Journals / Turkish Journal of Obstetrics and Gynecology / 2019 / Cilt: 16 - Sayı: 4

Immunoglobulin G4 deficiency can be a new entity for primary recurrent miscarriage: Successful pregnancy in two cases after treatment with intravenous immunoglobulin

IgG4 eksikliği, primer tekrarlayan düşük için yeni bir oluşum olabilir: İntravenöz immünoglobulin ile tedavi sonrası iki olguda başarılı gebelik

Pages
274–277
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It is expected that theseresults will shed further light on the feasibility of intravenous Ig for women with recurrent miscarriage.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Recurrent miscarriage is one of the complications of pregnancy in which the potential role of immunologic factors has already been mentioned.
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Key Findings & Data:The diagnosis of immunoglobulin G4 (IgG4) deficiency was made through the reductionof IgG4 Ig levels and normal total IgG titer.
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Conclusion & Impact:It is expected that theseresults will shed further light on the feasibility of intravenous Ig for women with recurrent miscarriage.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Recurrent miscarriage is one of the complications of pregnancy in which the potential role of immunologic factors has already been mentioned. Here, two youngwomen with recurrent miscarriage were consulted in the infertility center. The diagnosis of immunoglobulin G4 (IgG4) deficiency was made through the reductionof IgG4 Ig levels and normal total IgG titer. Considering this abnormality, intravenous Ig 200 mg/kg was started monthly, and they both had successful pregnancies.Little is known about IgG4 deficiency in women with recurrent miscarriage. IgG4 deficiency should be taken into account in these patients. It is expected that theseresults will shed further light on the feasibility of intravenous Ig for women with recurrent miscarriage.

Özet

İmmünolojik faktörlerin potansiyel bir rolünün olduğu belirtilen tekrarlayan düşük, gebeliğin komplikasyonlarından biridir. Burada, tekrarlayan düşüğü olan iki genç kadın infertilite merkezinde değerlendirildi. IgG4 eksikliğinin tanısı, IgG4 immünoglobulin seviyelerindeki ve normal toplam IgG titresindeki düşüşle konuldu. Bu anormallik dikkate alındığında, ayda 200 mg/kg intravenöz immünoglobulin başlandı ve her iki hastada da başarılı gebelikler elde edildi. Tekrarlayan düşüğü olan kadınlardaki IgG4 eksikliği hakkında çok az şey bilinmektedir. IgG4 eksikliği bu hastalarda dikkate alınmalıdır. Bu sonuçların, tekrarlayan düşüğü olan kadınlarda intravenöz immünoglobulinin uygulanabilirliğine daha fazla ışık tutması beklenmektedir.

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Cite This Article

MOGHTADERI, M., SHAKERIAN, B., HEIDARI, N. (2022). Immunoglobulin G4 deficiency can be a new entity for primary recurrent miscarriage: Successful pregnancy in two cases after treatment with intravenous immunoglobulin. Turkish Journal of Obstetrics and Gynecology, Cilt: 16 - Sayı: 4, 274–277. https://ajindex.com/articles/613003

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