Journals / Turkish Respiratory Journal / 2002 / Cilt: 3 - Sayı: 2

Hyperimmunoglobulin E (Job's) syndrome: A rare cause of recurrent pneumatocele, lung abscess and empyema in childhood

Pages
68–71
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This article describes a case of HIE (Job's) syndrome as a cause of recurrent lung infections with abscess, pneumatocele formation and empyema necessitating tube thoracostomy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The hyperimmunoglobulin E (HIE) or Job's syndrome is a rare and complex disorder characterized by recurrent staphylococcal lung infections with abscess and pneumatocele formation and chronic eczematoid dermatitis in childhood.
📊
Key Findings & Data:Laboratory evaluation reveals consistent elevation of circulating immunoglobulin E levels.
💡
Conclusion & Impact:This article describes a case of HIE (Job's) syndrome as a cause of recurrent lung infections with abscess, pneumatocele formation and empyema necessitating tube thoracostomy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The hyperimmunoglobulin E (HIE) or Job's syndrome is a rare and complex disorder characterized by recurrent staphylococcal lung infections with abscess and pneumatocele formation and chronic eczematoid dermatitis in childhood. Laboratory evaluation reveals consistent elevation of circulating immunoglobulin E levels. This article describes a case of HIE (Job's) syndrome as a cause of recurrent lung infections with abscess, pneumatocele formation and empyema necessitating tube thoracostomy.

🔖

Cite This Article

EREN, Ş., ÜLKÜ, R., BOŞNAK, M., EREN, M. N., BALCI, A. E. (2022). Hyperimmunoglobulin E (Job's) syndrome: A rare cause of recurrent pneumatocele, lung abscess and empyema in childhood. Turkish Respiratory Journal, Cilt: 3 - Sayı: 2, 68–71. https://ajindex.com/articles/617110

References (3)

  1. Davis SD, Schaller J, Wedgwood RJ. Job's syndrome recurrent "cold" staphylococcal abscesses. Lancet 1966;l:1013-1015
  2. Buckley RH, Wray BB, Belmaker EZ. Extreme hyperimmunoglob- ulinemia E and undue susceptibility to infection. Pediatrics 1972;49:59-70
  3. Hill HR, Quie PG. Raised serum-Ig E levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet 1974; 1:183-197 4. Jhaveri KS, SahaniDV, Shetty PG. Hyperimmunoglobulinaemia E syndrome: Pulmonary imaging features. Australasin Radiology 2000;44:328-330 5. Borges WG, Hensley T, Carey JC et al. The face of Job.The Journal of Pediatrics 1998;133:3O3-3O5 6. Donabedian H, Gallin JI. The hyperimmunoglobulin E recurrent- infection (Job's) syndrome: a review of the NIH experience and the litarature. Medicine 1983;62:195-208 7. Grimbacher B, Holland SM, Gallin JI, et al. Hyper-IgE syndrome with recurrent infections-an autosomal dominant multisystem disorder. The New England Journal of Medicine 1999;340:692-702 8. Lui RC, Inculet RI. Job's syndrome: A rare cause of recurrent lung abscess in childhood. Ann Thorac Surg 1990;50:992-994 9. Kirchner SG, Sivit CJ, Wright PF. Hyperimmunoglobulinemia E syndrome: association with osteoporosis and recurrent fractures. Radiology 1985;156:362 10. Ballard RW, Cummigs CW. Job's syndrome. The Lryngoscope 1980;90:1367-1370 11. Mawhinney H, Killen M, Fleming WA, et al. The hyperimmunoglobulin E syndrome-A neutrophil chemotactic defect reversible by histamine H2 receptor blockade? Clinical Immunology and Immunopathology 1980; 17:483-491 12. Swim AT, Bradac C, Craddock PR. Levamisole in Job's syndrome. The New England Journal of Medicine 1982;307:1528-1529 13. Donabedian H, Gallin JI. Mononuclear cells from patients with the hyperimmunoglobulin E-reccurrent-infections syndrome produce an inhibitor of leukocyte chemotaxis. J Clin Invest 1982;69:1155- 1163 14. Merten DF, Buckley RH, Pratt PC, et al. Hyperimmunoglobulinemia E syndrome: Radiographic observations. Radiology 1979; 132:71-78 15. Brestel EP, Klinberg WG, Veltri RW, et al. Osteogenesis Imperfecta Tarda in a child with hyper-IgE syndrome. Am J Dis Child 1982; 136:774-776 16. Leung DM, Geha RS. Clinical and immunologic aspects of the hyperimmunoglobulin E syndrome. Hematology/Oncology Clinics of North America 1988;2:81-100 17. Jacobs DH, Macher AM, Handler R, et al. Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E- recurrent infection (Job's) syndr