters AT VE/VCO2, ATVO2 (mL/kg/dk) and HRR can havepredictive value in the diagnosis of CAD. We think that these parameters might be used in the evaluation of patients with angina anddyspnea suspected of CAD. In conclusion parameters obtained during the test that are not influenced by patient’s effort mightincrease the value of CPET in the diagnosis CAD.

Özet

Giriş: Kardiyopulmoner egzersiz testi (KPET) solunumsal ve kardiyak işlevlerle birlikte kas-iskelet sistemi ve nörofizyolojik sistemlerin değerlendirilmesini sağlayan bir yöntemdir. KPET egzersize hemodinamik yanıtı klasik efor testine kıyasla detaylı olarak değerlendirmemizi sağlar. Materyal ve Metod: Çalışmamızda göğüs ağrısı tanımlayan, efor testi yapılan ve koroner anjiyografi (KAG) planlanan hastalara KPET yapılarak, KPET bulguları ile KAG’da saptanan lezyon yaygınlığı arasındaki ilişkiyi araştırdık. Böylece efor testinde tanısal EKG bulguları ve iskemiyle ilişkili semptomlar gelişmesini beklemeden, KPET ile koroner arter hastalığı (KAH) için tanısal olan parametreleri belirlemeyi amaçladık. Çalışmamıza semptomları ve efor testi sonuçları ile KAG planlanan 30 hasta dahil edildi. Oksijen kullanımı (VO2), karbondioksit üretimi (VCO2), dakika ventilasyonu (VE), maksimum ulaşılan iş yükü (WR), DVO2/DWR ve O2 pulse (VO2/HR) değerleri hesaplandı. Koroner arterlerden herhangi birinde ≥ %50 darlığın saptanması anlamlı koroner arter hastalığı kabul edildi. Bulgular: Hastaların ortalama yaşı 60.4 ± 8.9 yıl ve 21 (%65.6)’i erkekti. Koroner anjiyografi ile 19 (%59.4) hastada koroner arterlerde stenoz saptandı. KAH saptanan grupta maksimum kalp hızı, kalp hızı rezervi (HRR), anaeorobik eşik (AT)'te ölçülen VE/VCO2 ve VO2 (mL/kg/dk) KAH saptanmayan gruba göre anlamlı farklıydı (p 0.05). Sonuç: Çalışmamız sonucunda AT, VE/VCO2, ATVO2 (mL/kg/dk), maksimum HR ve HRR’nin KAH tanısını destekleyen önemli parametreler olduğu saptandı. Bu nedenle dispne ve göğüs ağrısı etiyolojisine yönelik değerlendirilen hastalarda bu parametrelerin KAH için tanısal olabileceği düşüncesindeyiz. Sonuç olarak hasta eforundan etkilenmeyen ve tetkik sırasında görüntülenebilen parametreler KPET’in KAH tanısında kullanımını artıracaktır.

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Cite This Article

ULUBAY, G., AYDINALP, A., BOZBAŞ, Ş. S., ÖZYÜREK, B. A., BOZBAŞ, H. (2022). Value of cardiopulmonary exercise testing in the diagnosis of coronary artery disease. Tüberküloz ve Toraks, Cilt: 67 - Sayı: 2, 102–107. https://ajindex.com/articles/618406

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