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Journals / Turkish Neurosurgery / 2013 / Cilt: 23 - Sayı: 5

Rat Travmatik Siyatik Sinir Modelinde Lokal ve Sistemik Deksametazonun Etkisinin Araştırılması

Comparison of the Effects of local and Systemic Dexamethasone on the Rat Traumatic Sciatic nerve Model

Husnu SUSLU
Basar ERDIVANLI
Hikmet Turan SUSLU
Murat ALTUN
Pages
623–629
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The sciatic nerves of 32 rats were exposed at midthigh level and those of 24rats were crushed for 30 seconds with a pair of jeweler s forceps.Results: Sciatic functional index (SFI) measurements of all the animals included at days 7, 14, 21 and 28 was statistically significant (p

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: The aim of the study was to evaluate the effect of peroperatively locally administered dexamethasone on nerve recovery after inducednerve crush injury.MATERIAL and METHODS: 4 groups of 8 animals were formed.
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Key Findings & Data:AIM: The aim of the study was to evaluate the effect of peroperatively locally administered dexamethasone on nerve recovery after inducednerve crush injury.MATERIAL and METHODS: 4 groups of 8 animals were formed.
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Conclusion & Impact:The sciatic nerves of 32 rats were exposed at midthigh level and those of 24rats were crushed for 30 seconds with a pair of jeweler s forceps.Results: Sciatic functional index (SFI) measurements of all the animals included at days 7, 14, 21 and 28 was statistically significant (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: The aim of the study was to evaluate the effect of peroperatively locally administered dexamethasone on nerve recovery after inducednerve crush injury.MATERIAL and METHODS: 4 groups of 8 animals were formed. The sciatic nerves of 32 rats were exposed at midthigh level and those of 24rats were crushed for 30 seconds with a pair of jeweler s forceps.Results: Sciatic functional index (SFI) measurements of all the animals included at days 7, 14, 21 and 28 was statistically significant (p

Özet

AMAÇ: Çalışmanın amacı, sinir ezilme yaralanması sonrası sinir iyileşmesinde peroperatif lokal deksometazon uygulamasının etkileriniincelemektir.YÖNTEM ve GEREÇLER: 8 hayvan içeren 4 grup hazırlandı. 32 ratta siyatik sinirler orta seviyede açığa kondu ve bunların 24 tanesinde forsepskullanılarak 30 saniye ezilme oluşturuldu.BULGUlAR: Siyatik fonksiyonel indeks (SFI) tüm hayvanlarda 7,14,21 ve 28inci günlerde istatiksel olarak anlamlı idi (p

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Cite This Article

SUSLU, H., ERDIVANLI, B., SUSLU, H. T., ALTUN, M. (2022). Rat Travmatik Siyatik Sinir Modelinde Lokal ve Sistemik Deksametazonun Etkisinin Araştırılması. Turkish Neurosurgery, Cilt: 23 - Sayı: 5, 623–629. https://ajindex.com/articles/617007

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References (1)

  1. Al-Bishri A, Dahlin L, Sunzel B, Rosenquist J: Systemi betamethasone accelerates functional recovery after a crus injury to rat sciatic nerve. J Oral Maxillofac Surg 63:973-977 2005 2. Anders JJ, Borke RC, Woolwry S: Low power laser irradiation alters the rate of regeneration of the rat facial nerve. Laser Surg Med 13: 72-82, 1993 3. Beaudry F, Girard C, Vachon P: Early dexamethasone treatment after implantation of a sciatic nerve cuff decrease the concentration of substance P in the lumbar spinal cord of rats with neuropathic pain. Canadian Journal of Veterinary Research 71:90-97, 2007 4. Burnett MG, Zager EL: Pathophysiology of peripheral nerve injury. Neurosurg Focus 16: 1-7, 2004 5. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M Near terminus axonal structure and function following ra sciatic nerve regeneration through a collagen GAG matrix i a ten millimeter gap. J Neurosci Res 60: 666-677, 2000 6. Clatworthy AL, Illich PA, Castro GA, Walters ET: Role of periaxonal inflammation in the development of thermal hyperalgesia and guarding behaviour in a rat model of neuropathic pain. Neurosci Lett 184:5-8,1995 7. Cunha MTR, Silva AL, Fenelon SB: Comparison of nerve graft integration after segmentar resection versus epineural burying in crushed rat sciatic nerves. Acta Cir Bras 12: 221-225, 1997 8. Dellon AL, Mackinnon SE: Sciatic nerve regeneration in the rat. Validity of walking track assessment in the presence of chronic contractures. Microsurgery 10:220-225,1989 9. De Medinaceli L, Freed W, Wyatt RJ: An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 77:634-643,1982 10. Fernandez E, Pallini R, Lauretti L, Scogna A: Neurosurgery of the peripheral nervous system injuries, degeneration and regeneration of the peripheral nerves. Surg Neurol 48: 446-447, 1997 11. Frostick SP, Yın Q and Kemp GJ: Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery 18: 397-405, 1998 12. Gallowary EB, Jensen RL, Dailey AT, Thompson AT, Shelton C: Role of topical steroids in reducing dysfunction after nerve injury. Laryngoscope 110:1907-1910, 2000 13. Graham WPIII, Pataky PE, Calabretta AM, Munger BL, Buda MJ: Enhancement of peripheral nerve regeneration with triamcinolone after neurorrhaphy. Surg Forum 24: 457-459,1973 14. Hiroaki S, Shinichi K, Heidi H, Robert M: Dexamethasone decreases blood flow in normal nerves and dorsal root ganglia. Spine 27: 581-586, 2002 15.