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Journals / Turkish Journal of Medical Sciences / 2009 / Cilt: 39 - Sayı: 6

The predictive role of AST level, prothrombin time, and platelet count in the detection of liver fibrosis in patients with chronic hepatitis C

Kronik hepatit C’li hastalarda karaciğer fibrozisinin saptanmasında AST seviyesi, protrombin zamanı, ve trombosit sayısının belirleyici rolü

Bahar TAŞDELEN
Güliz SARAÇOĞLU
Özlem KANDEMİR
Gürbüz POLAT
Pages
857–862
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The relationship between the platelet count

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: We aimed to assess the predictive value of a combination some of basic serum biochemical markers for the diagnosis of clinically significant fibrosis in chronic hepatitis C.
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Key Findings & Data:Materials and methods: Blood samples from 68 patients with chronic hepatitis C infection were analyzed for aspartate aminotransferase, prothrombin INR, and platelet count.
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Conclusion & Impact:The relationship between the platelet count
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kronik hepatit C · fibrozis · serum biyokimyasal belirleyicileri

Abstract

Aim: We aimed to assess the predictive value of a combination some of basic serum biochemical markers for the diagnosis of clinically significant fibrosis in chronic hepatitis C. Materials and methods: Blood samples from 68 patients with chronic hepatitis C infection were analyzed for aspartate aminotransferase, prothrombin INR, and platelet count. The liver histopathology was evaluated using the Knodell protocol. The relationship between the serum biochemical markers and severity of the stages were examined. Results: A strong association was found between the fibrosis stage and platelet count and GUCI (P < 0.001, P = 0.035 respectively) but not APRI ([AST/ULN] / Platelet count [ ×109 /L]) × 100) (P = 0.052). The relationship between the platelet count

Özet

Amaç: Kronik hepatit C’de bazı temel serum biyokimyasal testlerinin şiddetli fibrozisi tanımlamadadoğruluk derecelerini değelendirmeyi amaçladık.Yöntem ve gereç: Kronik hepatit C enfeksiyonlu 68 hastadan kan örnekleri aspartat minotransferaz,protrombin zamanı ve trombosit sayısı için analiz edildi. Karaciğer histopatolojisi Knodell protokolükullanılarak değerlendirildi. Serum biyokimyasal belirleyicileri ve stage şiddeti arasındaki ilişkiaraştırıldı.Bulgular: Fibrozis derecesi ile trombosit sayısı ve GUCI arasındaki ilişki anlamlı bulundu (P < 0,001,P = 0,035, sırayla), ancak APRI ile ([AST/ULN] / Trombosit sayısı [×109 /L]) × 100) (P = 0.052)anlamlı bulunmadı. Trombosit sayısının <147 × 109 /L olması ve yaşın 50’nin üzerinde olması ileciddi fibrozis arasındaki ilişki anlamlı bulundu (AUC = 0.779, P < 0.001). Bu eşik değerde pozitifprediktif değer ve negatif prediktif değer sırayla % 66,7 and % 86,7 olarak belirlendi. GUCI indeksi(Göteborg University Cirrhosis Index) AST, trombosit sayısı ve protrombin zamanı kullanılarakhesaplandı. Eşik değer bu indeks için 0.26 alındığında testin şiddetli fibrozisi saptamada sensitivitesi% 58,33, spesifisitesi % 72,7, negatif prediktif değeri ve pozitif prediktif değeri sırayla % 76,2 and %53,8 bulundu.Sonuç: Periferik trombosit sayısı ve GUCI şiddetli fibrozisli hastaları (stage 3-4), fibrozisi şiddetliolmayanlardan (stage 1-2) belirli bir doğruluk derecesinde ayırt ettirebilir.

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Cite This Article

TAŞDELEN, B., SARAÇOĞLU, G., KANDEMİR, Ö., POLAT, G. (2022). The predictive role of AST level, prothrombin time, and platelet count in the detection of liver fibrosis in patients with chronic hepatitis C. Turkish Journal of Medical Sciences, Cilt: 39 - Sayı: 6, 857–862. https://ajindex.com/articles/611695

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