AI Summary & Key Takeaways
AI InsightVimentin was a very useful marker to show the contribution of fibrotic response to viral replication.
📌 3 Key Takeaways
Abstract
Bovine skin and teat papillomas were examined for immunohistochemical expression of bovine papillomavirus (BPV),proliferating antigens (PCNA, Ki-67), CD3 +T lymphocytes, and some of the type III intermediate filaments. Papillomas showedepidermal hyperplasia, koilocytes, and hyperkeratosis with prominent dermal connective tissue. Immunohistochemistry found thepresence of BPV antigens in the nuclei of granulosa cells. PCNA and Ki-67 revealed positive nuclear staining in the dermis andepidermis. Perivascular cuffing in the dermis predominantly consisted of CD3 +T cells. Immunoreaction to vimentin was strong in theconnective tissue of the dermis. αSMA positivity was mainly in the media of vessels. Smooth muscle cells of the dermal blood vesselsshowed an immunopositive reaction for desmin. Dermal connective tissue and squamous epithelia were negative for S-100 protein. Thiswork revealed that BPV proliferates predominantly in the stratum granulosum cells and that in the regression of warts cell-mediatedimmune response has a key role. Vimentin was a very useful marker to show the contribution of fibrotic response to viral replication.