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Journals / Turkish Journal of Medical Sciences / 2000 / Cilt: 30 - Sayı: 5

The radioprotective effect of vitamins C, E and vitamin E + glutathione on the small intestine and the thyroid gland in rats irradiated with X-rays

Cemil SERT
Yusuf NERGİZ
Zülküf AKDAĞ
M. Salih ÇELİK
M. Aydın KETANİ
Pages
417–425
Publication Date
2022-11-05
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Significant T3 and TSH level changes (p

📌 3 Key Takeaways

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Objective & Hypothesis:This investigation was carried out in order to determine the protective effects of long term administration at supraphysiologi- cal doses of vitamin E, vitamin C and a compound of vitamin E + glutathione against damage induced by free radicals produced by ionizing radiation.
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Key Findings & Data:Five groups of 8-10-week-old Wistar albino rats were used in the study.
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Conclusion & Impact:Significant T3 and TSH level changes (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This investigation was carried out in order to determine the protective effects of long term administration at supraphysiologi- cal doses of vitamin E, vitamin C and a compound of vitamin E + glutathione against damage induced by free radicals produced by ionizing radiation. Five groups of 8-10-week-old Wistar albino rats were used in the study. Group I was the sham group and Group II was the radiation group (i.e. radiation alone). The rats in Group III were given a daily dose of 400 mg/kg of vit. C for one month. The rats in Group IV were given a daily dose of vit. E for one month. The rats in Group V received a mix- ture of 400 mg/kg vit. E plus 1000 mg/kg of glutathione per day for 15 days. All the com- pounds were administered via a nasogastric tube. At the end of the drug administration period, the rats in all but the sham group were exposed to X-ray with an radiation ener- gy dose of 8.90 Gy. All the rats were sacri- ficed 1 day after irradiation. Thyroid and intestinal tissues were examined for histopathological changes and T3 , T4 , TSH hormone levels were determined by radioim- munoassay (RIA). The radiation damage observed in the thy- roidal and intestinal cross-sections of the Group II rats was also seen to a lesser extent in the Group III (vit. C group) and Group IV (vit. E) rats. Toxic effects were observed in the Group V (vit. E + glutathione) rats. Significant T3 and TSH level changes (p

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Cite This Article

SERT, C., NERGİZ, Y., AKDAĞ, Z., ÇELİK, M. S., KETANİ, M. A. (2022). The radioprotective effect of vitamins C, E and vitamin E + glutathione on the small intestine and the thyroid gland in rats irradiated with X-rays. Turkish Journal of Medical Sciences, Cilt: 30 - Sayı: 5, 417–425. https://ajindex.com/articles/612442

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