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Journals / Turkish Journal of Veterinary and Animal Sciences / 2002 / Cilt: 26 - Sayı: 5

Comparative study of butorphanol-ketamin HCI and xylazine-ketamin HCI combinations for their clinical and cardiovasclar/respiratory efects in healthy dogs

Köpekler de butorphanol-ketamin HCI kombinasyonunun ksilazin-ketamin HCI kombinasyonuyla klinik ve kardiyovasküler/pulmoner etkileri yönünden karşılaştırılması

İbrahim DEMİRKAN
İsa ÖZAYDIN
Gültekin ATALAN
Halil İbrahim GÖKÇE
Fikret ÇELEBİ
Pages
1073–1079
Publication Date
2022-11-04
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that butorphanol followed by ketamine was comparable with xylazine plus ketamine for the induction of anaesthesia in healthy dogs.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The cardiovascular/respiratory and clinical effects of a xylazine-ketamine combination or a butorphanol-ketamine combination for the induction of anaesthesia in dogs were compared.
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Key Findings & Data:A total of 12 dogs (two groups 6 dogs each) were premedicated with either xylazine (group I) or butorphanol (group II) and anaesthetized with ketamine HCl and monitored at 0, 5, 15, 30 and 60 min after induction.
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Conclusion & Impact:It was concluded that butorphanol followed by ketamine was comparable with xylazine plus ketamine for the induction of anaesthesia in healthy dogs.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The cardiovascular/respiratory and clinical effects of a xylazine-ketamine combination or a butorphanol-ketamine combination for the induction of anaesthesia in dogs were compared. A total of 12 dogs (two groups 6 dogs each) were premedicated with either xylazine (group I) or butorphanol (group II) and anaesthetized with ketamine HCl and monitored at 0, 5, 15, 30 and 60 min after induction. Sedative effects in both groups started within 15 min. Respiratory rate was significantly decreased in group I (P < 0.05). Body temperature was significantly altered after 15 min in group I (P < 0.05 and P < 0.001). Haematological analyses indicated that there were no differences in pH values between the groups. It was concluded that butorphanol followed by ketamine was comparable with xylazine plus ketamine for the induction of anaesthesia in healthy dogs.

Özet

The cardiovascular/respiratory and clinical effects of a xylazine-ketamine combination or a butorphanol-ketamine combination for the induction of anaesthesia in dogs were compared. A total of 12 dogs (two groups 6 dogs each) were premedicated with either xylazine (group I) or butorphanol (group II) and anaesthetized with ketamine HCl and monitored at 0, 5, 15, 30 and 60 min after induction. Sedative effects in both groups started within 15 min. Respiratory rate was significantly decreased in group I (P < 0.05). Body temperature was significantly altered after 15 min in group I (P < 0.05 and P < 0.001). Haematological analyses indicated that there were no differences in pH values between the groups. It was concluded that butorphanol followed by ketamine was comparable with xylazine plus ketamine for the induction of anaesthesia in healthy dogs.

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Cite This Article

DEMİRKAN, İ., ÖZAYDIN, İ., ATALAN, G., GÖKÇE, H. İ., ÇELEBİ, F. (2022). Comparative study of butorphanol-ketamin HCI and xylazine-ketamin HCI combinations for their clinical and cardiovasclar/respiratory efects in healthy dogs. Turkish Journal of Veterinary and Animal Sciences, Cilt: 26 - Sayı: 5, 1073–1079. https://ajindex.com/articles/615642

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References (13)

  1. Haskins, S.C., Patz, J.D., Farver, T.B.: Xylazine and xylazine–ketamine in dogs. Am. J. Vet. Res. 1986
  2. 641 2. Green, S.A., Thurman, J.C.: Xylazine – a review of its pharmacology and use in veterinary medicine. J. Vet. Pharma. Ther. 1981
  3. Klide, A.M., Calderwood, H.W., Soma, L.R.: Cardiopulmonary effects of xylazine in dogs. Am. J. Vet. Res. 1975
  4. Paddleford, R.R., Harvey, R.C.: Alpha-2 agonists and antagonists. Vet. Clin. North Am. Small Anim. Pract. 1999
  5. Gross, M.E., Tranquili, W.J., Thurmon, J.C.: Hemodynamic effects of IV midazolam-xylazine-butorphanol in dogs. Vet. Surg. 1990
  6. Hsu, W.H., Lu, Z.X., Hembrough, F.B.: Effect of xylazine on heart rate and arterial pressure in conscious dogs, as influenced by atropine, 4-aminopyridine, doxapram, and yohimbine. J. Am. Vet. Med. Assoc. 1985
  7. Klide, A.M., Calderwood, H.W., Soma, L.R.: Cardiopulmonary effects of xylazine in dogs. Am. J. Vet. Res. 1975
  8. Kroneberg, G., Oberdorf, H., Hoffmeister, F.: Zur pharmakologie von 2-(2,6-dimethylphenylamino)-4-H-5,6-dihydro-1,3-thiazen (Bayer 1470) eines hemmstoffes adrenergischer und cholinergischer neurone. Naunyn Schmiedebergs Arch Pharmocologie. 1967
  9. Pachter, I.J., Evens, R.P.: Butorphanol.: Drug Alcohol Depend. 1985
  10. Martin, W.R., Eades, C.C., Thompson, J.A., Huppler, R.E., Gilbert, P.E.: The effects of morphine-and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharma. & Exp. Thera. 1976: 197, 517. 11. Pascoe, P.J.: Opioid analgesics. Vet. Clin. North Am. Small Anim. Pract. 2000
  11. Tobin, T., Combie, J., Miller, J.R., Crimson, M.W., Blake, J.W.: Pharmacology of narcotic analjezic in the horse II. Studies on the detection, pharmacokinetics, urinary clearance times and behavioral effects of pentozocine and fentanyl in the horse, Irish Vet. J. 1979
  12. 33 (10): 169-176. 13. Stoelting, R.K.: Nonbarbiturate induction drugs. In: Pharmacology and Physiology in Anaesthetic Practice. Philadelphia, Lippencott, Raven. pp 140-157. 1999. 14. Hall, L.W., Clarke, K.W.: Opioid analgesics. In: Veterinary Anaesthesia. Philadelphia, USA. 64-72, 1991. ISBN 0-70-20- 1421-4. 15. Hirota, K., Lambert, D.G.: Ketamine: its mechanism of action(s) and unusual clinical uses. Br. J. Anaesth. 1996
  13. Hui, T.W., Short, T.G., Hong, W., Suen, T., Gin, T., Plummer, J.: Additive interactions bet