The depth of these changes correlates with the heaviness of the pathological process.
📌 3 Key Takeaways
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Objective & Hypothesis:It has been revealed that in alloxane diabetes the content of the main phospholipids - phosphatidylcholine, phosphatidyletanolamine and phosphatidyl-phosphatidylinosite -decreases in the cells of the vascular wall, whereas the content of the methyl ethers of the fatty acids is not changed, and the content of the fractions of lipids (monoglycerides, diglycerides, triglycerides, cholesterol, free fatty acids, and cholesterol ethers) and phospholipids (phosphatidylserine, cardiolipin, lysophosphatidyletanolamine, lysocardiolipin, sphingomyelin, phosphatide acid and lysophosphatide acid) increase.
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Key Findings & Data:It has been revealed that in alloxane diabetes the content of the main phospholipids - phosphatidylcholine, phosphatidyletanolamine and phosphatidyl-phosphatidylinosite -decreases in the cells of the vascular wall, whereas the content of the methyl ethers of the fatty acids is not changed, and the content of the fractions of lipids (monoglycerides, diglycerides, triglycerides, cholesterol, free fatty acids, and cholesterol ethers) and phospholipids (phosphatidylserine, cardiolipin, lysophosphatidyletanolamine, lysocardiolipin, sphingomyelin, phosphatide acid and lysophosphatide acid) increase.
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Conclusion & Impact:The depth of these changes correlates with the heaviness of the pathological process.
It has been revealed that in alloxane diabetes the content of the main phospholipids - phosphatidylcholine, phosphatidyletanolamine and phosphatidyl-phosphatidylinosite -decreases in the cells of the vascular wall, whereas the content of the methyl ethers of the fatty acids is not changed, and the content of the fractions of lipids (monoglycerides, diglycerides, triglycerides, cholesterol, free fatty acids, and cholesterol ethers) and phospholipids (phosphatidylserine, cardiolipin, lysophosphatidyletanolamine, lysocardiolipin, sphingomyelin, phosphatide acid and lysophosphatide acid) increase. The depth of these changes correlates with the heaviness of the pathological process.
Özet
It has been revealed that in alloxane diabetes the content of the main phospholipids - phosphatidylcholine, phosphatidyletanolamine and phosphatidyl-phosphatidylinosite -decreases in the cells of the vascular wall, whereas the content of the methyl ethers of the fatty acids is not changed, and the content of the fractions of lipids (monoglycerides, diglycerides, triglycerides, cholesterol, free fatty acids, and cholesterol ethers) and phospholipids (phosphatidylserine, cardiolipin, lysophosphatidyletanolamine, lysocardiolipin, sphingomyelin, phosphatide acid and lysophosphatide acid) increase. The depth of these changes correlates with the heaviness of the pathological process.
IRGASHEVA, G. M., KLEMESHEVA, L. S., ALMATOV, K. T. (2022). The Problem of Lipid Exchange in Vessel Walls in Insulin Deficit. Turkish Journal of Medical Sciences, Cilt: 32 - Sayı: 6, 469–473. https://ajindex.com/articles/612205