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Journals / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 2

Administration of Granulocyte Colony Stimulating Factor (G-CSF) in Experimentally Infected Rats

Ömer CEVİT
Gökhan KÖYLÜOĞLU
Asım GÜLTEKİN
Fatoş TANZER
Dilara İÇAĞASIOĞLU
Ruhiye CEVİT
Pages
109–112
Publication Date
2022-11-05
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p

📌 3 Key Takeaways

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Objective & Hypothesis:We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats.
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Key Findings & Data:In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli.
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Conclusion & Impact:Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:G-CSF · E. coli sepsis · neutropenia.

Abstract

We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli. Rats were divided into four treatment groups before being inoculaded with E. coli in a random fashion. Therapy was then started with cefotaxime (150 mg/kg intraperitonelally) and either Granulocyte-Colony Stimulation Factor (G-CSF; 30 µg/kg intarperitoneally) or placebo 24 hours after inoculation of E. coli for 3 consective days. Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p

Özet

We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli. Rats were divided into four treatment groups before being inoculaded with E. coli in a random fashion. Therapy was then started with cefotaxime (150 mg/kg intraperitonelally) and either Granulocyte-Colony Stimulation Factor (G-CSF; 30 µg/kg intarperitoneally) or placebo 24 hours after inoculation of E. coli for 3 consective days. Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p

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Cite This Article

CEVİT, Ö., KÖYLÜOĞLU, G., GÜLTEKİN, A., TANZER, F., İÇAĞASIOĞLU, D., CEVİT, R. (2022). Administration of Granulocyte Colony Stimulating Factor (G-CSF) in Experimentally Infected Rats. Turkish Journal of Medical Sciences, Cilt: 29 - Sayı: 2, 109–112. https://ajindex.com/articles/612567

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