AI Summary & Key Takeaways
AI InsightTe results indicated that 66.66% of TBHB rams and 68.26% of TBHB eweshave scrapie-resistant genotypes, despite the absence of a genetic selection program for scrapie.
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Abstract
A comparison between a rare old breed and a common breed of ovine prion protein (PrP) genotype profles was performed in3 Romanian sheep focks. Te total number of animals used in the research was 698 sheep, of which 53 were Merino breed (MB) rams,12 were Tigaie with Black Head breed (TBHB) rams, 340 were MB ewes, and 293 were TBHB ewes. Te PrP genotype was investigatedby identifcation of codons 136, 154, and 171 and by gene sequencing between codons 101 and 227. All sheep groups contained the ARR,AHQ, ARH, ARQ, and VRQ haplotypes, with frequencies ranging from 1.37% (ARH in TBHB ewes) to 51.71% (ARQ in TBHB ewes).TBHB had a low prevalence of AHQ (2.05% in ewes, 4.17% in rams), ARH (1.37% in ewes, 4.17% in rams), and VRQ (1.88% in ewes,8.33% in rams). Te highest haplotype in TBHB was ARQ (51.71% in ewes, 37.50% in rams). ARQ was the most frequent haplotypein the MB (49.41% in ewes, 42.45% in rams). MB had a low prevalence of AHQ (3.24% in ewes, 6.60% in rams), ARH (1.47% in ewes,5.66% in rams), and VRQ (3.53% in ewes, 9.43% in rams). Te results indicated that 66.66% of TBHB rams and 68.26% of TBHB eweshave scrapie-resistant genotypes, despite the absence of a genetic selection program for scrapie. Te proportion of scrapie resistantalleles was higher in the TBHB rams than in the MB rams.