Journals / Turkish Journal of Obstetrics and Gynecology / 2021 / Cilt: 18 - Sayı: 4

Effects of growth hormone co-treatment on in vitro fertilization outcomes in women with expected normal ovarian response

Büyüme hormonu ko-tedavisinin normal ovaryan cevap beklenen infertil kadınların IVF sonuçlarına etkisi

Pages
284–290
Publication Date
2022-11-06
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The number of obtained 2PN embryos (5.68±2.46 vs 5.06±2.5; p=0.003), fertilization rates (0.84±0.16 vs 0.76±0.18; p

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to evaluate the effects of adjuvant growth hormone (GH) therapy on in vitro fertilization outcomes in women with infertility with expected normal ovarian response who underwent gonadotropin-releasing hormone (GnRH) antagonist protocol with dual triggering.
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Key Findings & Data:Materials and Methods: Records of women who underwent GnRH antagonist cycles with dual triggering in a single tertiary center between 2017 and 2020 were retrospectively analyzed.
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Conclusion & Impact:The number of obtained 2PN embryos (5.68±2.46 vs 5.06±2.5; p=0.003), fertilization rates (0.84±0.16 vs 0.76±0.18; p
🔬Design:Research Article
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: This study aimed to evaluate the effects of adjuvant growth hormone (GH) therapy on in vitro fertilization outcomes in women with infertility with expected normal ovarian response who underwent gonadotropin-releasing hormone (GnRH) antagonist protocol with dual triggering. Materials and Methods: Records of women who underwent GnRH antagonist cycles with dual triggering in a single tertiary center between 2017 and 2020 were retrospectively analyzed. A total of 1054 women with expected normal ovarian response were evaluated, of which 131 were found to receive GH cotreatment (study group). Moreover, 950 women did not receive any adjuvant therapy (control group). Their cycle outcomes were compared. Results: The number of retrieved oocytes, oocyte maturation rates, quality of embryos, miscarriage rates, and multiple pregnancy rates were comparable among women who underwent GnRH antagonist cycles with and without GH co-treatment. The number of obtained 2PN embryos (5.68±2.46 vs 5.06±2.5; p=0.003), fertilization rates (0.84±0.16 vs 0.76±0.18; p

Özet

Amaç: Adjuvan büyüme hormonu kullanımının GnRH antagonist sikluslarında dual trigger uygulanan normal ovaryan cevap beklenen infertil kadınlarda siklus sonuçları üzerine etkisini araştırmaktadır. Gereç ve Yöntemler: Üçüncü basamak bir infertilite merkezinde 2017 ile 2020 yılları arasında dual trigger ile GnRH antagonist siklusu uygulanan kadınların verileri retrospektif olarak taranmıştır. Toplamda 1054 normal ovaryan cevap beklenen infertil kadın çalışmaya dahil edilmiştir. Yüz otuz bir hasta adjuvan büyüme hormonu almış ve çalışma grubuna dahil edilmiştir. Dokuz yüz elli üç hasta kontrol grubu olarak belirlenmiş ve siklus sonuçları karşılaştırılmıştır. Bulgular: Elde edilen oosit sayısı, oosit matürasyon oranları, embriyo kalitesi, düşük oranları, çoğul gebelik oranları açısından çalışma ve kontrol grupları arasında fark bulunmamıştır. Elde edilen 2PN embriyo sayısı (5,68±2,46 vs 5,06±2,5; p=0,003), fertilizasyon oranları (0,84±0,16 vs 0,76±0,18; p

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Cite This Article

TÜLEK, F., KAHRAMAN, A. (2022). Effects of growth hormone co-treatment on in vitro fertilization outcomes in women with expected normal ovarian response. Turkish Journal of Obstetrics and Gynecology, Cilt: 18 - Sayı: 4, 284–290. https://ajindex.com/articles/612920

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