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Journals / Turkish Journal of Obstetrics and Gynecology / 2020 / Cilt: 17 - Sayı: 4

Endometrial CD56+ natural killer cells in women with recurrent implantation failure: An immunohistochemical study

Tekrarlayan implantasyon başarısızlıklarında endometriyal CD56+ natürel killer hücreleri: İmmünohistokimyasal çalışma

Pembe OLTULU
Burak GİRAY
Mehmet Cengiz ÇOLAKOĞLU
Gulchin BABAYEVA
Yunus Emre PURUT
Rabia ALAKUŞ
Pages
12–15
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: There was a statistically significant difference between the groups concerning the number of deliveries (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Implantation failure is a multifactorial problem of reproductive medicine.
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Key Findings & Data:The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth.
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Conclusion & Impact:Results: There was a statistically significant difference between the groups concerning the number of deliveries (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Implantation failure is a multifactorial problem of reproductive medicine. However, the mechanism of this process is still not fully understood. There is increasing evidence that these cases of recurrent implantation failure might have an immunologic background. Uterine natural killer (NK) cells provide immune-modulation at the interface between maternal decidua and the trophoblast. The aim of this study to evaluate whether there was a significant difference in the number of endometrial CD56+ NK between women with a history of recurrent implantation failure and women who had a live birth. Materials and Methods: Patients with a history of recurrent implantation failure were included in the study. Twenty-five women with a history of recurrent implantation failure were assigned to the case group, and 25 women who had one or more live births were assigned to the control group. Endometrial biopsies were obtained during the luteal phase on the 21st-24th day of the menstrual cycle. Results: There was a statistically significant difference between the groups concerning the number of deliveries (p

Özet

Amaç: İmplantasyon başarısızlıkları reprodüktif tıbbın multifaktöriyel bir problemidir. Tam mekanizması günümüzde halen aydınlatılamamıştır. Son yıllarda mekanizmasında immünolojik faktörlerin etkili olduğuna dair kanıtlar artmaktadır. Uterin natürel killer (uNK) hücreleri trofoblastlar ile desidua arasında immün modülasyonu sağlar. Çalışmamızın amacı tekrarlayan implantasyon başarısızlığı olan olgular ile canlı doğuma sahip olan kadınlar arasında uNK hücreleri açısından fark olup olmadığının araştırılmasıdır. Gereç ve Yöntemler: Çalışmaya tekrarlayan implantasyon başarısızlığı olan hastalar dahil edildi. Yirmi beş implantasyon başarısızlığı olan hasta olgu grubunu, 25 canlı doğum öyküsü olan kadın ise kontrol grubunu oluşturdu. Endometriyal biyopsiler menstruel döngünün 21. ile 24. günleri arasında luteal fazda alındı. Her iki grup uNK açısından karşılaştırıldı. Bulgular: Her iki grup arasında canlı doğum (p

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Cite This Article

OLTULU, P., GİRAY, B., ÇOLAKOĞLU, M. C., BABAYEVA, G., PURUT, Y. E., ALAKUŞ, R. (2022). Endometrial CD56+ natural killer cells in women with recurrent implantation failure: An immunohistochemical study. Turkish Journal of Obstetrics and Gynecology, Cilt: 17 - Sayı: 4, 12–15. https://ajindex.com/articles/612936

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