AI Summary & Key Takeaways
AI InsightMoreover, myelin damage was found to be lower in the SI group than in the I group.CONCLUSION: Systemic application of bone marrow-derived mesenchymal stem cells in a compression model of peripheral nerveinjury has a positive impact on both myelin sheath and axon survival.
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Abstract
AIM: To investigate the effects of systemic application of bone marrow-derived mesenchymal stem cells in a compression modelof peripheral nerve injury.MATERIAL and METHODS: Twenty-four male Wistar albino rats were randomly divided into 3 equal groups (n=8): Control (C), injury(I), and stem cell and injury (SI). The sciatic nerve of the rats in the I and SI groups was subjected to clip compression for 5 minutes.Moreover, approximately 5x105 bone marrow-derived mesenchymal stem cells were given via tail vein of the rats in the SI groupimmediately after clip compression. The nerve conduction velocities and amplitudes of the rats were measured 30 days later. Then,the sciatic nerves were removed, and myelin damage grading and axon counting were performed. The data were analyzed by OneWay ANOVA and Tukey’s post-hoc test. P values less than 0.05 were considered to be statistically significant.RESULTS: While the proximal, distal and mean latency values were higher in the I and SI groups than in the control group, the samemeasurements were lower in the SI group than in the I group. While the nerve conduction velocity, the amplitude of compoundmuscle action potential and the number of axons were lower in the I and SI groups than in the control group, the same measurementswere higher in the SI group than in the I group. Moreover, myelin damage was found to be lower in the SI group than in the I group.CONCLUSION: Systemic application of bone marrow-derived mesenchymal stem cells in a compression model of peripheral nerveinjury has a positive impact on both myelin sheath and axon survival.