The levels were compared between each patient group and between patients and controls.RESULTS: Significant higher neutrophil, platelet counts, NLR and PLR were found in glioma, meningioma and metastasis patientscompared to epilepsy (p
📌 3 Key Takeaways
🎯
Objective & Hypothesis:AIM: To analyze preoperative inflammatory markers including neutrophil, lymphocyte and platelet counts and neutrophil tolymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in a group of patients with different brain pathologies and healthy controls.MATERIAL and METHODS: Above mentioned preoperative inflammatory markers were analyzed in a total of 140 patients included39 with temporal lobe epilepsy, 37 with glioblastoma multiforme, 32 with grade-I meningioma and 32 with intracranial metastasis.Healthy controls included 30 subjects.
📊
Key Findings & Data:AIM: To analyze preoperative inflammatory markers including neutrophil, lymphocyte and platelet counts and neutrophil tolymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in a group of patients with different brain pathologies and healthy controls.MATERIAL and METHODS: Above mentioned preoperative inflammatory markers were analyzed in a total of 140 patients included39 with temporal lobe epilepsy, 37 with glioblastoma multiforme, 32 with grade-I meningioma and 32 with intracranial metastasis.Healthy controls included 30 subjects.
💡
Conclusion & Impact:The levels were compared between each patient group and between patients and controls.RESULTS: Significant higher neutrophil, platelet counts, NLR and PLR were found in glioma, meningioma and metastasis patientscompared to epilepsy (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
AIM: To analyze preoperative inflammatory markers including neutrophil, lymphocyte and platelet counts and neutrophil tolymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in a group of patients with different brain pathologies and healthy controls.MATERIAL and METHODS: Above mentioned preoperative inflammatory markers were analyzed in a total of 140 patients included39 with temporal lobe epilepsy, 37 with glioblastoma multiforme, 32 with grade-I meningioma and 32 with intracranial metastasis.Healthy controls included 30 subjects. The levels were compared between each patient group and between patients and controls.RESULTS: Significant higher neutrophil, platelet counts, NLR and PLR were found in glioma, meningioma and metastasis patientscompared to epilepsy (p
🔖
Cite This Article
TANRIVERDI, T., KEMERDERE, R., BARAN, O., KAYHAN, A., KORKMAZ, T. S., YENI, S. N. (2022). Preoperative Systemic Inflammatory Markers in Different Brain Pathologies: An Analysis of 140 Patients. Turkish Neurosurgery, Cilt: 29 - Sayı: 6, 799–803. https://ajindex.com/articles/616908
Gregory AD, Houghton AM: Tumor-associated neutrophils: New targets for cancer therapy. Cancer Res 71:2411-2416, 2011 2. Han S, Yang L, Qingchang L, Zhonghua L, Haipei H, Anhua W: Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma. BMJ Cancer 15:617- 626, 2015 3. Hanahan D, Weinberg RA: Hallmarks of cancer: The next generation. Cell 144:646-674, 2011 4. Hochberg FH, Atai NA, Gonda D, Hughes MS, Mawajje B, Balaj L, Carter RS: Glioma diagnostics and biomarkers: An ongoing challenge in the field of medicine and science. Expert Rev Mol Diagn 14:439-452, 2014 5. Kawahara T, Fukui S, Sakamaki K, Ito Y, Ito H, Kobayashi N, Izumi K, Yokomizo Y, Miyoshi Y, Makiyama K, Nakaigawa N, Yamanaka T, Yao M, Miyamoto H, Uemura H: Neutrophilto-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy. Oncotarget 31:32169-32176, 2015 6. Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L: The origin and function of tumor-associated macrophages. Immunol Today 13: 265-270, 1992 7. McNamara MG, Lwin Z, Jiang H, Templeton AJ, Zadeh G, Bernstein M, Chung C, Millar BA, Laperriere N, Mason WP: Factors impacting survival following second surgery in patients with glioblastoma in the temazolamide treatment era, incorporating neutrophil/lymphocyte ratio and time to first progression. J Neurooncol 117: 147-152, 2014 8. Vezzani A, French JA, Bartfai T, Baram TZ: The role of inflammation in epilepsy. Nat Rev Neurol 7:31-40, 2011 9. You J, Zhu GQ, Xie L, Liu WY, Shi L, Wang OC, Huang ZH, Braddock M, Guo GL, Zheng MH: Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget 7: 25516-25527, 2016 10. Zadora P, Dabrowski W, Czarko K, Smolen A, KotlinskaHasiec E, Wiorkowski K, Skora A, Jarosz B, Kura K, Rola R, Trojanowski T: Preoperative neutrophil-lymphocyte count ratio helps predict the grade of glial tumor- A pilot study. Neurologia I Neurochirurgia Polska 49: 41-44, 2015 11. Zheng SH, Huang JL, Chen M, Wang BL, Ou QS, Huang SY: Diagnostic value of preoperative inflammatory markers in patients with glioma: A multicenter cohort study. J Neurosurg 129(3):583-592, 2018