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Journals / Turkish Journal of Medical Sciences / 2002 / Cilt: 32 - Sayı: 2

Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma

Murat ÜNAL
İsmail ÇÖLHAN
Mesut Can KARATAY
Ayhan BİLİR
Pages
139–143
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and adjacent tumor-free tissue (mean TLI value = 9.16±3.32%) (p

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC).
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Key Findings & Data:The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically.
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Conclusion & Impact:A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and adjacent tumor-free tissue (mean TLI value = 9.16±3.32%) (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Thymidine labeling index · laryngeal squamous cell carcinoma · prognostic factors

Abstract

The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically. The tissues (tumoral and adjacent tumor-free tissue) that were obtained during surgery were labeled with 3H-Thymidine. TLI was calculated as the number of labeled tumor cells * 100 / total number of tumor cells. A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and adjacent tumor-free tissue (mean TLI value = 9.16±3.32%) (p

Özet

The aim of this study was to investigate the prognostic value of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI in tumor tissue and adjacent healthy tissue was assessed prospectively in 31 patients and these values were correlated with age, TNM, grade and recurrence statistically. The tissues (tumoral and adjacent tumor-free tissue) that were obtained during surgery were labeled with 3H-Thymidine. TLI was calculated as the number of labeled tumor cells * 100 / total number of tumor cells. A statistically significant difference was observed between tumor tissue (mean TLI value = 17.62± 6.39%) and adjacent tumor-free tissue (mean TLI value = 9.16±3.32%) (p

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Cite This Article

ÜNAL, M., ÇÖLHAN, İ., KARATAY, M. C., BİLİR, A. (2022). Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma. Turkish Journal of Medical Sciences, Cilt: 32 - Sayı: 2, 139–143. https://ajindex.com/articles/612208

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