A father born to consanguineous parents had double translocation 21;22 [44,XY, t(21q;22q), t(21q;22q)] due to familial translocation in four generations

References (7)

1. Motulsky V: Human Genetics, 3rd ed., Springer Co. London, 1996, 589
2. Friedman JMI, Dill F, Haydan MR, Mc Gillivary BC: Genetics, Harwal Publishing Co, Malvern, Pennsylvania 1992, 36-7
3. Erciş M, Balcı S. Can a parent with balanced Robertsonian translocation t(21q;21q) have a non-Down's offspring? Lancet 353 (9154): 751, 1999 4. Balcı S, Beksaç S, Altaş D. An unusual familial chromosomal translocation in both parents: mother 45,XX,t(14q;21q), father 46,XY,t(1;4) (p36.1;p14). Result of eleven pregnancies (the last child had 45,XX t(14q;21q)del(4)(p14) Wolf Hirschorn Syndrome) with clinical, cytogenetic and postmortem findings. Cytogenet Cell Genet 85: 575, 1999 5. Rajangam S, Michaelis RC, Velagaleti GVN, Lincol S, Hegde S, Lewin S, Tarkton J, Thomas IM. Down Syndrome with biparental inheritance of der(14q21q) and maternally derived Trisomy 21: Confirmation by FISH and microsatellite polymorphism analysis. Am J Med Genet 70: 43-47, 1997
4. Bijlsma JB, de France HF, Bleeker- Wagemakers LM, Dijkstra PF. Double translocation t(7;12),t(2;6) heterozygosity in one family. A contribution to the trisomy 12p Syndrome. Hum Genet 40: 135-47, 1978
5. Couzin DA, Watt JL, Auchterlonie IA. A complex double translocation involving four chromosomes and five breakpoints in a child with mild mental retardation. J Med Genet 20: 389-92, 1983
6. Bourrouillou G, Rolland M, Colombies P. Secondary 18p2 due to a paternal double translocation. J Genet Hum 31: 243-9, 1983
7. Siadeer I, Nivalon-Chevallier A, Mugneret F, Turc-Carel C. Double translocation 46,XX,t(2;5),t(2;8) with major reproduction problems. J Genet Hum 36: 89-92, 1988.