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Journals / Turkish Journal of Veterinary and Animal Sciences / 2015 / Cilt: 39 - Sayı: 2

Immunohistochemical distribution of platelet-derived growth factor-C and platelet-derived growth factor receptor-α in small intestine of rats treated with capsaicin

Buket BAKIR
Ebru SARI KARADAĞ
Pages
160–167
Publication Date
2022-11-03
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

As a result of statistical analysis, it was found that body weight increased in group 3, while it decreased in groups 1 and 2.

📌 3 Key Takeaways

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Objective & Hypothesis:The purpose of this study was to examine the effect of capsaicin administration immunohistochemically on platelet-derived growth factor (PDGF)-C and platelet-derived growth factor receptor (PDGFR)-α release in the small intestine tissues of rats.
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Key Findings & Data:Rats were divided into three groups: group 1 (subcutaneous drug administration), group 2 (oral drug administration), and group 3 (subcutaneous sham administration).
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Conclusion & Impact:As a result of statistical analysis, it was found that body weight increased in group 3, while it decreased in groups 1 and 2.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The purpose of this study was to examine the effect of capsaicin administration immunohistochemically on platelet-derived growth factor (PDGF)-C and platelet-derived growth factor receptor (PDGFR)-α release in the small intestine tissues of rats. Rats were divided into three groups: group 1 (subcutaneous drug administration), group 2 (oral drug administration), and group 3 (subcutaneous sham administration). Histometric measurements and counts were performed in order to determine whether there was a difference between groups in terms of height of villi, depth of crypts, and goblet cell count in small intestine. The small intestine was examined by Crossman s triple staining method and streptavidin-biotin peroxidase complex method. As a result of statistical analysis, it was found that body weight increased in group 3, while it decreased in groups 1 and 2. Capsaicin administration increased height of villi, depth of crypts, and count of goblet cells located on villi and crypts. Immunohistochemical examinations revealed that capsaicin administration increased PDGF-C and PDGFR-α release. It was concluded that capsaicin has a stimulatory effect on growth and is an enhancer for PDGF-C and PDGFR-α release.

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Cite This Article

BAKIR, B., KARADAĞ, E. S. (2022). Immunohistochemical distribution of platelet-derived growth factor-C and platelet-derived growth factor receptor-α in small intestine of rats treated with capsaicin. Turkish Journal of Veterinary and Animal Sciences, Cilt: 39 - Sayı: 2, 160–167. https://ajindex.com/articles/615212

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