Journals / Turkish Neurosurgery / 2012 / Cilt: 22 - Sayı: 4

Anevrizmal subaraknoid kanamaya bağlı vazospazmın tedavisinde hemodinamik destek

Haemodynamic augmentation in the treatment of vasospasm in aneurysmal subarachnoid hemorrhage

Pages
435–440
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Induced hypertension establishes the haemodynamic augmentation to prevent and treat vasospasm.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:AIM: Hypertension, hypervolemia and hemodilution therapy is a common approach to cerebral vasospasm after subarachnoid haemorrhage.
📊
Key Findings & Data:This study is designed to see the difference of moderate or aggressive hypervolemia supported with induced hypertension in symptomatic vasospasm detected with transcranial Doppler ultrasonography (TCD) measurements.
💡
Conclusion & Impact:Induced hypertension establishes the haemodynamic augmentation to prevent and treat vasospasm.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: Hypertension, hypervolemia and hemodilution therapy is a common approach to cerebral vasospasm after subarachnoid haemorrhage. This study is designed to see the difference of moderate or aggressive hypervolemia supported with induced hypertension in symptomatic vasospasm detected with transcranial Doppler ultrasonography (TCD) measurements. MaterIal and Methods: Fifty eight patients who had aneurysm clipping and were admitted to the neurointensive care unit were treated with normovolemia and induced hypertension (n=35) or hypervolemia supported with induced hypertension (n=23) targeting a mean arterial pressure of 110-130 mm Hg and central venous pressure of 8-12 mm Hg. Daily TCD, fluid intake, fluid balance and haemodynamic values were recorded for 14 days. Results: There were no differences detected in mean arterial pressure, central venous pressure, hematocrit values, fluid balance and middle cerebral artery flow velocities between the two groups through 14 days (p>0.05). Hyponatremia, pulmonary edema and cerebral ischemia were observed as complications. ConclusIon: Hypervolemia adds no benefit compared to normovolemia in the treatment of vasospasm occurred as a result of subarachnoid hemorrhage. Induced hypertension establishes the haemodynamic augmentation to prevent and treat vasospasm.

Özet

AMAÇ: Subaraknoid kanamaya bağlı gelişen vasospasm tedavisinde hipertansiyon, hipervolemi ve hemodilüsyon tedavisi yaygın bir yaklaşımdır. Bu çalışma, transkranyal Doppler ultrasonografi ölçümleri ile saptanan semptomatik vasospasm durumlarında hipertansiyon ile desteklenen hafif veya agresif hipervoleminin farkını görmek için düzenlenmiştir. YÖNTEM ve GEREÇLER: Anevrizmaları kliplenen ve nöroyoğun bakım ünitesinde takip edilen 58 hastaya normovolemi ve hipertansiyon (n=35) ve hipervolemi ve hipertansiyon (n=23) uygulanarak 110-130 mmHg ortalama arter basıncı, 8-12 mmHg santral venöz basınç hedeflendi. TCD, sıvı alımı ve hemodinamik değerler kaydedildi. BULGULAR: On dört gün boyunca takip edilen ortalama arter basıncı, santral venöz basınç, hematokrit değerleri, sıvı dengesi ve orta serebral arter akım hızlarında iki grup arasında fark yoktu. Komplikasyon olarak hiponatremi, pulmoner ödem ve serebral iskemi kaydedildi. SONUÇ: Subaraknoid kanama sonucu ortaya çıkan vasospasmın tedavisinde normovolemi ile karşılaştırıldığında hipervolemi ek bir yarar sunmamaktadır. Hipertansiyon vasospasmı önlemek ve tedavi etmek için gereken hemodinamik desteği sağlamaktadır.

🔖

Cite This Article

ELMACI, I., SAGIROGLU, E., CERCI, A., GURA, M., COSKUN, K. K. (2022). Anevrizmal subaraknoid kanamaya bağlı vazospazmın tedavisinde hemodinamik destek. Turkish Neurosurgery, Cilt: 22 - Sayı: 4, 435–440. https://ajindex.com/articles/617015

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Bederson JB, Connolly ES Jr, Batjer HH, Dacey RG, Dion JE, Diringer MN, Duldner JE Jr, Harbaugh RE, Patel AB, Rosenwasser RH: American Heart Association: Guidelines for the management of aneurysmal subarachnoid hemorrhage: A statement for healthcare professionals from a special writing group of the stroke council, Stroke 40:994-1025, 2009 2. Dankbaar JW, Slooter AJ, Rinkel GJ, Schaaf IC: Effect of different component of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid hemorrhage: A systematic review. Crit Care 14:R23, 2010 3. Diringer MN: Management of aneurysmal subarachnoid hemorrhage. Crit Care Med 37:432-440, 2009 4. Egge A, Waterloo K, Sjøholm H, Solberg T, Ingebrigtsen T, Romner B: Prophylactic hyperdynamic postoperative fluid therapy after aneurysmal subarachnoid hemorrhage: A clinical, prospective, randomized, controlled study. Neurosurgery 49:593-606, 2001 5. Ekelund A, Saveland H, Romner B, Brandt L: Trancranial doppler ultrasound in hypertensive versus normotensive patients after aneurysmal subarachnoid hemorrhage. Stroke 26:2071-2074, 1995 6. Fisher C, Kistler J, Davis J: Relation of cerebral vasospasm to subarchnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6:1-9, 1980 7. Gupta D, Sharma BS, Gupta SK, Bapuraj R, Khosla VK: Postoperative hypertensive-hypervolaemic-haemodilution (triple H) therapy in the treatment of vasospasm following aneurysmal subarachnoid haemorrhage. Neurol India 48: 126-131, 2000 8. Harrod CG, Bendok BR, Batjer HH: Prediction of cerebral vasospasm in patients presenting with aneurysmal subarachnoid hemorrhage: A review. Neurosurgery 56: 633-654, 2005 9. Hunt WE, Hess RM: Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 28:14-20, 1968 10. Janjua N, Mayer SA: Cerebral vasospasm after subarachnoid haemorrhage. Curr Opin Crit Care 9:113-119, 2003 11. Jennett B, Bond M: Assessment of outcome after severe brain damage. Lancet 1: 480-484, 1975 12. Keyrouz SG, Diringer MN: Clinical review: Prevention and therapy of vasospasm in subarachnoid haemorrhage. Crit Care 11:220, 2007 13. Lee KH, Lukovits T, Friedman JA: ‘Triple–H’ Therapy for cerebral vasospasm following subarachnoid hemorrhage. Neurocrit Care 4:68-76, 2006 14. Lennihan L, Mayer SA, Fink ME, Beckford A, Paik MC, Zhang H, Wu YC, Klebanoff LM, Raps EC, Solomon RA: Effect of hypervolemic therapy on cerebral blood flow after subarachnoid hemorrhage. Stroke 31