AI Summary & Key Takeaways
AI InsightIt was found that the malathion increased alkaline phosphatase activity in the kidney and decreased alkaline phosphatase activity in the liver and small intestine.
📌 3 Key Takeaways
Abstract
The effects of malathion on alkaline phosphatase activity in the liver, kidney and small intestine was investigated. Malathion doses of 40 mg $kg^{-1}$ were injected intreperitonally (1:P) into mice. At 0, 4, 8, 16 and 24 hours after treatment with malathiorrrmice were decapitated and tissues were removed. Homogenate of the tissues was centrifugated at 48000xg for 30 minutes. The supernatant was used as an enzyme source. It was found that the malathion increased alkaline phosphatase activity in the kidney and decreased alkaline phosphatase activity in the liver and small intestine.
Özet
Çalışmamızda malathion'un karaciğer, böbrek ve ince bağırsak alkalen fosfataz aktivitesi üzerine etkisi incelendi. Farelere intraperitonal (I P.) enjeksiyonla 40 mg $kg^{-1}$ malathion dozu verildi. Malathion uygulamasından 0,4,8,16 ve 24 saat sonunda hayvanlar, servikal dislokasyon yoluyla öldürüldü ve dokuları çıkartıldı. Enzim kaynağı olarak dokuların tüm homojenatının 48000xg de 30 dak santrifüj edilmesiyle elde edilen supernatant kullanıldı. Malathion'un böbrek alkalen fosfataz aktivitesini artırıp, karaciğer ve ince bağırsak alkalen fosfataz aktivitesini azalttığı bulundu.