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Journals / Turkish Journal of Veterinary and Animal Sciences / 2017 / Cilt: 41 - Sayı: 4

Morphological abnormalities of blood and bone marrow leukocytes and age-related changes in different leukocyte counts in the American mink (Neovison vison)

Lyudmila UZENBAEVA
Viktor ILYUKHA
Nikolay TYUTYUNNIK
Aleksandra KIZHINA
Pages
570–577
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The levels of abnormal segmented neutrophils and abnormal lymphocytes were higher in adult mink as compared with puppies (4-, 10-day-old).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The sapphire mink is a unique animal model to study cellular morphology.
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Key Findings & Data:It demonstrates abnormal leukocytes like in patients with Chédiak Higashi syndrome.
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Conclusion & Impact:The levels of abnormal segmented neutrophils and abnormal lymphocytes were higher in adult mink as compared with puppies (4-, 10-day-old).
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The sapphire mink is a unique animal model to study cellular morphology. It demonstrates abnormal leukocytes like in patients with Chédiak Higashi syndrome. We aimed to determine the morphologic features of blood and bone marrow leukocytes in the sapphire mink and dark-brown mink (wild type). In addition, were assessed age-related changes in total white blood cell (WBC) and differential WBC counts. We conclude that the sapphire mink has a morphological leukocyte defect (abnormal granules). We observed that abnormal granules formed at an early stage of bone marrow leukocyte maturation. It was shown that the leukocyte profile of young mink differs from that of adult animals. The levels of abnormal segmented neutrophils and abnormal lymphocytes were higher in adult mink as compared with puppies (4-, 10-day-old).

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Cite This Article

UZENBAEVA, L., ILYUKHA, V., TYUTYUNNIK, N., KIZHINA, A. (2022). Morphological abnormalities of blood and bone marrow leukocytes and age-related changes in different leukocyte counts in the American mink (Neovison vison). Turkish Journal of Veterinary and Animal Sciences, Cilt: 41 - Sayı: 4, 570–577. https://ajindex.com/articles/615058

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References (14)

  1. Trapezov OV, Trapezova LI, Alekhina TA, Klochkov DV, Ivanov IN. Effects of monorecessive and double recessive mutations affecting coat color on the monoamine content of the brain of the American mink (Neovison vison Schreber, 1777). Russian Journal of Genetika 2009; 45: 1641-1645
  2. Vagin IV. Effect of aleutian gene on mink (Neovison vison) growth. Cytology and Genetika 2003; 37: 16-19 (article in Russian with an English abstract)
  3. Oliver C, Essner E. Formation of anomalous lysosomes in monocytes, neutrophils, and eosinophils from bone marrow of mice with Chediak-Higashi syndrome. J Histochem Cytochem 1973; 32: 17-27
  4. Uzenbaeva LB, Trapezov OV, Kizhina AG, Iliukha VA, Trapezova LI, Tiutiunnik NN. Effect of mutations affecting coat color on the blood lymphocyte structure in the American mink (Neovison vison Schreber, 1777). Genetika 2011; 47: 87-94
  5. Kramer JW, Davis WC, Prieur DJ. The Chediak-Higashi syndrome of cats. Lab Invest 1977; 36: 554-562
  6. Nishimura M, Inoue M, Nakano T, Nishikawa T, Miyamoto M, Kobayashi T, Kitamura Y. Beige rat a new animal model of Chediak-Higashi syndrome. Blood 1989; 74: 270-273
  7. Oliver C, Essner E. Distribution of anomalous lysosomes in the beige mouse: a homologue of Chediak-Higashi syndrome. J Histochem Cytochem 1973; 21: 218-228
  8. Ozaki K, Maeda H, Uechi S, Yamate H, Nishikawa T, Nishimura M, Narama I. The presence of giant granules in the juxtaglomerular cells of beige rats may affect plasma rennin activity and blood pressure. Exp Mol Path 1994; 61: 221-229
  9. Anistoroaei R, Krogh AK, Christensen K. A frameshift mutation in the LYST gene is responsible for the Aleutian color and the associated Chédiak–Higashi syndrome in American mink. Anim Genet 2012; 44: 178-183
  10. Blume RS, Padgett GA, Wolf SM, Bennett JM. Neutrophil granules in the Chediak-Higashi syndrome of man, mink, cattle and mice. Can J Comp Med 1969; 33: 271-274
  11. Hammer AS, Andersen TH, Eriksen T, Kortegaard HE, Dietz HH, Chriél M. Radiographic evaluation of destructive periodontal disease in blue mink in relation to age and blood morphology. Can J Vet Res 2005; 69: 128-134
  12. Aulerich RJ, Heil CR, Lehning EL, Ringer RK. Leukocyte ratios kits from birth to 10 age. Scientifur 1976; 13: 104-110
  13. Coe JE, Race RE. Ontogeny of mink IgG, IgA, and IgM. Proc Soc Exp Biol Med 1978; 157: 289-292
  14. Jain NC. Comparative hematologic features of some avian and mammalian species. In: Jain NC, editor. Essentials of Veterinary Hematology. 1st