SavedAdd your journal

Journals / Turkish Journal of Obstetrics and Gynecology / 2019 / Cilt: 16 - Sayı: 2

Increased nuchal translucency and pregnancy outcomes: experience of Başkent University Ankara Hospital

Artmış ense saydamlığı ve gebelik sonuçları: Başkent Üniversitesi Ankara Hastanesi deneyimi

Filiz BİLGİN YANIK
Nihal ŞAHİN UYSAL
Çağrı GÜLÜMSER
Zerrin YILMAZ ÇELİK
Pages
100–106
Publication Date
2022-11-06
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our study indicates that fetal echocardiography must be considered for allcases with increased NT.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: First trimester nuchal translucency (NT) measurement is considered to be an important tool in antenatal follow-up.
📊
Key Findings & Data:This study aimed to evaluatethe outcomes of pregnancies with increased NT at Başkent University Ankara Hospital between 2004 and 2016.Materials and Methods: Patients with NT measurements ≥1.5 multiples of median (MoM) were divided into two groups; group I included increased NTcases without fetal anomalies (either abnormal fetal karyotype or congenital structural anomalies) or loss (intrauterine fetal death), and group II includedincreased NT cases with fetal anomalies or loss.
💡
Conclusion & Impact:Our study indicates that fetal echocardiography must be considered for allcases with increased NT.
🔬Design:Research Article
📍Scope:2004 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: First trimester nuchal translucency (NT) measurement is considered to be an important tool in antenatal follow-up. This study aimed to evaluatethe outcomes of pregnancies with increased NT at Başkent University Ankara Hospital between 2004 and 2016.Materials and Methods: Patients with NT measurements ≥1.5 multiples of median (MoM) were divided into two groups; group I included increased NTcases without fetal anomalies (either abnormal fetal karyotype or congenital structural anomalies) or loss (intrauterine fetal death), and group II includedincreased NT cases with fetal anomalies or loss. The groups were compared with each other with respect to maternal demographic features and NTmeasurements.Results: Karyotype analyses were normal in 73.1% of cases with increased NT (57/78). Among those, 21.1% (12/57) had structural anomalies, and tospecify, 9.6% (5/52 over 18 weeks) had cardiac anomalies. Although maternal demographic features did not differ significantly, NT measurements, bothas millimeters and MoM, were significantly higher in group II (p7 millimeters or NT MoM >4.27resulted in poor fetal outcomes without exception.Conclusion: Higher NT measurements indicate poorer pregnancy outcomes. Our study indicates that fetal echocardiography must be considered for allcases with increased NT.

Özet

Amaç: Birinci trimester ense saydamlığı (NT) ölçümü antenatal takipte önemli bir araç olarak kabul edilmektedir. Bu çalışmada Başkent Üniversitesi Ankara Hastanesi’nde 2004-2016 yılları arasındaki artmış NT’si olan gebeliklerin sonuçlarını değerlendirmeyi amaçladık. Gereç ve Yöntemler: NT ölçümleri ≥1,5 MoM olan olgular iki gruba ayrıldı. Grup I artmış NT’ye fetal anomalilerin (anormal fetal karyotip, konjenital yapısal anomaliler) veya kaybın (intrauterin fetal ölüm) eşlik etmediği olguları içerirken; grup II artmış NT’ye fetal anomalilerin veya kaybın eşlik ettiği olguları içerdi ve gruplar maternal demografik özellikleri ve NT ölçümlerine göre birbirleri ile karşılaştırıldı. Bulgular: NT artışı olan olguların %73,1’inde karyotip analizleri normaldi (57/78). Bunların arasında, %21,1’inde yapısal anomaliler vardı ve %9,6’sında (18 hafta üzeri 5/52) kardiyak anomalilerin olduğu belirlendi. Maternal demografik özellikler önemli ölçüde farklılık göstermemesine rağmen, NT ölçümleri hem milimetre hem de MoM değerleri olarak grup II’de anlamlı derecede daha yüksekti (n=35) (p7 mm veya NT MoM >4,27 istisnasız kötü fetal sonuçlarla sonuçlandı. Sonuç: Daha yüksek NT ölçümleri daha olumsuz gebelik sonuçlarına işaret eder. Bizim çalışmamız fetal ekokardiyografinin NT artışı olan tüm olgular için düşünülmesi gerektiğini gösterdi.

🔖

Cite This Article

YANIK, F. B., UYSAL, N. Ş., GÜLÜMSER, Ç., ÇELİK, Z. Y. (2022). Increased nuchal translucency and pregnancy outcomes: experience of Başkent University Ankara Hospital. Turkish Journal of Obstetrics and Gynecology, Cilt: 16 - Sayı: 2, 100–106. https://ajindex.com/articles/613012

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Nicolaides KH, Sebire NJ, Snijders RJ. Nuchal translucency and chromosomal defects. In: Nicolaides KH, Sebire NJ, Snijders RJ, editors. The 11-14-week scan: The diagnosis of fetal abnormalities. 1999:6-10 Parthenon Publishing
  2. Nicolaides KH. Nuchal translucency and other first trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004;191:45-67
  3. Nicolaides KH, Sebire NJ, Snijders RJ. Pathophysiology of increased nuchal translucency. In: Nicolaides KH, Sebire NJ, Snijders RJ, editors.The 11-14-week scan: The diagnosis of fetal abnormalities. 1999:95 Parthenon Publishing
  4. Desilets V, Audibert F. Investigation and management of nonimmune fetal hydrops. J Obstet Gynaecol Can 2013;35:923-38
  5. Kagan KO, Avgidou K, Molina FS, Gajewska K, Nicolaides KH. Relation between increased fetal nuchal translucency thickness and chromosomal defects. Obstet Gynecol 2006;107:6-10
  6. Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH. Increased nuchal translucency with normal karyotype. Am J Obstet Gynecol 2005;192:1005-21
  7. Pandya PP, Brizot ML, Kuhn P, Snijders RJ, Nicolaides KH. Firsttrimester fetal nuchal translucency thickness and risk for trisomies. Obstet Gynecol 1994;84:420-23
  8. Pan M, Han J, Zhen L, Yang X, Li R, Liao C, et al. Prenatal diagnosis of fetuses with increased nuchal translucency using an approach based on quantitative fluorescent polymerase chain reaction and genomic microarray. Eur J Obstet Gynecol Reprod Biol 2016;197:164-7
  9. Lithner CU, Kublickas M, Ek S. Pregnancy outcome for fetuses with increased nuchal translucency but normal karyotype. J Med Screen 2016;23:1-6
  10. Hyett J. Does nuchal translucency have a role in fetal cardiac screening? Prenat Diagn 2004:24:1130-5
  11. Nicolaides KH. Nuchal translucency and other first trimester sonographic markers of chromosomal abnormalities. Am J Obstet Gynecol 2004;191:45-67
  12. Atzei A, Gajewska K, Huggon IC, Allan L, Nicolaides KH. Relationship between nuchal translucency thickness and prevalence of major cardiac defects in fetuses with normal karyotype. Ultrasound Obstet Gynecol 2005;26:154e7
  13. Muller MA, Clur SA, Timmerman E, Bilardo CM. Nuchal translucency measurement and congenital heart defects: modest association in low-risk pregnancies. Prenat Diagn 2007;27:164-9
  14. Mavrides E, Cobian-Sanchez F, Tekay A, Moscoso G, Campbell S, Thilaganathan B, et al. Limitations of using first-trimester nuchal translucency measurement in routine screeni