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Journals / Turkish Journal of Medical Sciences / 2007 / Cilt: 37 - Sayı: 3

Cobalamin Deficiency During Pregnancy Expressed as Elevated Urine Methylmalonic Acid Levels Determined by a Photometric Assay

Osman Metin İPÇİOĞLU
Mustafa GÜLTEPE
Ömer ÖZCAN
Pages
139–143
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: The tHcy concentrations were not elevated (

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia.
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Key Findings & Data:Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls.
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Conclusion & Impact:Results: The tHcy concentrations were not elevated (
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cobalamin deficiency · pregnancy · urine MMA

Abstract

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We aimed to evaluate cobalamin state in pregnancy by using urine MMA levels determined by an economic spectrophotometric method. Materials and Methods: For this cross-sectional study, plasma total homocysteine (tHcy), serum folate and vitamin B12, and urine MMA levels were measured in 186 uncomplicated pregnant women (30 in first, 58 in second and 98 in third trimester). MMA measurements were made in first morning urine samples with normalizing by creatinine concentrations. Results: The tHcy concentrations were not elevated (

Özet

Aim: Deficiency of cobalamin and folate during pregnancy is associated with megaloblastic anemia. Lower levels of folate and vitamin B12 were reported in mothers whose offspring had neural tube defects compared to unaffected controls. Increased methylmalonic acid (MMA) levels are a sensitive indicator of mild vitamin B12 deficiency and elevated homocysteine levels denote vitamin B12 or folate deficiency. We aimed to evaluate cobalamin state in pregnancy by using urine MMA levels determined by an economic spectrophotometric method. Materials and Methods: For this cross-sectional study, plasma total homocysteine (tHcy), serum folate and vitamin B12, and urine MMA levels were measured in 186 uncomplicated pregnant women (30 in first, 58 in second and 98 in third trimester). MMA measurements were made in first morning urine samples with normalizing by creatinine concentrations. Results: The tHcy concentrations were not elevated (

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Cite This Article

İPÇİOĞLU, O. M., GÜLTEPE, M., ÖZCAN, Ö. (2022). Cobalamin Deficiency During Pregnancy Expressed as Elevated Urine Methylmalonic Acid Levels Determined by a Photometric Assay. Turkish Journal of Medical Sciences, Cilt: 37 - Sayı: 3, 139–143. https://ajindex.com/articles/611846

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