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Journals / Turkish Journal of Pediatrics / 2015 / Cilt: 57 - Sayı: 6

Transient hypogammaglobulinemia of infancy: predictive factors for late recovery

Murat SÜTÇÜ
Sezen GÜLÜMSER-ŞİŞKO
Manolya ACAR
Deniz ÖZÇEKER
Nuran SALMAN
Ayper SOMER
Hacer AKTÜRK
Pages
592–598
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Breastfeeding should be encouraged and IVIG should be used in well selected patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:SUMMARY: Sütçü M, Aktürk H, Salman N, Özçeker D, Gülümser-Şişko S, Acar M, Somer A.
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Key Findings & Data:Turk J Pediatr 2015; 57: 592-598.
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Conclusion & Impact:Breastfeeding should be encouraged and IVIG should be used in well selected patients.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

SUMMARY: Sütçü M, Aktürk H, Salman N, Özçeker D, Gülümser-Şişko S, Acar M, Somer A. Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. Turk J Pediatr 2015; 57: 592-598. This study evaluates the clinical/immunological features and outcomes of 91 patients with the diagnosis of transient hypogammaglobulinemia of infancy(THI). Mean age at diagnosis was 8.4±5.2 months. IgG levels normalized at 30.6±11.88 months. Sixty three patients (69.3%) resolved in their first 3 years of life and 28 patients (30.7%) thereafter. In the univariate analysis, presence of atopy, occurrence of recurrent infections (>6/year) and hospitalization, initial low IgA and IgM levels were found to be associated with the late recovery. Patients with longer breastfeeding duration recovered earlier. Recovery time for Ig levels was found to be longer in patients who received IVIG (n=55, 60.4%). This study confirmed that delayed resolution in THI is not rare. Frequent infections, initial low IgA and/or IgM levels and presence of atopy were found as associated factors for the late recovery. Breastfeeding should be encouraged and IVIG should be used in well selected patients.

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Cite This Article

SÜTÇÜ, M., GÜLÜMSER-ŞİŞKO, S., ACAR, M., ÖZÇEKER, D., SALMAN, N., SOMER, A., AKTÜRK, H. (2022). Transient hypogammaglobulinemia of infancy: predictive factors for late recovery. Turkish Journal of Pediatrics, Cilt: 57 - Sayı: 6, 592–598. https://ajindex.com/articles/613255

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