Combination treatment of 5-FU and TNF-beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-beta on both cell lines.
📌 3 Key Takeaways
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Objective & Hypothesis:Cervical carcinoma is one type of cancer with a high mortality rate in females.
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Key Findings & Data:In this study, we investigated the cytotoxic effects of TNF-beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa.
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Conclusion & Impact:Combination treatment of 5-FU and TNF-beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-beta on both cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Cervical carcinoma is one type of cancer with a high mortality rate in females. In this study, we investigated the cytotoxic effects of TNF-beta, 5-FU and their combinations on human cervical carcinoma cell lines, ME180 and HeLa. The highest degree of cytotoxic effect was obtained with 5-FU on both cell lines. While high concentrations of TNF-beta showed cytotoxic effects on both cell lines, the lowest dose induced growth. Combination treatment of 5-FU and TNF-beta gave a slightly higher cytotoxic and antiproliferative response compared to individual use of 5-FU and TNF-beta on both cell lines.
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Cite This Article
AKÇA, H., ÖZEŞ, O. N. (2022). Antitumor effects of TNF-beta, 5-FU and their combinations on cervical carcinoma cell lines. Turkish Journal of Medical Sciences, Cilt: 32 - Sayı: 2, 127–132. https://ajindex.com/articles/612229
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