These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
📌 3 Key Takeaways
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Objective & Hypothesis:Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli.
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Key Findings & Data:Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine.
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Conclusion & Impact:These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Glutathione (GSH) exerts a variety of cytoprotecive effects, but is readily depleted from cells under a variety of stressful stimuli. The impact of GSH depletion on receptor-mediated activity in rat hepatocytes has been studied with regard to glycogenolysis stimulated with a-adrenoceptor agonists or glucagon, which exert their actions through different signalling pathways. Depletion of GSH content (70%) by diethyl maleate had no effect on the redox status of the cells or on basal or glucagon-stimulated glycogenolysis, but significantly reduced the response to the a-adrenoceptor agonists adrenalin and phenylephrine. These results highlight the possible modulatory effects of GSH on receptor-mediated activity in hepatocytes.
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Cite This Article
ATMACA, M., FRY, J. R. (2022). Differential effect of glutathione depletion on glycogenolysis in isolated rat hepatocytes mediated by alpha-adrenoceptor agonists and glucagon. Turkish Journal of Medical Sciences, Cilt: 35 - Sayı: 2, 71–74. https://ajindex.com/articles/612015
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