Journals / Turkish Journal of Medical Sciences / 1998 / Cilt: 28 - Sayı: 6

Effect of selenium on ''low T3 syndrome '' in hepatic failure

Pages
649–653
Publication Date
2022-11-05
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Triiodothyronine occurs especially in S'-monodeiodination of thyroxin in peripheral tissues.
📊
Key Findings & Data:Deiodinase enzyme activity and the triiodothyronine level decrease in selenium deficiency.
💡
Conclusion & Impact:Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Triiodothyronine occurs especially in S'-monodeiodination of thyroxin in peripheral tissues. Deiodination of thyroxin mainly occurs in the liver. The enzyme which catalyzes this reaction is a seleno-enzyme. Deiodinase enzyme activity and the triiodothyronine level decrease in selenium deficiency. After the occurrence of chronic hepatic failure by carbon tetrachloride in rats, we gave sodium selenite to these rats. Then, we tried to evaluate the changes in thyroid hormone levels. Liver function tests, thyroxin and triiodothyronine levels, and hepatic 5'-deiodinase and glutathione peroxidase enzyme activities were measured. Triiodothyronine levels in the carbon tetrachloride group and carbon tetrachloride + selenium group were significantly lower than in the control group (P

🔖

Cite This Article

DÖNDER, E., NAZIROĞLU, M., BAYDAŞ, G., İLHAN, N., ÇAY, M. (2022). Effect of selenium on ''low T3 syndrome '' in hepatic failure. Turkish Journal of Medical Sciences, Cilt: 28 - Sayı: 6, 649–653. https://ajindex.com/articles/612654

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Coombs GF., Coombs SB. Selenium andCancer. In: Coombs GF., ed. The role ofselenium in nutrition, Academic Press,Orlando, 1986, 413–61. 2.L’Abbe MR., Fischer PWF., Cambelli JS.,Chavez ER. Effects of dietary seleniumon DMBA–induced carcinogenesis inrats fed a diet high in mixed fats. J Nutr119: 757–65, 1989. 3.Halverson AW. Growth andreproduction with rats fed selenite–Se.Proc S Dakota Acad Sci 53: 167–77,1974. 4.Willet WC., Morris JS., Pressel S.,Taylor JO., Polk BF., Stampfer MJ.Prediagnostic serum selenium and riskof cancer. Lancet 2: 130–4, 1985. 5.Har JR., Exon JH., Whanger PD.,Weswig PH. Effect of dietarysupplementation on N–2–fluorenyl–acetamide (FAA)–induced cancer invitamin E supplemented seleniumdepleted rats. Clin Toxicol 5: 187–94,1972. 6.Beckett GJ., Beddows SE., MorricePC., Nicol F., Arthur JR. Inhibition ofhepatic deiodination of thyroxine iscaused by selenium deficiency in rats.Biochem J 248: 443–7, 1987 7.Beckett GJ., Nicol F., Proudfoot D.,Dyson K., Loucaides G., Arthur JR. Thechanges in hepatic enzyme expressioncaused by selenium deficiency andhypothyroidism in rats are produced byindependent mechanisms. Biochem J266: 743–7, 1990. 8.Meinhold H., Campos–Barros A.,Walzog B., Köhler R., Müller F. Effectsof selenium and iodine deficiency ontype I, type II, and type III iodothyroninedeiodinases and circulating thyroidhormone in rats. Exp Clin Endocrinol101: 87–93, 1993. 9.Beckett GJ., Russel A., Nicol F., SahuP., Wolf C., Arthur JR. Effect ofselenium deficiency on hepatic type I5–iodothyronine deiodinase activityand hepatic thyroid hormone level inthe rat. Biochem J 282: 483–6, 1992. 10.Chanoine JP., Safran M., Farwel AP.,Dubord S., Alex S., Stone S. Effects ofselenium deficiency on thyroidhormone economy in rats. Endocrinol131: 1787–92, 1992. 11.Chopra IJ. A study of extrathyroidalconversion by thyroxine (T4) to 3, 3’,5–triiodothyronine (T3) in vitro.Endocrinol 101: 453–63, 1977. 12.Kabadi UM., Premachandra BN. Lowserum T3 and raised reverse T3 levelsin hepatic cirrhosis: role of glucagon. J.Gastroenterol 86: 1504–7, 1991. 13.Arthur JR., Morrice PC., Nicol F.,Beddows SE., Boyd R., Hayes JD.,Beckett GJ. The effects of selenium andcopper deficiencies on glutathioneS–transferase and glutathioneperoxidase in rat liver. Biochem J 248:539–44, 1987. 14.Burman KD., Smallridge RC., Jones L.,Ramos EA. Glucagon kinetics infasting: Physiological elevation inserum 3, 5, 3’–triiodothyronineincrease the metabolic clearence rate ofglucagon. J Clin Endocrino